Synchronous control of magnetic particles and magnetized cells in a tri-axial magnetic field

Abedini-Nassab, Roozbeh; Bahrami, Sajjad

doi:10.1039/d1lc00097g

Cited by 17 publications

(12 citation statements)

References 48 publications

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“…The optimized mechanical mode enables the selective control of the target particles without additional elements, such as the application of z -field, current, and programmed three-dimensional fields, that influence the movement of all non-target particles simultaneously under a magnetic field for the desired control. 39,41,44,48,49 Herein, we demonstrated a four-step basic and two-step additional manipulation combined with the mode from symmetry breaking, as shown in Fig. 6.…”

Section: Resultsmentioning

confidence: 99%

“…Because 2D thin-film structures do not affect topography formation, and driving forces around the local landscape are independent to each target. Therefore, the magnetophoretic circuit concept [36][37][38][39][40][41][42][43][44][45] using thin-film patterns is most suitable for investigating topographic effects among magnetic field-based technologies. The magnetophoretic circuit allows the particles to continuously move according to the magnetic energy distribution of the micro-magnets without additional fluid flow.…”

Section: Materials Horizonsmentioning

confidence: 99%

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Tailoring matter orbitals mediated using a nanoscale topographic interface for versatile colloidal current devices

et al. 2022

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Section: Resultsmentioning

confidence: 99%

Section: Materials Horizonsmentioning

confidence: 99%

Tailoring matter orbitals mediated using a nanoscale topographic interface for versatile colloidal current devices

et al. 2022

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“…Magnetic particles move to the low-energy region under the effect of the magnetic field gradient. When the energy distribution is examined, the trajectory of the particle can be predicted and controlled by manipulation of external magnetic energy [ 133 , 134 ]. The Joule heating-induced temperature gradient drives a controllable electric current to manipulate micron-sized particles [ 11 ].…”

Section: Microfluidicsmentioning

confidence: 99%

Biomedical Applications of Microfluidic Devices: A Review

et al. 2022

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Both passive and active microfluidic chips are used in many biomedical and chemical applications to support fluid mixing, particle manipulations, and signal detection. Passive microfluidic devices are geometry-dependent, and their uses are rather limited. Active microfluidic devices include sensors or detectors that transduce chemical, biological, and physical changes into electrical or optical signals. Also, they are transduction devices that detect biological and chemical changes in biomedical applications, and they are highly versatile microfluidic tools for disease diagnosis and organ modeling. This review provides a comprehensive overview of the significant advances that have been made in the development of microfluidics devices. We will discuss the function of microfluidic devices as micromixers or as sorters of cells and substances (e.g., microfiltration, flow or displacement, and trapping). Microfluidic devices are fabricated using a range of techniques, including molding, etching, three-dimensional printing, and nanofabrication. Their broad utility lies in the detection of diagnostic biomarkers and organ-on-chip approaches that permit disease modeling in cancer, as well as uses in neurological, cardiovascular, hepatic, and pulmonary diseases. Biosensor applications allow for point-of-care testing, using assays based on enzymes, nanozymes, antibodies, or nucleic acids (DNA or RNA). An anticipated development in the field includes the optimization of techniques for the fabrication of microfluidic devices using biocompatible materials. These developments will increase biomedical versatility, reduce diagnostic costs, and accelerate diagnosis time of microfluidics technology.

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“…Furthermore, to prevent particle-particle attractive force in an in-plane field, we have demonstrated magnetophoretic circuits operating in a three-dimensional external magnetic field [ 113 , 114 , 115 ]. The vertical magnetic field bias in this platform results in particle-particle repulsion force and prevents particle cluster formation, which may be seen in two-dimensional fields.…”

Section: Particle Manipulationmentioning

confidence: 99%

“…( i ) The experimental trajectory of a magnetic particle transported along the magnetic track is shown with the black line. Reprinted from R. Abedini-Nassab, et al, 2021 Lab on a Chip 21, 1998–2007 [ 115 ] with permission from Royal Society of Chemistry.…”

Section: Figurementioning

confidence: 99%

Microfluidic Synthesis, Control, and Sensing of Magnetic Nanoparticles: A Review

2021

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Magnetic nanoparticles have attracted significant attention in various disciplines, including engineering and medicine. Microfluidic chips and lab-on-a-chip devices, with precise control over small volumes of fluids and tiny particles, are appropriate tools for the synthesis, manipulation, and evaluation of nanoparticles. Moreover, the controllability and automation offered by the microfluidic chips in combination with the unique capabilities of the magnetic nanoparticles and their ability to be remotely controlled and detected, have recently provided tremendous advances in biotechnology. In particular, microfluidic chips with magnetic nanoparticles serve as sensitive, high throughput, and portable devices for contactless detecting and manipulating DNAs, RNAs, living cells, and viruses. In this work, we review recent fundamental advances in the field with a focus on biomedical applications. First, we study novel microfluidic-based methods in synthesizing magnetic nanoparticles as well as microparticles encapsulating them. We review both continues-flow and droplet-based microreactors, including the ones based on the cross-flow, co-flow, and flow-focusing methods. Then, we investigate the microfluidic-based methods for manipulating tiny magnetic particles. These manipulation techniques include the ones based on external magnets, embedded micro-coils, and magnetic thin films. Finally, we review techniques invented for the detection and magnetic measurement of magnetic nanoparticles and magnetically labeled bioparticles. We include the advances in anisotropic magnetoresistive, giant magnetoresistive, tunneling magnetoresistive, and magnetorelaxometry sensors. Overall, this review covers a wide range of the field uniquely and provides essential information for designing “lab-on-a-chip” systems for synthesizing magnetic nanoparticles, labeling bioparticles with them, and sorting and detecting them on a single chip.

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Synchronous control of magnetic particles and magnetized cells in a tri-axial magnetic field

Abstract: Precise manipulation of single particles is one of the main goals in the lab-on-a-chip field. Here, we present a microfluidic platform with “T” and “I” shaped magnetic tracks on the...

Cited by 17 publications

References 48 publications

Tailoring matter orbitals mediated using a nanoscale topographic interface for versatile colloidal current devices

Tailoring matter orbitals mediated using a nanoscale topographic interface for versatile colloidal current devices

Biomedical Applications of Microfluidic Devices: A Review

Microfluidic Synthesis, Control, and Sensing of Magnetic Nanoparticles: A Review

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