Synchronous gastric and ampullary adenocarcinomas in a hairy cell leukemia patient treated with pentostatin eight years prior

Abstract

Hairy cell leukemia patients are at increased risk for second malignancies, including both solid and lymphoid neoplasms. Along with other factors, multiple immune defects present in hairy cell leukemia likely contribute to subsequent carcinogenesis. We report herein a case of synchronous high-grade gastric and ampullary adenocarcinomas in a patient with a history of hairy cell leukemia treated eight years prior with pentostatin. We include a review of immune alterations induced by both hairy cell leukemia and its therapies, and link them with the occurrence of second cancers in these patients.

Višestruki zloćudni tumori u pacijenta s leukemijom vlasastih stanica: prikaz slučaja

“…Karakteristična je ekspresija koreceptora CD25, CD103, CD11c i CD123 na površini limfocita 2 . HCL se povezuje s pojavom višestrukih zloćudnih tumora, što uključuje solidne tumore i neoplazme podrijetla limfocita 4,5 . Postoje mnoge epidemiološke studije, provedene na raznim geografskim lokacijama, koje ukazuju na povećanu incidenciju sekundarnih tumora u pacijenata s HCL-om, a prva takva studija provedena je u SAD-u 1985. godine 5 .…”