Synchronous Gastric Gastrointestinal Stromal Tumor and Signet-Ring Cell Adenocarcinoma: A Case Report

Abstract

Synchronous tumors of the stomach are uncommon. We present a unique case of gastric synchronous tumors composed of signet-ring cell adenocarcinoma and gastrointestinal stromal tumor (GIST). The two tumors arose at the same site and were sharply juxtaposed without intermingling of morphologically distinct elements. Coincidence probably accounts for this occurrence, even if a common carcinogenic agent had been hypothesized. Preoperative imaging and endoscopic biopsy could lead to the suspicion of synchronous tumors, and an accurate histological identification of both tumors could be achieved by multiple deep endoscopic biopsies. The presence in our case of diffuse carcinomatosis indicates that the signet-ring cell adenocarcinoma had a greater adverse effect on the prognosis than the GIST.

Simultaneous adenocarcinoma and leiomyoma of the stomach presenting as a collision tumor

“…Lee et al [18] reported a similar case of large GIST in which simultaneous signet ring cell carcinoma was detected by pathological examination prior to surgery. In their case, since curative resection could not be achieved because of the advanced stage of the gastric cancer including multiple peritoneal seeding, the histopathological diagnosis prior to surgery did not have an impact on their treatment strategy.…”

“…Simultaneous occurrence of adenocarcinoma and SMT has occasionally been observed and reported [13][14][15][16][17][18][19] but they usually originate at different sites within the stomach [13][14][15]17]. Although accurate incidence of collision tumors of adenocarcinoma and SMT is not yet determined, it is considered to be extremely rare and is usually reported as case reports.…”

“…Although accurate incidence of collision tumors of adenocarcinoma and SMT is not yet determined, it is considered to be extremely rare and is usually reported as case reports. Lee et al [18] and Trabelsi et al [19] reported a collision tumor of signet ring cell carcinoma and CD 117 positive GIST. On the other hand, Liu et al [16] reported a collision tumor of intestinal type adenocarcinoma and CD117 positive GIST.…”

Midenin Senkron Gastrointestinal Stromal Tümör ve Primer Adenokarsinomu

“…We anticipate that the stomach may have been influenced by the same unknown carcinogen, resulting in simultaneous proliferation of different cell lines (epithelial and stromal cells) especially in the elderly. A potential pluripotent stem cell could also be the initial target of the carcinogen or causal influence, however, further studies are needed to clarify these possibilities (14). Maiorana et al suggested that gene mutations might underlie tumour predisposition in patients harbouring a double gastric neoplasia (11).…”

Coexistence of multiple gastrointestinal stromal tumors and signet ring cell carcinoma of stomach in a patient with neurofibromatosis type-1: case report

“…Günümüze kadar GiST'lerin mide, kolon, rektum adenokarsinomlari, mide taçli yüzük hücreli karsinomu, özefagus karsinomu, safra kesesi karsinomu, pankreas karsinomu, hepatosellüler karsinom, même karsinomu, renal hücreli karsinom, prostat adenokarsinomu, endometrium adenokarsinomu, over karsinomu, akciger karsinomu, tiroid karsinomu, lenfoma, lösemi, nöroendokrin tümör, melanom ve adrenal nöroblastoma gibi farkli tümörlerle birlikteligi saptanmiçtir (13)(14)(15)(16). Ek olarak 2010 yilinda Soyuer ve ark.…”