Synchronous multiple thymoma: Report of three cases

Suzuki, Hidemi; Yoshida, Shigetoshi; Hiroshima, Kenzou; Nakatani, Yukio; Yoshino, Ichiro

doi:10.1007/s00595-009-4080-z

Cited by 20 publications

(16 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies have reported that multiple lesions of thymoma were known in 1.0 to 3.1% of all patients undergoing resection [1,2]. There were no cases of multifocal thymoma in our patients.…”

Section: Discussionsupporting

confidence: 47%

“…Complete resection of the thymus gland has been widely supported as part of thymoma resection because intrathymic metastasis or multifocal recurrence of thymoma can lead to local recurrence [1,2]. For the same reason, the International Thymic Malignancy Interest Group (ITMIG) suggests a complete thymectomy for patients without myasthenia gravis (MG) and extended thymectomy for patients with MG [3].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Recurrence after thymoma resection according to the extent of the resection

Bae

Lee

Kim

et al. 2014

J Cardiothorac Surg

View full text Add to dashboard Cite

BackgroundComplete resection of the thymus is considered appropriate for a thymoma resection because any remaining thymic tissue can lead to local recurrence. However, there are few studies concerning the extent of thymus resection. Therefore, we conducted a retrospective study to investigate whether recurrence following thymoma resection correlated to the extent of resection.MethodsBetween 1986 and 2011, a total of 491 patients underwent resection of thymic epithelial tumors with curative intent. Of those, we excluded patients with an undetermined World Health Organization (WHO) histologic type, patients with type C thymoma, and patients who underwent incomplete resection (n = 21). The remaining 342 patients were reviewed retrospectively and compared recurrence according to the extent of resection.ResultsExtended thymectomy was performed in 239 patients (69.9%) and limited thymectomy was performed 103 patients (30.1%). In the extended thymectomy group, 29 recurrences occurred, and in the limited thymectomy group, 10 recurrences occurred.Comparing rates of freedom from recurrence between two groups, there was no significant statistical difference in total recurrence (p =0.472) or local recurrence (p =0.798). After matching patients by stage and tumor size, there was no significant difference in freedom from recurrence between the two groups (p = 0.162). Additionally, after adjusting for histologic type and MG, there was also no significant difference (p = 0.125) between groups.ConclusionsNo difference in the rate of recurrence was observed in patients following limited thymectomy compared with extended thymectomy.

show abstract

Section: Discussionsupporting

confidence: 47%

Section: Introductionmentioning

confidence: 99%

Recurrence after thymoma resection according to the extent of the resection

Bae

Lee

Kim

et al. 2014

J Cardiothorac Surg

View full text Add to dashboard Cite

show abstract

“…Although thymoma is the most common tumor of the anterior mediastinum, multiple developments are uncommon [3][4][5][6]. Moreover, metachronous onset, which occurred over 3 years in the present case, is extremely rare; most reported cases have involved synchronous onset.…”

Section: Discussionmentioning

confidence: 57%

“…There are two hypotheses as to the origin of multiple thymoma: deriving from multicentric development or intra-thymic metastasis. In the case of different histological subtypes, the multicentric hypothesis seems more suitable [3,7]. Intra-thymic metastasis, however, cannot be excluded if the tumors have the same characteristics [8].…”

Section: Discussionmentioning

confidence: 99%

Metachronous multiple thymoma with different clinical behavior and pathological findings

et al. 2016

View full text Add to dashboard Cite

A 70-year-old woman presented with a nodule in the left hilum on a chest radiograph 3 years before. Another mass emerged caudal to the initial nodule and was diagnosed as thymoma. A surgical specimen revealed two components: an encapsulated rostral nodule and a caudal mass invading the left lung. Histological findings showed that the rostral nodule was a stage 1 type B2 thymoma, whereas the caudal mass was a stage 3 type B3 thymoma. Based on the differences in biological behavior and histological findings, we concluded that these tumors derived from multicentric origin.

show abstract

“…However, there are some critical points: first of all, the possibility of a potentially incomplete resection in case of limited thymectomy is higher, particularly at stage II, as shown in a study from the Chinese Alliance for Research in Thymoma (2.9% vs. 14.5%) (14). Furthermore, it has been well described that also at early stages thymoma could present multiple nodules in the remaining gland (15) or show different histologies (also more aggressive) in a single nodule (16) that could negatively affect prognosis due to an increased recurrence rate. In addition, follow-up of these patients must obviously be longer and, once again, we need prospective studies.…”

mentioning

confidence: 99%