Synchronous primary adenocarcinoma, mucosa‐associated lymphoid tissue lymphoma and a stromal tumor in a <i>Helicobacter pylori</i>‐infected stomach

Kaffes, Arthur J.; Hughes, Lorna; Hollinshead, John; Katelaris, Peter

doi:10.1046/j.1440-1746.2002.02649.x

Cited by 59 publications

(43 citation statements)

References 11 publications

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“…Kaffles et al 1 apresentam um doente em que foram diagnosticados, sincronicamente, adenocarcinoma, tumor estromal e linfoma.…”

Section: Discussionunclassified

“…A ocorrência de tumores primários múltiplos no estômago não é rara, a incidência varia entre 2 a 3%, sendo a maioria dos casos composta por adenocarcinomas múltiplos ou associação entre adenocarcinoma e linfoma (MALT) 1 . Entretanto, adenocarcinoma e tumor mesenquimal (GIST) sincrônicos é muito raro, com apenas alguns relatos de casos na literatura 2 .…”

Section: Introductionunclassified

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Adenocarcinoma e tumor estromal (GIST) sincrônicos no estômago: uma rara ocorrência

Camargo

Andreollo

Hatsumura

et al. 2008

Rev. Col. Bras. Cir.

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“…Kaffles et al 1 apresentam um doente em que foram diagnosticados, sincronicamente, adenocarcinoma, tumor estromal e linfoma.…”

Section: Discussionunclassified

Section: Introductionunclassified

Adenocarcinoma e tumor estromal (GIST) sincrônicos no estômago: uma rara ocorrência

Camargo

Andreollo

Hatsumura

et al. 2008

Rev. Col. Bras. Cir.

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“…In one study, significantly more synchronous or metachronous gastrointestinal neoplasms were found in GIST patients compared to malignancies occur ring in the nor mal Hung arian population [11] . Furthermore, cases of synchronously occurring GIST and mucosa associated lymphoid tissue as well as GIST and carcinoid tumors of the stomach have been described in the literature [12,13] . Janovisk et al [14] recently reported a case of coexistence of hepatocellular carcinoma and GIST.…”

Section: Discussionmentioning

confidence: 99%

Development of multiple myeloma in a patient with gastrointestinal stromal tumor treated with imatinib mesylate: A case report

Tzilves

Gatopoulou²,

Zervas³

et al. 2007

WJG

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.In some rare cases coexistence of GIST with other malignancies has been reported [2][3][4][5][6] . Here we describe a case of a 74-year old male with GIST who developed multiple myeloma (MM) during the course of GIST treatment. To the best of our knowledge, the co-existence of GIST and multiple myeloma has not been reported so far. Case reportA 74-year old male was presented complaining of dyspepsia. Clinical examination revealed a palpable epigastric mass, with no other abnormal clinical findings. Computed tomography of the abdomen showed a 15 cm × 16 cm solid mass in the right side of abdomen, deriving from the gastric wall. A submucosal non-metastatic tumor was suspected ( Figure 1A). Endoscopy showed normal mucosa of the gastrointestinal tract. Laboratory tests were normal. During the surgery, a 5 cm × 11 cm mass of the posterior wall of the gastric antrum protruding from the inner muscularis propria to the mucosa was found. The mass was completely resected and the histological examination demonstrated whirling sheets of spindle cells which were stained positively for CD 117 (c-kit) and CD34, mitotic index > 10/50 HPF, while smooth muscle actin (SMA) and vimentin were focally positive, and keratine, desmin, S-100 protein were negative. This specific immunophenotype characterized GIST. No further therapy was applied. Physical examination, laboratory tests and computed tomography were performed when the patient was followed up at 3-month intervals.Fourteen months after resection, a CT scan of the abdomen showed liver metastases ( Figure 1B) and imatinib mesylate at a dose of 400 mg once daily, as the appropriate second line therapy, was administered. After one month of treatment, the patient reported persistent skeletal pain, especially on the thorax, accompanied with weakness and fatigue. X-ray bone survey showed lytic lesions. Laboratory examination revealed normocytic, normochromic anemia (Hb: 10.6 gr/dL), hypercalciemia (Ca: 11.7 mg/dL) and abnormal ESR (140 mm/h). Serum protein electrophoresis and immunofixation showed an AbstractGastrointestinal stromal tumors (GISTs) are rare tumors, which represent approximately 1% of the neoplasms of the gastrointestinal tract. These tumors rarely give extra-abdominal metastases. However, their clinical outcome is potentially adverse. In some rare cases, coexistance of GISTs with other malignancies has been reported. Here we present a case of a 74-year old male with GIST, which was managed by surgical resection. Fourteen months later, the patient presented with liver metastases and imatinib mesylated was administered. During treatment, the patient reported skeletal pain and plane X-rays revealed osteolytic bone lesions. Further investigation revealed the presence of multiple myeloma. To the best of our knowledge, this is the first report of the co-existence of multiple myeloma (MM) with GIST.

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“…denaturing high-performance liquid chromatography (DHPLC) as described elsewhere (18). For each abnormal elution profile, genomic DNA was directly sequenced in both directions using a CEQ Dye-Terminator Cycle Sequencing kit (Beckman Coulter Inc., Miami, FL, USA) according to the manufacturer's protocol.…”

Section: Methodsmentioning

confidence: 99%

“…The association of gastric GIST and adenocarcinoma or mucosa-associated lymphoid tissue (MALT) lymphoma may be due to environmental or iatrogenic factors including Helicobacter pylori infection (18), dietary carcinogenesis and some drugs (19) that interact with the epithelial and stromal tissues in the stomach inducing the development of different neoplasms, and in addition, may be favored by a high incidence of tumors among the given population (20). Furthermore, it is possible that such an association may be caused by a single genetic aberration predisposing to the development of various histologic types of gastric neoplasms.…”

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confidence: 99%

Gastrointestinal stromal tumor and other primary metachronous or synchronous neoplasms as a suspicion criterion for syndromic setting

et al. 2009

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Abstract.Gastrointestinal stromal tumors (GISTs) may be sporadic or inherited. Although KIT and PDGFRA activating mutations are the oncogenic mechanisms in most sporadic and inherited GISTs, a small subset of GISTs are negative for both. Besides the classical Familial GIST Syndrome, GIST can occur as part of multi-neoplastic disease. The present study was designed to analyze the synchronous and metachronous tumors developed among GIST patients assessed by our institution for GIST Syndrome setting recognition. Patients (n=141) with primary GIST (77 men and 64 women) were recruited between 1988 and 2007 and their clinical and pathological records were reviewed. Mutation analysis of KIT, PDGFRA, NF1 and MMR genes was performed on somatic and peripheral blood DNA. GISTs occurred associated with other primary malignancies in 46 of 141 (32.6%) patients. The most common neoplasms were gastrointestinal and genitourinary. A novel exon 6 germline large deletion of NF1 was identified in the NF1/ GIST kindred. The development of GIST associated with other neoplasms is common and diagnosis of peculiar benign associated-neoplasms warrants the search for familial cancer susceptibility. In particular, syndromic or familial settings have to be suspected in the presence of neurofibroma or lung chordoma in C-KIT and PDGFRA negative GIST patients.

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Synchronous primary adenocarcinoma, mucosa‐associated lymphoid tissue lymphoma and a stromal tumor in a Helicobacter pylori‐infected stomach

Cited by 59 publications

References 11 publications

Adenocarcinoma e tumor estromal (GIST) sincrônicos no estômago: uma rara ocorrência

Adenocarcinoma e tumor estromal (GIST) sincrônicos no estômago: uma rara ocorrência

Development of multiple myeloma in a patient with gastrointestinal stromal tumor treated with imatinib mesylate: A case report

Gastrointestinal stromal tumor and other primary metachronous or synchronous neoplasms as a suspicion criterion for syndromic setting

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