Synchronous renal cell carcinoma and clear cell hepatocellular carcinoma mimicking metastatic disease

Hou, Tai-Cheng; Wu, Chen-Chung; Yang, Chi-Re; Wang, John

doi:10.1016/j.prp.2009.06.008

Cited by 10 publications

(4 citation statements)

References 4 publications

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“…In addition, microscopically, CCC of liver was similar to clear cell tumors from other sites including adrenal gland, kidney, ovary, lung, and pancreas (17,18), making it difficult to differentiate it from the metastatic CCC of the liver. Murakata et al (19) reported that the hepatocyte antibody (DAKO) IHC staining distinguished primary CCC of liver from other clear cell malignancies with a sensitivity of 90% and specificity of 100%.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological features and surgical outcomes of four rare subtypes of primary liver carcinoma

et al. 2018

Chinese Journal of Cancer Research

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Section: Discussionmentioning

confidence: 99%

Clinicopathological features and surgical outcomes of four rare subtypes of primary liver carcinoma

et al. 2018

Chinese Journal of Cancer Research

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“…CCHCC histologically resembles clear cell tumors from other sites including adrenal gland, kidney, ovary, lung, and pancreas . Rare variants of breast carcinoma may also show clear cell morphology, and should be included in the differential diagnosis, particularly when the patient has a history of breast cancer.…”

Section: Discussionmentioning

confidence: 99%

Clear cell hepatocellular carcinoma diagnosed by bile duct brushing cytology

Mitchell

Cai

2015

Diagnostic Cytopathology

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Clear cell hepatocellular carcinoma (CCHCC) is an uncommon morphologic variant of HCC and rarely invades into the main bile ducts. Here we describe a case of CCHCC that was diagnosed by bile duct brushing cytology. Liquid-based preparation of brushing specimen showed clusters of atypical epithelial cells with abundant clear cytoplasm, round nuclei, and occasional intranuclear inclusions. The tumor cells were positive for HepPar-1 and arginase 1, suggestive of their hepatic origin. The overall morphologic and immunophenotypic features were consistent with CCHCC. The cytological diagnosis was confirmed by histopathologic examination of the resected tumor.

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“…Most common scenario would be a metastatic clear cell renal cell carcinoma or a clear cell carcinoma from the ovaries mimicking clear cell HCC. While a panel of IHC will aid in establishing the diagnosis of a primary vs a metastatic process in the vast majority of cases[64-66], some ovarian clear cell carcinomas may stain with HepPar-1, posing a diagnostic pitfall[65].…”

Section: Selected Subtypes Of Hepatocellular Carcinomamentioning

confidence: 99%

Update on hepatocellular carcinoma: Pathologists’ review

Jabbour

Lagana

Lee

2019

WJG

121

102

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Histopathologic diversity and several distinct histologic subtypes of hepatocellular carcinoma (HCC) are well-recognized. Recent advances in molecular pathology and growing knowledge about the biology associated with distinct histologic features and immuno-profile in HCC allowed pathologists to update classifications. Improving sub-classification will allow for more clinically relevant diagnoses and may allow for stratification into biologically meaningful subgroups. Therefore, immuno-histochemical and molecular testing are not only diagnostically useful, but also are being incorporated as crucial components in predicting prognosis of the patients with HCC. Possibilities of targeted therapy are being explored in HCC, and it will be important for pathologists to provide any data that may be valuable from a theranostic perspective. Herein, we review and provide updates regarding the pathologic sub-classification of HCC. Pathologic diagnostic approach and the role of biomarkers as prognosticators are reviewed. Further, the histopathology of four particular subtypes of HCC: Steatohepatitic, clear cell, fibrolamellar and scirrhous - and their clinical relevance, and the recent consensus on combined HCC-cholangiocarcinoma is summarized. Finally, emerging novel biomarkers and new approaches to HCC stratification are reviewed.

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Synchronous renal cell carcinoma and clear cell hepatocellular carcinoma mimicking metastatic disease

Cited by 10 publications

References 4 publications

Clinicopathological features and surgical outcomes of four rare subtypes of primary liver carcinoma

Clinicopathological features and surgical outcomes of four rare subtypes of primary liver carcinoma

Clear cell hepatocellular carcinoma diagnosed by bile duct brushing cytology

Update on hepatocellular carcinoma: Pathologists’ review

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