Synchronous Spectrofluorimetry Coupled with Third-Order Derivative Signal Processing for the Simultaneous Quantitation of Telmisartan and Chlorthalidone Drug Combination in Human Plasma

Elsonbaty, Ahmed; Hasan, M. A.; Eissa, Maya S.; Hаssаn, Wаfаа S.; Abdulwahab, Sara

doi:10.1007/s10895-020-02639-3

Cited by 19 publications

(9 citation statements)

References 23 publications

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“…The second tool was the interval plot test [ 34 ]. Plots display confidence interval as vertical lines, with the center point corresponding to the interval mean.…”

Section: Resultsmentioning

confidence: 99%

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Simultaneous analysis of two drugs used as supportive treatment for COVID-19: comparative statistical studies and analytical ecological appraisal

et al. 2022

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Pharmaceutical quality control products (QC) demand quick, sensitive, and cost-effective methods to ensure high production at a low cost. Green analytical methods are also becoming more common in pharmaceutical research to cut down on the amount of waste that goes into the environment. Meclizine hydrochloride (MZH) and pyridoxine hydrochloride (PYH) are reported to be excellent for calming down COVID-19. As a result, the amount of MZH and PYH manufactured by multinational pharmaceutical organizations has increased considerably during the last several months. The present work proposes three environmentally friendly, straightforward, and sensitive spectrophotometric procedures for quantification of MZH in the presence of PYH in a pure and marketable formulations. The approaches under examination include ratio subtraction (RSM), induced dual wavelength (IDW), and Fourier self-deconvolution (FSD). PYH, on the other hand, was directly quantified at 290 nm. For both drugs, the procedures follow Beer’s law in the range of (5–50 µg/mL). The RSM, IDW, and FSD methods, as well as the zero-order approach for PYH, have all been verified in accordance with ICH standards. The ecological value of established methodologies was determined using four distinct ways: the national environmental methods index (NEMI), the analytical Eco-scale, the Analytical Greenness Metric (AGREE), and the green analytical process index (GAPI). Comparing the findings to those of the previously described spectrophotometric technique, no major changes were identified.

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“…The second tool was the interval plot test [ 34 ]. Plots display confidence interval as vertical lines, with the center point corresponding to the interval mean.…”

Section: Resultsmentioning

confidence: 99%

“…The Boxplot is yet another important data visualization tool [ 34 ], which depicts the distribution of data between groups, Fig. 8 shows the proposed and reported approaches boxplots in different pharmaceutical formulations.…”

Section: Resultsmentioning

confidence: 99%

Simultaneous analysis of two drugs used as supportive treatment for COVID-19: comparative statistical studies and analytical ecological appraisal

et al. 2022

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“…The analysis parameters are confirmed according to ICH recommendations, and high sensitivity is achieved. The limits of detection (LOD) of CLT and TEL are 4.69 and 1.58 µg/mL, respectively [26].…”

Section: Spectrofluorometric Methodsmentioning

confidence: 99%

Review of Determination of Chlortalidone Levels in Pharmaceutical Preparations and Biological Matrix

Fitrizal¹,

Misfadhila²,

Rivai³

2021

IJPSM

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Chlortalidone is a compound that is often used in the pharmaceutical world as an oral drug to treat hypertension. This review article discusses the summary of methods for determining the concentration of chlorthalidone in pharmaceutical preparations and biological matrices. We took the data collected in this review article was taken through trusted sites such as Google Scholar with the search keywords "chlorthalidone determination," "pharmaceutical preparations," and "biological matrices," with a period of the last twenty years (2001-2021). This review article aims to provide an overview of the assay used to determine the concentration of chlorthalidone either in the form of a single substance or pharmaceutical dosage forms. Overall, the determination of chlorthalidone levels has been carried out using various analytical methods. Including spectrophotometry, high-performance liquid chromatography (HPLC), chemometrics and thin-layer chromatography (TLC) - densitometric, capillary zone electrophoresis (CZE) methods, spectrofluorimetric methods, liquid chromatography-mass spectrometry-mass spectrometry (LC-MS-MS) methods, ultrafast liquid chromatography (UFLC), supercritical fluid chromatography method and high-performance thin-layer chromatography (HPTLC)-densitometric method. Analysis with the HPLC technique is widely used in research because it can detect samples with the lowest concentrations up to the nanogram level.

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“…Thus, most research activities in pharmaceutical analysis aim to achieve the accepted quality levels in both drug and food products. This goal would not have been possible without achieving the interdisciplinary in pharmaceutical analysis research with mathematics, biostatistics, chemometrics, and physical and computational chemistry (Elsonbaty, Hasan, et al, 2021). One example of the achieved interdisciplinary in the pharmaceutical analysis is shown in the previously reported papers, describing the design and optimization of selective electrochemical sensors for drug(s) quantification relying on computational chemistry approaches.…”

Section: Introductionmentioning

confidence: 99%

Current advances in computer-aided design of electrochemical sensors: An analytical review

Elsonbaty

Attala

Eissa

et al. 2023

Records of Pharmaceutical and Biomedical Sciences

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Electrochemical sensors are situated as effective tools for the sensitive and selective determination of several heavy metal traces, pesticides, and a vast diversity of pharmaceuticals in different matrices. The development of advanced electrochemical sensors requires the collaboration of all scientific knowledge especially; computational chemistry, mathematics, and classical and quantum physics. This interdisciplinary in analytical chemistry made it possible to get benefits from molecular modeling, and simulations to develop more selective and sensitive electro-analytical platforms with lowered cost, time, and effort. Recently, the optimization of sensor design was more practical and robust in the light of computational simulation techniques such as molecular docking, dynamics simulation, and quantum calculations. Molecular modeling approaches (MMA) enabled the analyst to explore unrelenting molecular systems ranging from small chemical systems to massive biological molecules and material assemblies in the fields of computational chemistry. Furthermore, MAA has been recently used in the optimization of the design of different electrochemical sensors. Thus, in this review, we went over the different ap-plications of MMA and demonstrate these techniques on both the molecular and quantum levels. Moreover, we focused on the benefits of bringing such innovative techniques to the field of electro-analytical chemistry and highlighted some of the recently reported electrochemical sensors.

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Synchronous Spectrofluorimetry Coupled with Third-Order Derivative Signal Processing for the Simultaneous Quantitation of Telmisartan and Chlorthalidone Drug Combination in Human Plasma

Cited by 19 publications

References 23 publications

Simultaneous analysis of two drugs used as supportive treatment for COVID-19: comparative statistical studies and analytical ecological appraisal

Simultaneous analysis of two drugs used as supportive treatment for COVID-19: comparative statistical studies and analytical ecological appraisal

Review of Determination of Chlortalidone Levels in Pharmaceutical Preparations and Biological Matrix

Current advances in computer-aided design of electrochemical sensors: An analytical review

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