Synchronous tumors arising in a single major salivary gland

Abstract

Multiple separate tumors arising in the major salivary glands are distinctly unusual. The records on 25 patients with synchronous unilateral salivary gland tumors on file at St Louis University and at the Armed literature. Bilateral tumors arose more frequently than multiple unilateral ones. The most common tumors with bilateral synchronous or metachronous development are the Warthin tumors, with more than 100 reported cases; the mixed tumor with at least 34 cases; and the acinic cell carcinoma, with 12 reported cases. The Warthin tumor also was the most likely to present with multifocal unilateral involvement with 29 tumors having three or more separate foci of tumor. The next most common tumor combinations are a Warthin tumor and a mixed tumor (20 cases), the multifocal membranous basal cell adenoma (12 cases), and multiple oncocytomas (nine cases). Numerous other tumor combinations were found covering the range of salivary gland neoplasia, however one of the tumors usually was a mixed tumor or a Warthin tumor.

Sinonasal acinic cell carcinoma: A clinicopathologic study of four cases

“…Acinic cell carcinomas are most common in the fifth and sixth decades of life but are seen in patients of all ages, including children,13–16 in whom acinic cell carcinomas are the second most common salivary gland tumor after mucoepidermoid carcinoma 17. Acinic cell carcinomas are second only to Warthin's tumor in their incidence of bilateral involvement and multifocal nature 18. In the sinonasal tract, the ages in reported cases range from 42 to 76 years (median, 59 years).…”

Salivary Gland Double Tumor: Synchronous Ipsilateral Pleomorphic Adenoma and Acinic Cell Carcinoma of the Parotid Gland

“…A 68-yearold patient described by George et al 14 presented with a terminal duct carcinoma 8 years after excision of a pleomorphic adenoma of the ipsilateral parotid gland. In the experience of Gnepp et al, 15 the most commonly seen combination is a Warthin's tumor and carcinoma, while pleomorphic adenomas are infrequently associated with cancers.…”

Combined salivary duct carcinoma and squamous cell carcinoma suspected of carcinoma ex pleomorphic adenoma

“…Gnepp et al reported that cases with multiple tumor components account for less than 0.3 % of all salivary gland neoplasms, and almost all of these tumors were benign. 4 Here, we report an extremely rare case of Ca ex PA in a parotid gland that consisted of two carcinoma components.…”