Sinonasal acinic cell carcinoma: A clinicopathologic study of four cases

Abstract

Sinonasal acinic cell carcinoma is a distinct low-grade carcinoma that can be distinguished from other neoplasms by light microscopy and histochemical staining methods. Pathologists and surgeons should be aware of the occurrence of this type of salivary gland neoplasm in the sinonasal tract.

Nasal Acinic Cell Carcinoma in a Cat

“…6 Although an individual tumor usually has a predominance of one pattern or cell type, many tumors represent a mixture of these features. 13 In the present case, a mixed pattern was present with lobular, solid, and follicular growth and predominance of an acinic cell type. The diagnosis of acinic cell carcinoma is supported by routine histochemistry demonstrating the characteristic PAS-positive and diastase-resistant cytoplasmic granules.…”

“…5 Cytoplasmic basophilia is a characteristic of this neoplasm, and the PAS-positive cytoplasmic granules are typically resistant to diastase digestion, which makes differentiation from other epithelial neoplasms relatively easy. 13 These tumors arise from the major salivary glands (parotid and submandibular salivary glands) or minor salivary glands that are located throughout the upper aerodigestive tract. In human medicine, acinic cell carcinomas are rare, accounting for approximately 1% of salivary gland tumors.…”

“…In human medicine, acinic cell carcinomas are rare, accounting for approximately 1% of salivary gland tumors. 13 These tumors occur most frequently in the parotid gland and less often in the submandibular and minor intraoral salivary glands. 6 The occurrence in the sinonasal cavities is extremely rare.…”

Carcinome à cellules acineuses du septum nasal

“…ß 2009 Publié par Elsevier Masson SAS. nasales [1], il se développe le plus souvent à partir du cornet inférieur [2]. Le protocole thérapeutique, dans cette localisation, n'est pas standardisé.…”

Acinic Cell Carcinoma of Nasal Cavity: A Rare Site for Salivary Gland Tumour

“…(1) Extensive search of English language medical literature showed only about 18 cases of acinic cell carcinoma previously described in sinonasal location. (2)(3)(4) DOG1/Anoctamin 1, a marker of gastrointestinal stromal tumour, a calcium activated chloride channel protein is also expressed in acinic cells of salivary gland and is useful for delineating acinic cell differentiation in these tumours. (5) We hereby report the clinicopathological features and the role of DOG1 immunomarker for diagnosis in a case of acinic cell carcinoma of nasal cavity.…”