Synchrotron Radiation Computed Tomography applied to the Brain: Phantom Studies at the ESRF Medical Beamline

Charvet, Anne-Marie; Lartizien, Carole; Estève, François; Duc, Géraldine Le; Collomb, A.; Elleawne, H.; Fiedler, S.; Thompson, A.C.; Brochard, Thierry; Kleuker, Ulf; Steltner, H.; Spanne, P.; Suortti, P.; Bas, J.F. Le

doi:10.1007/978-4-431-68485-5_15

Cited by 5 publications

(5 citation statements)

References 7 publications

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“…This example could be applied to a number of pathologies, including genetic diseases, cancer, and diseases related to environmental factors and diagnosed late. Regarding medical applications, we moved from the use of very few hours on selected SR beamlines − to SR facilities fully dedicated to such applications …”

Section: Discussionmentioning

confidence: 99%

Characterization and Some Physicochemical Aspects of Pathological Microcalcifications

et al. 2012

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Section: Discussionmentioning

confidence: 99%

Characterization and Some Physicochemical Aspects of Pathological Microcalcifications

et al. 2012

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“…At synchrotron radiation facilities intense, monochromatic x-ray beams (energy spread <0.1 keV) can be extracted with continuity in a wide energy range (typically 10-100 keV). The technique has been validated and widely applied in radiography mode for coronary angiography (Rubenstein et al 1986, Thomlinson 1995, Dix 1995, Elleaume et al 1999 and in computed tomography (Thompson et al 1984, Dilmanian 1992, Charvet et al 1995, Dilmanian et al 1997.…”

Section: Introductionmentioning

confidence: 99%

Quantitative analysis of the effect of energy separation in k-edge digital subtraction imaging

Sarnelli¹,

Taibi²,

Baldelli³

et al. 2007

Phys. Med. Biol.

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The aim of the work is to quantitatively compare the effect of the energy separation in the k-edge digital subtraction imaging technique. Images of a custom-made, iodine filled (k-edge = 33.17 keV) test object have been acquired with monochromatic x-ray beams (energy spread <0.1 keV) at the ID17 biomedical beamline of the ESRF. Image acquisition has been performed using two energy separations, namely 0.65 keV (32.85 keV and 33.5 keV, respectively) and 4.4 keV (31.2 keV and 35.6 keV, respectively), using beams of energies on either side of the iodine k-edge. Signal and signal-to-noise ratio (SNR) analysis has been performed as a function of DeltaE and the contrast medium concentrations. The results show that the SNR values measured for DeltaE < 1 keV are only slightly higher than those measured for DeltaE = 4.4 keV. This preliminary study shows that monochromaticity and the energy separation obtained with quasi monochromatic beams from conventional x-ray sources might be suitable for this imaging technique.

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“…The use of synchrotron radiation provides several advantages over conventional methods for computed tomography (CT) (Thompson et al 1984, Dilmanian 1992, Charvet et al 1996. Sufficient intensity of monochromatic radiation is available to eliminate the effects of beam hardening, the energy can be tuned for optimum contrast versus radiation dose, and, due to the natural collimation of the beam, large distances between the object and the detector can be used to reject scatter.…”

Section: Computed Tomographymentioning

confidence: 99%

“…These are the dominant effects of attenuation and their relative importance can be changed by varying the x-ray energy. Low-and medium-Z images can be reconstructed from data taken at two or more energies (Charvet et al 1996. As mentioned earlier, scattered radiation can be used for tomographic imaging, and a multi-CT technique based on simultaneous detection of fluorescence and inelastic scattering has been described (Yuasa et al 1997).…”

Section: Computed Tomographymentioning

confidence: 99%

“…Structural studies of macromolecules, which form the foundation of modern biomedical research, have been revolutionized by synchrotron radiation, and it is expected that the same trend will be seen in other areas and for different length scales. Developments of synchrotron-based medical research have been reviewed at intervals of five years and overviews of research conducted at various facilities are published more frequently (Thomlinson 1992, Castelli 1996, Charvet et al 1996, Lewis 1997, Ando et al 1997. The present review is intended to make the latest possible results and complete set of references available.…”

Section: Introductionmentioning

confidence: 99%

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Medical applications of synchrotron radiation

2003

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The medical imaging and therapeutic technologies that are based on the use of radiation are reviewed briefly, with special emphasis on the recent developments of synchrotron radiation (SR) methods. New results have been achieved in all of these areas since the last comprehensive reviews were written in this field. This topical review is intended to make the latest possible results and complete set of references available. The different contrast mechanisms in imaging by x-rays are described. The applications range from whole-body imaging to studies of atomic and molecular structures. The SR imaging applications include coronary angiography, bronchography, mammography, computed tomography, x-ray microscopy and imaging by scattering. The therapy applications include photon activation therapy and microbeam radiation therapy.

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Synchrotron Radiation Computed Tomography applied to the Brain: Phantom Studies at the ESRF Medical Beamline

Cited by 5 publications

References 7 publications

Characterization and Some Physicochemical Aspects of Pathological Microcalcifications

Characterization and Some Physicochemical Aspects of Pathological Microcalcifications

Quantitative analysis of the effect of energy separation in k-edge digital subtraction imaging

Medical applications of synchrotron radiation

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