2007
DOI: 10.1063/1.2436445
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Synchrotron X-Ray Synthesized Gold Nanoparticles for Tumor Therapy

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Cited by 15 publications
(10 citation statements)
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“…Furthermore, GNPs can improve the contrast of the X-ray unit mammography through imaging the gold distribution in the tumor (Figure 13), which could be used to diagnose tumor earlier. Subsequently, similar results were reported by Chien et al, who used 20 nm gold nanoparticles as radiosensitizers for X-ray radiotherapy [151]. In Chang et al 's in vivo research, GNPs accumulation was observed inside cancer cells, which induced efficiency enhancement of ionizing radiation, cancer cell apoptosis, tumor growth inhibition, and a high chance survival of tumor-bearing mice [152].…”
Section: Gold Nanoparticle-aided Radiotherapysupporting
confidence: 56%
“…Furthermore, GNPs can improve the contrast of the X-ray unit mammography through imaging the gold distribution in the tumor (Figure 13), which could be used to diagnose tumor earlier. Subsequently, similar results were reported by Chien et al, who used 20 nm gold nanoparticles as radiosensitizers for X-ray radiotherapy [151]. In Chang et al 's in vivo research, GNPs accumulation was observed inside cancer cells, which induced efficiency enhancement of ionizing radiation, cancer cell apoptosis, tumor growth inhibition, and a high chance survival of tumor-bearing mice [152].…”
Section: Gold Nanoparticle-aided Radiotherapysupporting
confidence: 56%
“…The results indicated a DEF of 1.01 to 2.95 (1.44 ± 0.43) depending on the NPs type, NPs concentration, NPs size, cell line, radiation energy, and delivery condition. Table S1 30 - 106 (See online Supplementary file 1 ) summarizes the main results of the involved studies such as the NPs’ size, NPs’ concentration, cell line types, and radiation energy.The sensitizing characteristics of NPs have been established on various cell lines. To better compare the effect of different NPs concentrations, the reported concentrations in the articles were converted to the same unit (mM).…”
Section: Resultsmentioning
confidence: 99%
“…In the past decade, while a substantial number of studies have investigated radiosensitization by gold nanoparticles (GNPs) in vitro, little has been published on their radiosensitizing properties in vivo. [1][2][3][4][5][6][7][8][9][10] Tumor growth retardation or improvements in animal survival were observed only at very high doses of GNPs (∼2 g/kg) administered intravenously (IV) prior to tumor irradiation. 5,8 With much lower doses, ie, 13.5 mg of GNPs injected IV, no tumor growth retardation was measured in mice bearing murine mammary carcinoma.…”
Section: Introductionmentioning
confidence: 99%