Syndecan-1 - A new piece in B-cell puzzle

Kopper, László; Sebestyén, Anna; Gallai, Mónika; Kovalszky, Ilona

doi:10.1007/bf02899919

Cited by 13 publications

(14 citation statements)

References 101 publications

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“…We show that normal primary B lymphocytes express a broad repertoire of PG core proteins, with CD44 and serglycin as major PGs. Our data are in line with previously published results showing that CD44 [ 32 ], serglycin [ 9 – 11 ] and syndecan-1/CD138 [ 15 , 16 ] are expressed in B lymphocytes. In addition we demonstrate for the first time that B cells express additional proteoglycans (perlecan, glypican-1, CSPG4/NG2, decorin, biglycan, lumican) and a wide variety of PGs is consistently altered in EBV-carrying LCLs compared to primary B lymphocytes.…”

Section: Discussionsupporting

confidence: 93%

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Proteoglycan expression correlates with the phenotype of malignant and non-malignant EBV-positive B-cell lines

et al. 2015

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The involvement of proteoglycans (PGs) in EBV-host interactions and lymphomagenesis remains poorly investigated. In this study, expression of major proteoglycans (syndecan-1, glypican-1, perlecan, versican, brevican, aggrecan, NG2, serglycin, decorin, biglycan, lumican, CD44), heparan sulphate (HS) metabolic system (EXT1/2, NDST1/2, GLCE, HS2ST1, HS3ST1/2, HS6ST1/2, SULF1/2, HPSE) and extracellular matrix (ECM) components (collagen 1A1, fibronectin, elastin) in primary B cells and EBV carrying cell lines with different phenotypes, patterns of EBV-host cell interaction and viral latency stages (type I-III) was investigated. Primary B cells expressed a wide repertoire of PGs (dominated by serglycin and CD44) and ECM components. Lymphoblastoid EBV+ B cell lines (LCLs) showed specific PG expression with down-regulation of CD44 and ECM components and up-regulation of serglycin and perlecan/HSPG2. For Burkitt's lymphoma cells (BL), serglycin was down-regulated in BL type III cells and perlecan in type I BL cells. The biosynthetic machinery for HS was active in all cell lines, with some tendency to be down-regulated in BL cells. 5′-aza-dC and/or Trichostatin A resulted in transcriptional upregulation of the genes, suggesting that low expression of ECM components, proteoglycan core proteins and HS biosynthetic system is due to epigenetic suppression in type I cells. Taken together, our data show that proteoglycans are expressed in primary B lymphocytes whereas they are not or only partly expressed in EBV-carrying cell lines, depending on their latency type program.

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Section: Discussionsupporting

confidence: 93%

“…Thus, syndecan mediates B cell stage-specific adhesion [ 12 , 13 ]. Syndecan is expressed in chronic lymphocytic leukaemia B-CLL, both in tissue environment and in circulation [ 14 , 15 ]. Syndecan expression is not detected in normal and malignant T cells [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Proteoglycan expression correlates with the phenotype of malignant and non-malignant EBV-positive B-cell lines

et al. 2015

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“…TIN with IgM-positive cells is a new histologic entity with clinical features similar to the present case, such as RTA, Fanconi syndrome, high serum IgM levels and AMA positivity and one of its features is IgM-positive plasma cell (CD138-positive cell) infiltration (13)(14)(15). CD138 is an excellent marker of plasma cells (16,17), but it is also expressed in some B-chronic lymphocytic leukemia (18) and in body cavity-based lymphomas (primary effusion lymphomas) (19). Our case did not show clinical aspects of either of these entities.…”

Section: Discussionsupporting

confidence: 67%

Relapsing Tubulointerstitial Nephritis with Antimitochondrial M2 Antibody Accompanied by Pulmonary Involvement

et al. 2020

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We herein report a 50-year-old woman who suffered from tubulointerstitial nephritis with antimitochondrial M2 antibody, distal renal tubular acidosis, and Fanconi syndrome. Our case also had interstitial pneumonia. After initially successful glucocorticoid therapy, tubulointerstitial nephritis and interstitial pneumonia relapsed. After the second successful round of glucocorticoid therapy, tubulointerstitial nephritis relapsed again and responded to glucocorticoid and azathioprine. This case might indicate (1) the association between pulmonary involvement and tubulointerstitial nephritis with antimitochondrial antibodies and (2) the need for a maintenance dose of glucocorticoid and immunosuppressants in tubulointerstitial nephritis with antimitochondrial antibodies.

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“…In lymphoid cells, syndecan-1 is expressed in the late stages of differentiation, in pre-B cells and in Ig-producing plasma cells [15,16]. However, the exact role of syndecan-1 on lymphoid cells and the regulation of its expression is still mostly unknown.…”

Section: Introductionmentioning

confidence: 99%

Syndecan-1-Dependent Homotypic Cell Adhesion in HT58 Lymphoma Cells

Sebestyén¹,

Tótth²,

Rudolf³

et al. 2000

Tumor Biology

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Objectives: Many cellular functions are controlled by cell-cell and cell-matrix interactions. It has recently been found that syndecans, transmembrane heparan sulphate (HS) proteoglycans, can act as receptors or co-receptors and modulate cell adhesion. Our aim was to study the role of syndecan-1 in the aggregation of human lymphoma cells, and to investigate its effect on cell survival. Methods: Immunocytochemistry, confocal laser scanning microscopy, flow cytometry and aggregation/reaggregation bio-assays were used on HT58, BL41/95 and Raji lymphoma cell lines. Results: Bio-assays showed that the aggregation of HT58 cells was inhibited by heparin, HS, removal of the HS chain and binding of the anti-syndecan-1 monoclonal antibody. In the search for a counter-receptor of syndecan-1, several adhesion molecules were tested, but none of them proved to be the adhesion partner. In the case of heparitinase/trypsin digestion with long-term inhibition of HS synthesis (sodium chlorate treatment), the inhibited aggregation was accompanied by cell cycle arrest and the induction of apoptosis. Conclusions: The results obtained showed that surface syndecan-1 expression contributes to homotypic adhesion. In addition, HS chains, including those on syndecan-1, take part in the regulation of cell proliferation and active cell death in HT58 lymphoma cells.

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Syndecan-1 - A new piece in B-cell puzzle

Cited by 13 publications

References 101 publications

Proteoglycan expression correlates with the phenotype of malignant and non-malignant EBV-positive B-cell lines

Proteoglycan expression correlates with the phenotype of malignant and non-malignant EBV-positive B-cell lines

Relapsing Tubulointerstitial Nephritis with Antimitochondrial M2 Antibody Accompanied by Pulmonary Involvement

Syndecan-1-Dependent Homotypic Cell Adhesion in HT58 Lymphoma Cells

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