Syndecan-1 (CD138) and Ki-67 expression in different subtypes of ameloblastomas

Bologna‐Molina, Ronell; Mosqueda‐Taylor, Adalberto; López-Corella, Eduardo; Almeida, Oslei Paes de; Carrasco-Daza, Daniel; García-Vázquez, Francisco; Farfan-Morales, J.E.; Camacho, María Esther Irigoyen; Damián-Matsumura, Pablo

doi:10.1016/j.oraloncology.2007.10.007

Cited by 66 publications

(91 citation statements)

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“…Some authors reported that loss of CD138 (syndecan 1) expression in epithelial cells is associated with increased invasive and metastatic potential in some cancers (22,28). Recently, Bologno-Malina et al demonstrated that solid/ multicystic ameloblastomas had more aggressive biological behavior than the unicystic ameloblastomas (28).…”

Section: Discussionmentioning

confidence: 99%

“…Although there are several studies related to role of these proteins in odontogenic lesions in English literature (8,9,18,24,(27)(28)(29), no comparative and comprehensive study, in which the expression of these proteins or adhesion molecules in odontogenic cystic lesions have been evaluated, to our knowledge. Therefore, we aim to evaluate the immunohistochemical expressions of CD138 (syndecan-1), CD38, E-cadherin and survivin in these cystic odontogenic lesions and investigate the potential implications of their expressions among these lesions.…”

Section: Introductionmentioning

confidence: 99%

“…Our study revealed that E-cadherin expression was stronger in non-neoplastic odontogenic cysts (DCs and RCs) rather than neoplastic odontogenic cysts (CAs and KCOTs). These findings support this theory and are similar to the data of previous studies.Some authors reported that loss of CD138 (syndecan 1) expression in epithelial cells is associated with increased invasive and metastatic potential in some cancers (22,28). Recently, Bologno-Malina et al demonstrated that solid/ multicystic ameloblastomas had more aggressive biological behavior than the unicystic ameloblastomas (28).…”

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Immunohistochemical characteristics of cystic odontogenic lesions: a comparative study

Özcan

Yavan²,

Günhan³

2015

TJPATH

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Objective: Cystic ameloblastoma, keratocystic odontogenic tumor, dentigerous cyst, and radicular cyst are the most commonly encountered cystic odontogenic lesions. The aim of this study was to investigate the expressions of survivin, E-cadherin, CD138, and CD38 in these lesions and their potential diagnostic usage. Material and Method:A total of 20 cases, consisting 5 radicular cysts, 5 dentigerous cysts, 5 keratocystic odontogenic tumors and 5 cystic ameloblastomas were included in our series. For all cases, sections from the selected blocks were stained against the antibodies for survivin, E-cadherin, CD138, and CD38 on an automated device.Results: All cystic ameloblastomas and keratocystic odontogenic tumors showed diffuse and strong nuclear survivin expression. No specific survivin immunoreactivity was observed in the dentigerous and radicular cysts. E-cadherin expression was stronger in all dentigerous cysts and radicular cysts when compared to others. CD138 expression in stromal cells was prominent in cystic ameloblastomas, but gradually decreased in the other three lesions. All cases were negative for CD38. Conclusion:In the present study, loss of E-cadherin expression in epithelial cells, strong CD138 expression in stromal cells and strong nuclear survivin expression both in epithelial and stromal cells in cystic ameloblastomas and keratocystic odontogenic tumors were the most remarkable findings. These findings are also reinforced by the studies suggesting their role in the aggressiveness and pathogenesis of these tumors. Key Words: Odontogenic tumors, Odontogenic cysts, Immunohistochemistry ÖzAmaç: Kistik ameloblastoma, keratokistik odontojenik tümör, dentijeröz kist ve radiküler kist en sık karşılaşılan kistik odontojenik lezyonlardır. Çalışmada bu lezyonlarda survivin, E-cadherin, CD138 ve CD38 ekspresyonları ve bunların potansiyel tanısal kullanımları araştırılmıştır. Gereç ve Yöntem:Çalışma serimiz 5 kistik ameloblastoma, 5 keratokistik odontojenik tümör, 5 dentijeröz kist ve 5 radiküler kist olmak üzere toplam 20 olgudan oluşmaktadır. Bütün olgulara ait seçilmiş bloklardan sağlanan kesitler otomatize bir cihazda survivin, E-cadherin, CD138, and CD38 antikorları ile boyandı. Bulgular:Kistik ameloblastoma ve keratokistik odontojenik tümörlerin hepsi yaygın ve kuvvetli nükleer survivin ekspresyonu gösterdi. Dentijeröz ve radiküler kistlerde spesifik survivin ekspresyonu gözlenmedi. E-cadherin ekspresyonu diğer lezyonlarla karşılaştırıldığında, dentijeröz ve radiküler kistlerde daha belirgindi. CD138 ekspresyonu kistik ameloblastomalarda stromal hücrelerde daha belirgindi, ancak diğer lezyonlarda giderek azalan oranlardaydı. CD38 olguların hepsinde negatifdi.Sonuç: Çalışmada, keratokistik odontojenik tümörlerde ve kistik ameloblastomada epitelyal hücrelerde E-cadherin kaybı, stromal hücrelerde kuvvetli CD138 ekspresyonu ve hem epitelyal hem de stromal hücrelerde kuvvetli nükleer survivin ekspresyonu en karakteristik bulgulardır. Bu bulguların bu tür lezyonların patogenezini ve agresif davranış...

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Immunohistochemical characteristics of cystic odontogenic lesions: a comparative study

Özcan

Yavan²,

Günhan³

2015

TJPATH

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“…Several studies have demonstrated that peripheral ameloblastomas may present indolent behavior compared with the central variant (10,22,23). Thus, the treatment of choice is a conservative supraperiosteal excision with adequate disease-free margins (1,4).…”

Section: Discussionmentioning

confidence: 99%

Peripheral Ameloblastoma with Dystrophic Calcification: An Unusual Feature in Non-Calcifying Odontogenic Tumors

et al. 2014

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Peripheral ameloblastoma is a rare extraosseous counterpart of central ameloblastoma that occurs in soft tissues and may cause bone crest resorption. This study reports a peripheral ameloblastoma on the buccal gingiva of a 56-year-old man, which presented extensive squamous metaplasia areas, keratinization and dystrophic calcifications in the neoplastic islands. It is emphasized the need of a detailed imaging study and a long follow-up period to exclude bone involvement whenever peripheral ameloblastoma diagnosis is considered. P e r i p h e r a l A m e l o b l a s t o m a with Dystrophic Calcification:A n U n u s u a l F e a t u r e i n N o nCalcifying Odontogenic Tumors

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“…[5] BolognaMolina et al (2008) found reduced expression of SDC1 in solid ameloblastoma (SA) and correlated with its more aggressive biological behavior when compared to unicystic ameloblastoma (UA). [6] Al-Otaibi et al, (2013) studied SDC-1 immunoreactivity in the stromal cells of AB, keratocystic odontogenic tumor (KCOT), and dentigerous cysts and it was suggested that the SDC-1 expression by the tumor stroma is considered to be associated with poor prognosis of the lesions. [7] Heikinheimo et al, (1991) stated that there is an association between the stronger labeling of α5β1 integrin in the neoplastic cells of ABs and greater migration capacity of these cells because of increased fi bronectin expression in stromal cells.…”

Section: Clonalitymentioning

confidence: 99%

Molecular etiopathogenesis of ameloblastoma – current concepts revisited

Spandana¹,

Someshwar²,

Sekhar³

et al. 2015

JMRPS

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The ameloblastoma (AB) is a true neoplasm of enamel organ type tissue which does not undergo diff erentiation to the point of enamel formation. AB is locally invasive and recurs despite adequate surgical removal. It is of varied origin, although the stimulus initiating the process is unknown. The study of molecular and genetic alterations associated with the development and progression of the AB will help to predict the course of the tumor and lead to the development of new therapeutic concepts for their management. An attempt has been made at compiling about molecular pathogenesis of AB.

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Syndecan-1 (CD138) and Ki-67 expression in different subtypes of ameloblastomas

Cited by 66 publications

References 39 publications

Immunohistochemical characteristics of cystic odontogenic lesions: a comparative study

Immunohistochemical characteristics of cystic odontogenic lesions: a comparative study

Peripheral Ameloblastoma with Dystrophic Calcification: An Unusual Feature in Non-Calcifying Odontogenic Tumors

Molecular etiopathogenesis of ameloblastoma – current concepts revisited

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