Peripheral Ameloblastoma with Dystrophic Calcification: An Unusual Feature in Non-Calcifying Odontogenic Tumors

Abstract

Peripheral ameloblastoma is a rare extraosseous counterpart of central ameloblastoma that occurs in soft tissues and may cause bone crest resorption. This study reports a peripheral ameloblastoma on the buccal gingiva of a 56-year-old man, which presented extensive squamous metaplasia areas, keratinization and dystrophic calcifications in the neoplastic islands. It is emphasized the need of a detailed imaging study and a long follow-up period to exclude bone involvement whenever peripheral ameloblastoma diagnosis is considered. P e r i p h e r a l A m e l o b l a s t o m a with Dystrophic Calcification:A n U n u s u a l F e a t u r e i n N o nCalcifying Odontogenic Tumors

Ameloblastoma with dystrophic calcification: A case report with 3-dimensional cone-beam computed tomographic images of calcification

“…A PubMed search yielded 4 reports describing a total of 5 cases of ameloblastoma with calcification in the oral and maxillofacial region. [5][6][7][8] Histopathologically, 5 cases (including the present case) were acanthomatous, while 1 case was follicular ameloblastoma. Although calcification in ameloblastoma was first re-ported in 1958, 5 it is an uncommon feature.…”

“…10 These developmental and histologic relationships among craniopharyngioma, COC, and ameloblastoma might explain why this case of ameloblastoma was accompanied by calcification. Previous reports regarding calcification of ameloblastoma [5][6][7][8] mainly presented histopathologic findings of calcification. However, in this case, calcification could be detected on panoramic radiography as faint radiopaque foci dispersed in the cavity, and CBCT images clearly showed somewhat round, varying-sized calcified foci.…”

Immune cell infiltration in gingival epithelioid angiomatous nodule: Case report and immunohistochemical analysis

“…Peripheral odontogenic fibroma, which represents the soft tissue counterpart of central odontogenic fibroma, is a benign odontogenic neoplasm, histologically presentating mature collagenous fibrous tissue in addition to odontogenic epithelium [10]. Likewise, peripheral counterpart of central lesion, the peripheral ameloblastomas are lesions of indolent behavior and microscopically exhibit the same histopathological subtypes from central lesions [16]. Microscopically, the differentiation of EAN from mimickers is complex and the differential diagnosis should include epithelioid hemangioma (EH), epithelioid hemangioendothelioma (EHE) and epithelioid angiosarcoma (EA) [6].…”

Evaluation of midkine expression in dentigerous cysts, odontogenic keratocysts and different types of ameloblastoma

“…The etiology is still unknown. Its occurrence rate is estimated to be 0.5 in one million in a year; however, this number is estimated to be much higher in some regions such as South Africa (4)(5)(6). Most patients are 30-60 years old when diagnosed.…”