Syndecan-2 regulates cell migration in colon cancer cells through Tiam1-mediated Rac activation

Choi, Youngsil; Kim, Hyun-Jung; Chung, Heesung; Hwang, Ji Sun; Shin, Jeong-Ah; Han, Inn Oc; Oh, Eok Soo

doi:10.1016/j.bbrc.2009.11.165

Cited by 47 publications

(31 citation statements)

References 25 publications

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“…5H). Syndecan-2 expression has been shown to regulate the migration of colon cancer cells through Tiam1-dependent Rac1 activation (17), and syndecan-2 dimerization was found to play a fundamental role in this signaling (17,18). Consistent with this, we found that wild-type syndecan-2 promoted the activation (GTP binding) of Rac1 in HCT116 cells, whereas S2(F167I) and 2E4T2C had much more limited effects (Fig.…”

Section: Journal Of Biological Chemistrysupporting

confidence: 82%

“…For example, whereas wild-type syndecan-4 can regulate cytoskeletal organization, its dimerization-deficient mutant showed decreased binding with ␣-actinin and less activation of PKC␣ and RhoA (15,16). The TMD-TMD association is also important for syndecan-2-mediated functions, including the activation of Rac in colon cancer, increased cell migration, and the interaction with syntenin (17,18).…”

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confidence: 99%

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A Unique Phenylalanine in the Transmembrane Domain Strengthens Homodimerization of the Syndecan-2 Transmembrane Domain and Functionally Regulates Syndecan-2

Kwon

Choi

Yun

et al. 2015

Journal of Biological Chemistry

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Background:The transmembrane domains of syndecan family members harbor a GXXXG motif forming non-covalently linked SDS-resistant dimers. Results: A unique phenylalanine in the syndecan-2 transmembrane domain contributes to its transmembrane homointeraction and unique functions. Conclusion: A unique phenylalanine in syndecan-2 endows its transmembrane domain with specific functions. Significance: This report provides insight into the importance of the transmembrane domain for syndecan receptor function.

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Section: Journal Of Biological Chemistrysupporting

confidence: 82%

mentioning

confidence: 99%

A Unique Phenylalanine in the Transmembrane Domain Strengthens Homodimerization of the Syndecan-2 Transmembrane Domain and Functionally Regulates Syndecan-2

Kwon

Choi

Yun

et al. 2015

Journal of Biological Chemistry

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“…The protein plays a major role in the interaction of cells and extracellular matrix proteins and regulates cytoskeletal organization. Thus, syndecan-2 controls the migration of various types of cancer cells including different lines of colon cancer cells (16,17) and fibrosarcoma cells (18). Recently, we reported that the syndecan-2 level was increased in melanoma cells and that this increase critically affected the migratory potential of such cells (19).…”

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confidence: 99%

Melanocortin 1 Receptor Regulates Melanoma Cell Migration by Controlling Syndecan-2 Expression

Chung

Lee

Jeong

et al. 2012

Journal of Biological Chemistry

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Background:The melanocortin 1 receptor is known to regulate inflammation. Results: The melanocortin 1 receptor inhibits activation of p38 MAPK, subsequently enhancing syndecan-2 expression and migration in melanoma cells. Conclusion:The melanocortin 1 receptor regulates melanoma cell migration by controlling syndecan-2 expression. Significance: This work shows the melanocortin 1 receptor plays a role during cell migration.

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“…ARPC1A, a new tumor-related gene, was also affected by MR-1 expression levels. This is an actin-related protein and has been found to be an important regulator of cell motility and invasion is in pancreatic cancer cells [22,23]. Altogether, there were a number of important genes related to cell adhesion; invasion and spreading that were regulated by MR-1 expression.…”

Section: Discussionmentioning

confidence: 96%

Myofibrillogenesis regulator-1 promotes cell adhesion and migration in human hepatoma cells

Zhao

Ren

et al. 2013

Chin. Sci. Bull.

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Myofibrillogenesis regulator-1 (MR-1) is a gene overexpressed usually in many human cancers. However, the effects of MR-1 on cell proliferation, adhesion, migration and genome-wide gene regulation are still unclear. In this study, a human hepatoma cell line that highly overexpresses MR-1, BEL-7402/MR-1 cells was established. While the high expression of MR-1 did not promote cell proliferation, it significantly increased cell spreading, adhesion and migration compared with control cells. A total of 147 genes were regulated by MR-1 expression, 46 genes were down-regulated and 101 genes were up-regulated by MR-1 overexpression. Many of these genes were related to cell adhesion, cytoskeletal regulation, MAPK signaling, and cell cycle related pathways. Western blot analysis further confirmed the regulation of pathways associated with migration by MR-1. These results suggest that MR-1 is involved in the regulation of cancer cell adhesion, migration and related gene expression.

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Syndecan-2 regulates cell migration in colon cancer cells through Tiam1-mediated Rac activation

Cited by 47 publications

References 25 publications

A Unique Phenylalanine in the Transmembrane Domain Strengthens Homodimerization of the Syndecan-2 Transmembrane Domain and Functionally Regulates Syndecan-2

A Unique Phenylalanine in the Transmembrane Domain Strengthens Homodimerization of the Syndecan-2 Transmembrane Domain and Functionally Regulates Syndecan-2

Melanocortin 1 Receptor Regulates Melanoma Cell Migration by Controlling Syndecan-2 Expression

Myofibrillogenesis regulator-1 promotes cell adhesion and migration in human hepatoma cells

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