Syndrome of Inappropriate Antidiuretic Hormone Associated with Eosinophilic Granulomatosis with Polyangiitis

Tokushige, Shin‐ichi; Kodama, Kako; Hideyama, Takuto; Kumekawa, Hanae; Shimizu, Jun; Maekawa, Risa; Shiio, Yasushi

doi:10.2169/internalmedicine.55.5122

Cited by 5 publications

(3 citation statements)

References 11 publications

(9 reference statements)

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“…SIADH can be associated with a large number of underlying pathologies, with central nervous system disturbances, malignancies and drugs being the most common etiologies 4. However, we were able to find only three cases of SIADH documented occurring in association with EGPA, all in Japan 5–7. Our patient was Caucasian.…”

Section: Discussionmentioning

confidence: 62%

Syndrome of inappropriate antidiuretic hormone associated with eosinophilic granulomatosis and polyangiitis

2020

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A 62-year-old man presented with classic signs and symptoms of eosinophilic granulomatosis and polyangiitis (EGPA, also known as Churg-Strauss syndrome)—mononeuritis multiplex, palpable purpura, hypereosinophilia, positive P-ANCA (perinuclear anti-neutrophil cytoplasmic antibodies) developed diffuse alveolar haemorrhage. The patient had longstanding mild hyponatraemia, but developed moderate and symptomatic hyponatraemia characteristic of the syndrome of inappropriate antidiuretic hormone. The patient’s serum sodium returned to his baseline- mildly hyponatraemic, after initiation of treatment targeted towards EGPA.

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Section: Discussionmentioning

confidence: 62%

Syndrome of inappropriate antidiuretic hormone associated with eosinophilic granulomatosis and polyangiitis

2020

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“…Lundin et al [ 6 ] reported a case of a 62-years-old male with hyponatremia resulting from the prolonged medication for allergic asthma with a serum sodium of 120 mmol/L and positive perinuclear anti-neutrophil cytoplasmic antibodies, ultimately considered to result from the syndrome of inappropriate antidiuretic hormone eliciting eosinophilic granulomatosis and polyangiitis. In addition, Tokushige et al [ 7 ] demonstrated that polyangiitis may cause some damage to the hypothalamus or posterior pituitary, inducing arginine vasopressin dysfunction.…”

Section: Discussionmentioning

confidence: 99%

A case report of posterior reversible encephalopathy syndrome caused by ANCA-associated vasculitis case report and retrospective analysis

et al. 2022

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Introduction: Posterior reversible encephalopathy syndrome is a reversible syndrome clinically manifested by significant variations in neuroimaging. Early treatment is indispensable to achieve the reversibility, which requires the punctual alleviation of its inducing factors.Patient concerns: Most symptoms of posterior reversible encephalopathy syndrome (PRES) patients can be dispelled followed by a good prognosis after the inducement removal. The patient died due to the untimely diagnosis and treatment of the primary disease. Therefore, sufficient attention should be paid to the PRES induced by ANCA-associated vasculitis (AAV). Diagnosis and interventions:The patient is a middle-aged male, with acute onset, previous history of hypertension, cholecystectomy, intestinal obstruction, spontaneous renal rupture, etc. For this complaint, the manifestations are mainly blurred vision with convulsion and transient disturbance of consciousness. In 1 day of treatment, these symptoms were relieved, and he was diagnosed as PRES combined with the cranial imaging. The AAV of the patient was confirmed by spleen pathology.Outcomes: Despite the relief of most symptoms in 1 day of symptomatic treatment, it is highly likely that the patient eventually died of AAV, it is highly likely that the patient eventually died of AAV which will invade the vascular system due to the failure to treat the primary disease in time.Lessons: For patients diagnosed as PRES, the punctual identification of cause should be performed, so as to diagnose and correct the cause and primary disease as soon as possible, accompanied with the dynamical observation of the relevant indicators for suspected patients to avoid systemic organ failure.Abbreviations: AAV = ANCA-associated vasculitis, ANCA = antineutrophil cytoplasmic antibody, CT = computed tomography, PRES = posterior reversible encephalopathy syndrome.

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“…EGPA could be associated with inappropriate antidiuretic hormone syndrome[59]. EGPA categorized into two different clinical phenotypes according to the type/level of autoantibodies patient serum, ANCAnegative EGPA and anti-MPO-ANCA EGPA.…”

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confidence: 99%

ANCA-Associated Vasculitis: Advancement in Pathogenesis, Clinical Features and Management

Azab

Safi

Wang

2019

BJSTR

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Anti-Neutrophil Cytoplasmic Autoantibody (ANCA)-Associated Vasculitides (AAVs) are rare disorders characterized by inflammation of the small blood vessels resulting in ischemia or haemorrhage. The main phenotypes of AAVs are Granulomatosis with Polyangiitis (GPA), Microscopic Polyangiitis (MPA), and Eosinophilic Granulomatosis with Polyangiitis (EGPA). Although the pathogenesis of these disorders is still incompletely understood, distinct roles for T cells subsets and ANCA autoantibodies were underscored. AAVs present in the head, neck, lung, kidney, skin, heart, eyes, and intestine. The treatment of AAVs aims to induce and maintain remission and rapidly control of the disease activity. Rituximab, the first major alternative to cyclophosphamide plus glucocorticoids therapy, has enhanced the management of AAVs. However, continuous evaluation is constantly needed to manage the uncommon clinical features which may accompany the disease. This review summarizes the major findings of recent studies related to the three kinds of AAVs focusing on new novelties of their pathogenesis, clinical manifestations, and management.

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Syndrome of Inappropriate Antidiuretic Hormone Associated with Eosinophilic Granulomatosis with Polyangiitis

Cited by 5 publications

References 11 publications

Syndrome of inappropriate antidiuretic hormone associated with eosinophilic granulomatosis and polyangiitis

Syndrome of inappropriate antidiuretic hormone associated with eosinophilic granulomatosis and polyangiitis

A case report of posterior reversible encephalopathy syndrome caused by ANCA-associated vasculitis case report and retrospective analysis

ANCA-Associated Vasculitis: Advancement in Pathogenesis, Clinical Features and Management

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