Syndrome of Inappropriate Antidiuretic Hormone Secretion and Herpes zoster Infection: 1. Report of this Association in a Patient Suffering from AIDS

Abstract

The syndrome of inappropriate secretion of antidiuretic hormone is a common consequence of neurologic and pulmonary infections as well as drug intake and many other clinical situations. Its association with herpes varicella-zoster virus infections is scarcely reported in the literature. It generally appears in immunosuppressed patients suffering from serious underlying diseases. There are also a few cases of syndrome of inappropriate secretion of antidiuretic hormone related to vidarabine use. We report the case of a man infected by human immunodeficiency virus who developed a disseminated herpes varicella-zoster virus infection and symptoms due to hyponatremia caused by antidiuretic hormone excess. The patient was cured with saline hypertonic infusion, water restriction, and intravenous administration of acyclovir. To the best of our knowledge, this is the first case of this association in a human immunodeficiency virus infected patient. We propose the use of acyclovir instead of vidarabine in the management of these situations.

Disseminated zoster, hyponatraemia, severe abdominal pain and leukaemia relapse: recognition of a new clinical quartet after bone marrow transplantation

“…The mortality rate was high, partly due to late diagnosis, with a long lag phase before the appearance of the skin lesions. Most patients were also immunocompromised due to human immunodeficiency virus, chronic illness or chemotherapy 5,6 . In two‐thirds of cases, SIADH was documented.…”