Syndrome of Inappropriate Antidiuretic Hormone in a Bulldog with Aspiration Pneumonia

Bowles, K.D.; Brainard, B.M.; Coleman, Kevin D.

doi:10.1111/jvim.12577

Cited by 11 publications

(3 citation statements)

References 22 publications

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“…In veterinary medicine, SIADH has been reported in dogs due to neurological diseases, including congenital hydrocephalus, granulomatous amebic meningoencephalitis, and hypothalamic tumors 5–7 . Other associated diseases reported include heartworm, aspiration pneumonia, histiocytic sarcoma, and liver disease 8–11 . Two cases reported in the veterinary literature were suspected to be idiopathic 12 …”

Section: Introductionmentioning

confidence: 99%

Syndrome of inappropriate antidiuretic hormone secretion secondary to trauma in a dog

Cilli

Bellis

2021

J Vet Emergen Crit Care

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Objective To describe a case of inappropriate antidiuretic hormone (ADH) secretion in a dog secondary to trauma. Case Summary A 14‐year‐old neutered female mixed breed dog presented for evaluation of bite wounds. The dog sustained multiple puncture wounds to the cervical area, stifle, and elbow. Treatment was initiated with isotonic crystalloid fluids, analgesia, broad‐spectrum antimicrobials, and gastroprotectants. The dog developed hyponatremia with concurrent serum hypoosmolality and inappropriate urine hyperosmolality and urine sodium secretion, leading to a diagnosis of the syndrome of inappropriate ADH secretion. The hyponatremia improved, and the dog improved clinically and was discharged 3 days after admission. New or Unique Information Provided This is the first case description of the syndrome of inappropriate ADH secretion in a dog suffering from trauma. Inappropriate ADH secretion is largely under‐recognized in veterinary patients. Increased awareness of this syndrome can lead to initiation of appropriate treatment and improved outcomes.

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Section: Introductionmentioning

confidence: 99%

Syndrome of inappropriate antidiuretic hormone secretion secondary to trauma in a dog

Cilli

Bellis

2021

J Vet Emergen Crit Care

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“…Other causes of SIADH in humans include pain (especially post-operative), severe nausea, and stress (11, 15). In dogs, SIADH has been recognised in only a few animals of various breeds and both sexes, and it was concurrent to aspiration pneumonia, liver disease, granulomatous amoebic meningoencephalitis, congenital hydrocephalus, and histiocytic sarcoma (5, 6, 7, 19, 22, 29). SIADH in dogs may also be idiopathic as in humans and this was diagnosed in two dogs (25).…”

Section: Introductionmentioning

confidence: 99%

Hyponatraemia and syndrome of inappropriate antidiuretic hormone secretion in non-azotaemic dogs with babesiosis associated with decreased arterial blood pressure

Gójska-Zygner¹,

Bartosik

Górski

et al. 2019

Journal of Veterinary Research

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Introduction A previous study on canine babesiosis showed low serum tonicity in affected dogs, which may result from syndrome of inappropriate antidiuretic hormone secretion (SIADH). This endocrine disorder was recognised in human malaria which is considered a disease with similar pathogenesis to canine babesiosis. The aim of this study was to investigate the occurrence of SIADH in babesiosis-afflicted dogs. Material and Methods Serum and urinary sodium and urine specific gravity (USG) were determined in dogs with babesiosis. Mean arterial pressure (MAP) was measured at the beginning of the clinical examination. Serum tonicity and osmolality were calculated. Correlations were calculated between MAP and serum and urinary sodium concentrations, USG, serum tonicity, and calculated serum osmolality. Results Statistically significant correlations were observed between MAP and tonicity, calculated osmolality, USG, and serum and urinary sodium concentrations in non-azotaemic dogs. In three non-azotaemic dogs SIADH was recognised. Conclusion SIADH develops in non-azotaemic dogs with babesiosis. It is probably associated with decreased blood pressure in infected dogs. Thus, it seems that in fact it may be appropriate vasopressin secretion in canine babesiosis as a protective mechanism in hypotension which leads to hypoxia and renal failure in affected dogs.

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“…It selectively blocks vasopressin, leading to reduced water reabsorption and diuresis, while maintaining electrolyte balance [ 16 ]. SIADH cases in dogs are rarely reported, and apart from addressing the underlying condition, treatment has mainly involved water restriction and intravenous fluids [ 1 , 3 , 17 ]. While a previous report mentioned the use of the V2 receptor antagonist Mozavaptan (OPC-31260), there is no established pharmacological treatment for dogs [ 7 ].…”

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confidence: 99%

Effect of tolvaptan on hyponatremia in a dog with syndrome of inappropriate secretion of antidiuretic hormone

et al. 2023

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A 1-year-old spayed female Miniature Schnauzer had chronic hyponatremia, accompanied by polyuria and polydipsia. Blood tests and urinalysis revealed severe hyponatremia, low plasma osmolality with euvolemia, and increased sodium excretion in urine. Hypothyroidism and hypoadrenocorticism were ruled out as causes. These findings led to the diagnosis of syndrome of inappropriate secretion of antidiuretic hormone (SIADH). Magnetic resonance imaging (MRI) showed dilation of the lateral ventricles, indicating severe hydrocephalus. Tolvaptan, a vasopressin V2 receptor antagonist commonly used in human SIADH, was administered along with water restriction. This treatment resulted in a consistent increase in plasma sodium levels without any adverse effects. This case report represents the first documented evidence of the therapeutic efficacy of tolvaptan in treating SIADH in a dog.

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Syndrome of Inappropriate Antidiuretic Hormone in a Bulldog with Aspiration Pneumonia

Cited by 11 publications

References 22 publications

Syndrome of inappropriate antidiuretic hormone secretion secondary to trauma in a dog

Syndrome of inappropriate antidiuretic hormone secretion secondary to trauma in a dog

Hyponatraemia and syndrome of inappropriate antidiuretic hormone secretion in non-azotaemic dogs with babesiosis associated with decreased arterial blood pressure

Effect of tolvaptan on hyponatremia in a dog with syndrome of inappropriate secretion of antidiuretic hormone

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