Syndrome of Remitting Seronegative Symmetrical Synovitis with Pitting Edema (RS3PE)

Abstract

Abst ract RS3PE (remitting seronegative, symmetric synovitis with pitting edema) is a benign, seronegative syndrome, with an acute onset of pitting edema on the dorsum of both hands and feet, which affects predominantly peripheral joints such as wrists and ankles symmetrically. A 58-year-old man presented with acute symmetrical polysynovitis of the wrists and ankles associated with pitting edema on the dorsum of the both hands and feet. He responded well to low-dose corticosteroids. There was no evidence of erosion radiologically. The clinical manifestations of the patient were consistent with RS3PE syndrome. Here, we present a case of RS3PE and review the literature. (Turk J Rheumatol 2010; 25: 88-90

Idiopathic, remitting, seronegative, symmetrical synovitis with pitting oedema (RS3PE) – an overlooked clinical entity?

“…Interleukin-6 has been found to be high in the synovial fluid of patients. HLA (HLA-B7, HLA-B22, HLA-B27, HLA-A2, HLA-CW7, HLA-DQW2) is found to be associated with RS3PE [7,8]. A definite triggering factor for the development of RS3PE has not been established.…”

Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome

“…Otherwise, amyloidal arthropathy can cause pitting edema, but this is progressive and irreversible 40,41 . Rarely, RS3PE might be associated with drugs such as rifampicin, dipeptidyl peptidase-4 inhibitors, insulin and intravesical bacillus Calmette-Guérin (BCG) treatment 12 proposed the following diagnostic criteria in 1997: i) age above 50, ii) negative RF, iii) pitting edema of both hands, iv) acute onset polyarthritis 45,46 .…”

Coexistence of RS3PE Syndrome and Ankylosing Spondylitis in a Young Male

“…RS3PE sendromunda, prognozun genel olarak son derece iyi olduğu kabul edilmesine rağmen bazı maligniteler gelişmesi kareketeristik bir özelliğidir. RS3PE sendromuyla bağlantılı olarak hematolojik (lösemi, lenfoma), myelodisplastik sendrom [6] ve gastrik, pankreas kanseri gibi maligniteler gelişebilmektedir [20). Bizim olgumuz steroide çok dramatik bir yanıt verdi ve kliniğinde malignite bulgusuna rastlanmadı.…”