Syndromes associated with dental agenesis

Santis, Daniele De; Sinigaglia, S.; Faccioni, P; Pancera, P; Luciano, U; Bertossi, Dario; Lucchese, Alessandra; Aglietta, Massimo; Nocini, Pier Francesco

doi:10.23736/s0026-4970.18.04129-8

Cited by 10 publications

(12 citation statements)

References 58 publications

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“… A: schematic representation of tooth numbering according to the Fédération Dentaire Internationale (FDI) system [ 48 ] TAC % percentage TAC values according to tooth type * Presence of wisdom teeth was not included …”

Section: Resultsmentioning

confidence: 99%

“… Patients with a panoramic radiograph and a lateral cephalograms according to the ALARA (as low as reasonably achievable) principles with an indication justifying radiation exposure within the course of orthodontic treatment. The exclusion criteria were defined as follows: Additional associated complex congenital malformations (syndromes) or mental retardation, due to the fact that some syndromes are associated with tooth agenesis [ 48 , 49 ]. Patients younger than 5 years and older than 18 years.…”

Section: Methodsmentioning

confidence: 99%

“…Additional associated complex congenital malformations (syndromes) or mental retardation, due to the fact that some syndromes are associated with tooth agenesis [ 48 , 49 ].…”

Section: Methodsmentioning

confidence: 99%

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Tooth agenesis in German orthodontic patients with non-syndromic craniofacial disorder: a retrospective evaluation of panoramic radiographs

et al. 2022

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Objectives The study objective was to evaluate the tooth agenesis in German orthodontic patients with non-syndromic cleft lip and/or palate and Robin sequence compared to a control group without craniofacial disorder. Materials/methods A total of 108 panoramic radiographs were examined using the binary system of Tooth Agenesis Code (TAC) (excluding the third molar). Patients were divided into the craniofacial disorder group 1 (n = 43) and the healthy control group 2 (n = 65). Parameters such as skeletal class malformation, sex, localization of the cleft, craniofacial disorder, and interobserver reliability were assessed. Results Permanent tooth agenesis was observed in 44% of group 1 and 14% in group 2 with a statistically significant higher prevalence (p = 0.00162 (χ2)). Fourteen different TAC patterns were observed in group 1, ten of these occurring only once in separate patients. The distribution of the TAC codes in group 2 showed nine different possibilities of TAC code patterns; seven TACs were unique. In group 1, the most frequently absent teeth were the maxillary lateral incisor of the left side (30%); in group 2, the second premolar of the lower jaw on the right side (9%). Male patients with craniofacial disorder showed a higher percentage of tooth agenesis than female. Conclusion The data presented here shows a statistically significant higher prevalence of tooth agenesis in German patients with non-syndromic craniofacial disorder. Clinical relevance Radiographic evaluation enables the diagnosis of tooth agenesis. Recognizing early on the higher prevalence of tooth agenesis in patients exhibiting a craniofacial disorder is an important issue when developing long-term and comprehensive interdisciplinary treatment.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Tooth agenesis in German orthodontic patients with non-syndromic craniofacial disorder: a retrospective evaluation of panoramic radiographs

et al. 2022

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“…Dental agenesis occurs in primary and permanent dentition, usually in the case of third molars, mandibular second premolars, maxillary lateral incisors, and maxillary second premolars, [1][2][3] as a sporadic spontaneous de novo mutation 4 or as familial hypodontia, mainly due to autosomal dominant inheritance, 5 but also as part of a syndromic condition, 6 as a phenotypic feature of common conditions, such as Down syndrome or ectodermal dysplasia, 7,8 isolated or as part of complex syndromes, like labio-palatal cleft 8,9 or oral-facial-digital syndrome type I. 7,10 Other causative factors are environmental factors (radiotherapy, chemotherapy, the disease or infection of the primary tooth, tobacco consumption) or host factors (viral infection during pregnancy, metabolic imbalance).…”

Section: Introductionmentioning

confidence: 99%

Infraocclusion level and root resorption of the primary molar in second premolar agenesis: A retrospective cross-sectional study in the Portuguese population

Calheiros-Lobo¹,

Costa²,

Pinho³

2022

Dent. Med. Probl.

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Background. Mandibular second premolar (M2P) agenesis results in the second primary molar (2pm) retention, infraocclusion, a reduced alveolar height and width, the supraeruption of antagonists, or the movement of the adjacent teeth. Infraocclusion affects the survival of the retained 2pm to a greater extent than root resorption.Objectives. The aim of the study was to evaluate the lifespan of the primary molar as a substitute, with root quality and occlusal adaptation, in cases of M2P agenesis in a low-income population to determine if the attitude of just vigilance could be the best clinical option whenever other clinical problems are absent. Material and methods.A total of 12,949 orthopantomograms were analyzed. Sixty-one patients (25 males and 36 females aged 7-36 years were divided into group 1 (the first permanent molar in occlusion) and group 2 (the second permanent molar also in occlusion). Vertical positioning to the occlusal plane, root condition and the movement of the adjacent teeth were evaluated.Results. Despite the study having a cross-sectional design, root resorption, infraocclusion, the distance between the first permanent molar and the first primary molar or the first permanent premolar, and the width of the 2pm were correlated with age. The primary molar root resorption increased with age, which was more pronounced when the second permanent molar was also in occlusion. The mesial movement of the adjacent teeth was absent in all groups. The 2pm was often occluded, but infraocclusion increased with age. Age periods of 11-15 years and 21-25 years are critical for the primary tooth loss. Conclusions.The second primary molar remains functional in the mandibular arch for up to 25 years. A well-documented no-intervention attitude based on clinical and radiographic data must be weighted in cases without orthodontic issues or with financial constraints.

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“…During the early stages of tooth formation, disturbances can result in hipodontia, which could be part of a syndrome (Down sy, Rieger and Book sy [17][18][19] ), occurs in patients with clefts [20][21][22] or could be isolated occurrence [23][24][25] . The last-mentioned case can be either familiar or sporadic.…”

Section: Introductionmentioning

confidence: 99%

Various aspects of two treatment approaches to patients with problems of hypodontia of upper lateral incisors

et al. 2021

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Introduction. Treatment of the hypodontia of the upper lateral incisors could be orthodontic or multidisciplinary with combined orthodontic, surgical and prosthetic involvement. Both options have their pros and cons and could be quiet challenging to manage, in particularly in cases of unilateral missing of upper lateral incisor in adult patients. The aim of this case report was to described two cases with these opposite treatment approaches in the young adult patients with unilateral missing of upper lateral incisors. Case report. First case presents combined orthodontic, surgical and prosthetic treatment of the missing upper right lateral incisor in the adult patient. In 22 years, old girl clinical examination showed missing tooth 12 with almost completely closed space, midline deviation, reduced overjet and overbite and Class III molar relationship on the right side and Class I molar relationship on the left side with V shape maxillary arch and cross bite tendency in the frontal region. Based on the skeletal Class III relationship and dental findings it was decided to open the space for the tooth 12 and establish overjet and overbite and also Class I occlusion. Surgical implant insertion followed orthodontic preparation, with crown positioning after surgical healing. Second case described orthodontic treatment of unilateral hypodontia in young adult patient. In 24 years old female clinical and radiographic examination revealed hypodontia of tooth 12 with atypical tooth 22 with severe crowding in the lower arch and Class I molar relationship on the right side and half Class II relationship on the left side. Treatment decision was to extract atypical tooth 22 and tooth 35 and 44, and to move upper teeth forward to close the space. After orthodontic treatment upper canines replaced missing lateral incisors. Conclusion: Both treatments successfully resolved malocclusion and obtained good esthetical and functional results. Treatment plan and decision to open or close the space in case of hypodontia should be made individually for each patient, according to his age, malocclusion, canines shape and size and patient preferences.

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Syndromes associated with dental agenesis

Cited by 10 publications

References 58 publications

Tooth agenesis in German orthodontic patients with non-syndromic craniofacial disorder: a retrospective evaluation of panoramic radiographs

Tooth agenesis in German orthodontic patients with non-syndromic craniofacial disorder: a retrospective evaluation of panoramic radiographs

Infraocclusion level and root resorption of the primary molar in second premolar agenesis: A retrospective cross-sectional study in the Portuguese population

Various aspects of two treatment approaches to patients with problems of hypodontia of upper lateral incisors

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