Synergic antiherpetic effect of para-aminobenzoic acid and modified nucleosides

Abstract

New results of combined therapy of herpetic infection in Vero cells infected with herpes simplex type I virus resistant to acyclovir (acycloguanosine, Zovirax) are presented. Paraaminobenzoic acid stimulates antiherpetic effects of acycloguanosine, 5-(2-bronaovinyl)-2'-deoxyuridine and adenine 9-13-D-arabinofuranoside. Para-aminobenzoic acid alone is incapable of suppressing type I herpes simplex virus reproduction in cell culture. Modified nucleosides combined with it exert a higher selective antiherpetic effect. Para-aminobenzoic acid is capable of inactivating herpes viruses in culture medium.

5-Arylethynyl-2′-deoxyuridines, compounds active against HSV-1

“…The acyclovir-resistant strain of HSV-1 was isolated as described elsewhere. 15 Cytotoxicity assays. Vero cells in 96-well microtiter plates were treated with different concentrations of the experimental drugs (1.4 × 10 5 cells in 185 lL of the medium per well).…”