Synergic radiosensitization of sinomenine hydrochloride and radioiodine on human papillary thyroid carcinoma cells

Zhao, Aomei; Zhang, Jing; Liu, Yan; Jia, Xi; Lu, Xueni; Wang, Qi; Ji, Ting; Xue, Jing; Gao, Rui; Yu, Yinhua; Yang, Aimin

doi:10.1016/j.tranon.2021.101172

Cited by 4 publications

(2 citation statements)

References 48 publications

(58 reference statements)

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“…It is known to possess anti-inflammatory, immunosuppressive, antitumor, neuroprotective, antiarrhythmic and other pharmacological effects [65]. Sinomenine has been shown to inhibit proliferation of B-CPAP and TPC-1 cells, induce cell apoptosis (as-sessed by Annexin V-FITC and propidium iodide dual staining) and cell cycle arrest (in G2/M phase) [53,54].…”

Section: Alkaloids Effects On Cell Proliferation and Cell Deathmentioning

confidence: 99%

Promising Role of Alkaloids in the Prevention and Treatment of Thyroid Cancer and Autoimmune Thyroid Disease: A Comprehensive Review of the Current Evidence

Di Dalmazi,

Giuliani,

Bucci

et al. 2024

IJMS

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Thyroid cancer (TC) and thyroid autoimmune disorders (AITD) are among the most common diseases in the general population, with higher incidence in women. Chronic inflammation and autoimmunity play a pivotal role in carcinogenesis. Some studies, indeed, have pointed out the presence of AITD as a risk factor for TC, although this issue remains controversial. Prevention of autoimmune disease and cancer is the ultimate goal for clinicians and scientists, but it is not always feasible. Thus, new treatments, that overcome the current barriers to prevention and treatment of TC and AITD are needed. Alkaloids are secondary plant metabolites endowed with several biological activities including anticancer and immunomodulatory properties. In this perspective, alkaloids may represent a promising source of prophylactic and therapeutic agents for TC and AITD. This review encompasses the current published literature on alkaloids effects on TC and AITD, with a specific focus on the pathways involved in TC and AITD development and progression.

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Section: Alkaloids Effects On Cell Proliferation and Cell Deathmentioning

confidence: 99%

Promising Role of Alkaloids in the Prevention and Treatment of Thyroid Cancer and Autoimmune Thyroid Disease: A Comprehensive Review of the Current Evidence

Di Dalmazi,

Giuliani,

Bucci

et al. 2024

IJMS

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show abstract

“…In oesophageal cancer, sinomenine hydrochloride can increase radiation sensitivity in ESCC cells by inducing G2/M phase arrest, promoting radiation-induced apoptosis and inhibiting the DNA double strand break (DSB) repair pathway ( 34 ). Zhao et al suggests that sinomenine hydrochloride may be a potential sensitizer for papillary thyroid cancer after total thyroidectomy, which is related to the downregulation of Bcl-2 and Bax protein expression and the upregulation of Fas, p21, p-ATM, p-Chk 1, p-Chk 2, and p53 protein expression ( 40 ).…”

Section: Sinomenine Enhances Sensitivity To Chemotherapy or Radiother...mentioning

confidence: 99%

The anti-tumor potential of sinomenine: a narrative review

Zhu,

Gao

2023

Transl Cancer Res

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Background and Objective Currently, chemotherapy is the main treatment for most tumors. However, drug resistance and many adverse reactions associated with chemotherapy greatly limit its use. Therefore, an increasing number of researchers have shifted the research focus the anti-tumor activity of traditional Chinese medicine. The objective of this article is to review the anti-tumor mechanism of sinomenine and its derivatives to provide a reference for further study and clinical transformation. Methods In this study, we searched for relevant articles on the anti-tumor mechanism of Sinomenium using databases such as PubMed and Medline. Key Content and Findings Sinomenine is a monomer alkaloid component extracted from the rhizome of Sinomenium acuturn . A number of basic studies have proven that sinomenine and its derivatives show significant anti-tumor activity in breast cancer, lung cancer, liver cancer, stomach cancer, ovarian cancer, osteosarcoma and other tumors. They can induce apoptosis and autophagic death of tumor cells, inhibit proliferation, migration and invasion of tumor cells, increase the sensitivity of tumor cells to radiotherapy and chemotherapy, and reverse the drug resistance through various molecular mechanisms. In addition, sinomenine can effectively relieve osteolysis and bone pain in tumor patients. At present, anti-tumor research on sinomenine remains in the basic experimental stage. Conclusions Sinomenine and its derivatives are rich in substances with high anti-tumor potential. This analysis provides a review of the anti-tumor effects and mechanisms of sinomenine, with the hope of further exploring the medical value of sinomenine in anti-tumor treatments.

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Pharmacokinetics, tissue distribution, plasma protein binding rate and excretion of sinoacutine following intravenous administration in female and male Sprague-Dawley rats

Zhu¹,

Mei

Peng³

et al. 2022

Xenobiotica

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Synergic radiosensitization of sinomenine hydrochloride and radioiodine on human papillary thyroid carcinoma cells

Cited by 4 publications

References 48 publications

Promising Role of Alkaloids in the Prevention and Treatment of Thyroid Cancer and Autoimmune Thyroid Disease: A Comprehensive Review of the Current Evidence

Promising Role of Alkaloids in the Prevention and Treatment of Thyroid Cancer and Autoimmune Thyroid Disease: A Comprehensive Review of the Current Evidence

The anti-tumor potential of sinomenine: a narrative review

Pharmacokinetics, tissue distribution, plasma protein binding rate and excretion of sinoacutine following intravenous administration in female and male Sprague-Dawley rats

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