Synergism between antibiotics and plant extracts or essential oils with efflux pump inhibitory activity in coping with multidrug-resistant staphylococci

Mikulášová, Mária; Chovanová, Romana; Vaverková, Š.

doi:10.1007/s11101-016-9458-0

Cited by 45 publications

(28 citation statements)

References 79 publications

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“…Efflux pumps are the main bacterial resistance mechanism which renders tetracycline inactive. 31 A total of nine multidrug efflux systems have been identified in Acinetobacter spp. including Tet (A), a potent tetracycline efflux protein.…”

Section: Quantification Of Toxicitymentioning

confidence: 99%

The Interactive Antimicrobial Activity of Conventional Antibiotics and Petalostigma spp. Extracts Against Bacterial Triggers of some Autoimmune Inflammatory Diseases

Ilanko¹,

Cock²

2019

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Section: Quantification Of Toxicitymentioning

confidence: 99%

The Interactive Antimicrobial Activity of Conventional Antibiotics and Petalostigma spp. Extracts Against Bacterial Triggers of some Autoimmune Inflammatory Diseases

Ilanko¹,

Cock²

2019

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Section: Introductionmentioning

confidence: 99%

“…Volatiles are typically enriched in essential oils (EOs), several of which are known for their antimicrobial activity against a wide variety of microorganisms including multi-resistant strains. [7][8][9][10][11][12] Different assays are available to test the antimicrobial activity of the vapour-phase of volatiles. 5,[12][13][14][15][16] However, they mostly focus on the direct activity of the vapour-phase, and do not account for the vapour-phase-mediated Adam F. Feyaerts and Lotte Mathé contributed equally to this study.…”

Section: Introductionmentioning

confidence: 99%

Assay and recommendations for the detection of vapour‐phase‐mediated antimicrobial activities

Feyaerts

Mathé

Luyten

et al. 2017

Flavour & Fragrance J

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Antimicrobial activity assays can be carried out in aqueous solutions using multi‐well plates. However, some bioactive compounds are volatile and can cause effects at a distance. To detect such vapour‐phase‐mediated antimicrobial activity, we introduce the vapour‐phase‐mediated patch assay, a simple bioassay that uses standard microtitre plates. As a proof‐of‐principle, we use the vapour‐phase‐mediated patch assay to test a small but chemically diverse set of selected essential oils with known antifungal activities i.e. Origanum compactum, Artemisia dracunculus, Cinnamomum camphora ct linalool, Cinnamomum cassia and Melissa officinalis, as well as their corresponding major components carvacrol, estragole, linalool, trans‐cinnamaldehyde and citral, against two pathogenic Candida species. As all but one of the tested essential oils i.e. Artemisia dracunculus and its corresponding component estragole, showed vapour‐phase‐mediated antimicrobial activity, we conclude that it is a rather common characteristic of essential oils and their components, that should always be taken into consideration. Additionally, we provide suggestions to prevent false positive results due to possible vapour‐phase‐mediated antimicrobial activities in bioactivity tests.

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“…Efflux pumps are the main bacterial resistance mechanism which renders tetracycline inactive. 36 A total of nine multidrug efflux systems have been identified including Tet (A), a potent tetracycline efflux protein. 36 It is therefore possible that S. spinescens extract component(s) may be inhibiting one or more tetracycline efflux pumps, thereby blocking tetracycline efflux from the cell and allowing the antibiotic to inhibit bacterial protein synthesis.…”

Section: Varied Ratio Combination Studies (Isobolograms)mentioning

confidence: 99%

Interactive Antimicrobial and Toxicity Profiles of Scaevola spinescens R.Br. Extracts with Conventional Antibiotics

Blonk¹,

Cock²

2018

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Synergism between antibiotics and plant extracts or essential oils with efflux pump inhibitory activity in coping with multidrug-resistant staphylococci

Cited by 45 publications

References 79 publications

The Interactive Antimicrobial Activity of Conventional Antibiotics and Petalostigma spp. Extracts Against Bacterial Triggers of some Autoimmune Inflammatory Diseases

The Interactive Antimicrobial Activity of Conventional Antibiotics and Petalostigma spp. Extracts Against Bacterial Triggers of some Autoimmune Inflammatory Diseases

Assay and recommendations for the detection of vapour‐phase‐mediated antimicrobial activities

Interactive Antimicrobial and Toxicity Profiles of Scaevola spinescens R.Br. Extracts with Conventional Antibiotics

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