Synergism Effects of Ursolic Acid Supplementation on the Levels of Irisin, C-reactive Protein, IL-6, and TNF-α During High-intensity Resistance Training in Low Activity Men

Abstract

Background:: Ursolic Acid (UA) is a pentacyclic triterpenoid carboxylic acid which is extracted from plants. UA may enhance the effect of Resistance Training (RT) in human. Objective: Current research was designed to show the effect of High-Intensity Resistance Training (HIRT) in the presence or absence of UA on the serum levels of irisin, CRP, IL-6 and TNF-α in the low activity men. Method:: The study included twenty-two healthy male HIRT with placebo, supplementation, and HIRT in the presence of UA supplementation. The two groups received eight-week intervention including 2 sets of 8 exercises, with 8~10 repetitions at 70~75% of 1 repetition maximum and a 2 min rest interval between sets, performed 3 times/week. Placebo or UA orally was evaluated as 1 capsule 3 times/day during 8 weeks. The subsequent factors were measured post- and preintervention: C-Reactive Protein (CRP), Irisin, Tumor Necrotic Factor (TNF-α) and Interleukin-6 (IL-6). Results:: UA supplementation significantly increased the plasma levels of irisin in the HIRT+UA group versus the HIRT+P group (p<0.05). UA treatment also dramatically decreased the plasma levels of CRP, IL-6, and TNF-α in the HIRT+UA group versus the HIRT+P group (p<0.05). Conclusion:: The current data showed that UA-induced an increase in serum irisin and reduction of CRP, IL-6, and TNF-α may have beneficial effects as a chemical for increasing of the effects of HIRT in low activity men.

Effect of ursodeoxycholic acid therapy due to pregnant intrahepatic cholestasis on chemerin and irisin levels

“…The obtained results show that therapy with UDCA decreases the concentration of irisin. Simultaneously, it should be considered based on the data from literature, that the observed trend in the concentration changes of irisin during therapy indicates a growth in the expression of proinflammatory cytokines (Asghari et al, ; Eslampour et al, ). A second of the assessed indicators was chemerin, which for the most part is secreted by adipocytes of adipose tissue, hepatocytes, thrombocytes and nephrons.…”

“…Consequently, this would result in a change of concentration of other products both intermediate and final of the given signaling pathway such as cytokine, which would affect the concentration profile of irisin(Perakakis et al, 2017;Ye et al, 2019).The obtained results show that therapy with UDCA decreases the concentration of irisin. Simultaneously, it should be considered based on the data from literature, that the observed trend in the concentration changes of irisin during therapy indicates a growth in the expression of proinflammatory cytokines(Asghari et al, 2019;Eslampour et al, 2019). A second of the assessed indicators was chemerin, which for the most part is secreted by adipocytes of adipose tissue, hepatocytes, thrombocytes and nephrons.…”

Immunomodulatory properties of triterpenes

“…In a randomized controlled trial, ursolic acid (3 × 1 capsule, 8 weeks) supplementation combined with High-Intensity Resistance Training was administered to twenty-two healthy and low-activity male volunteers. As a result, it was determined that ursolic acid supplementation significantly reduced plasma levels of CRP, IL-6 and TNF-α compared to placebo ( p < 0.05) (Asghari et al 2020 ). In a randomized, double-blind, placebo-controlled clinical trial, 24 patients with a diagnosis of metabolic syndrome were treated with ursolic acid 150 mg daily for 12 weeks.…”