Background:: Ursolic Acid (UA) is a pentacyclic triterpenoid carboxylic acid which is extracted from plants. UA may enhance the effect of Resistance Training (RT) in human. Objective: Current research was designed to show the effect of High-Intensity Resistance Training (HIRT) in the presence or absence of UA on the serum levels of irisin, CRP, IL-6 and TNF-α in the low activity men. Method:: The study included twenty-two healthy male HIRT with placebo, supplementation, and HIRT in the presence of UA supplementation. The two groups received eight-week intervention including 2 sets of 8 exercises, with 8~10 repetitions at 70~75% of 1 repetition maximum and a 2 min rest interval between sets, performed 3 times/week. Placebo or UA orally was evaluated as 1 capsule 3 times/day during 8 weeks. The subsequent factors were measured post- and preintervention: C-Reactive Protein (CRP), Irisin, Tumor Necrotic Factor (TNF-α) and Interleukin-6 (IL-6). Results:: UA supplementation significantly increased the plasma levels of irisin in the HIRT+UA group versus the HIRT+P group (p<0.05). UA treatment also dramatically decreased the plasma levels of CRP, IL-6, and TNF-α in the HIRT+UA group versus the HIRT+P group (p<0.05). Conclusion:: The current data showed that UA-induced an increase in serum irisin and reduction of CRP, IL-6, and TNF-α may have beneficial effects as a chemical for increasing of the effects of HIRT in low activity men.

Introduction: In 2016, WHO gave a comprehensive classification system that included morphology, immunophenotyping, molecular and genetic findings. Flow cytometric immunophenotyping is the backbone of WHO classification, helping to make a more accurate and faster diagnosis. Aim: This study has been conducted to find immunophenotyping aberrancy of acute leukemia (AL) and its association with gender and age group. Material and methods: This is a descriptive retrospective study of 1012 AL patients diagnosed between January 2011 and January 2019, including all new patients of all ages and both sexes, who had available immunophenotyping data. Results and discussion: The most common aberrant antigen on acute myeloid leukemia (AML) was CD7, on precursor B lymphoblastic leukemia (B-ALL) was CD33 and on precursor T lymphoblastic leukemia (T-ALL) was CD13. There was no association between sex/age and antigen aberrancy except a significant increase in CD34 loss on pre B acute lymphoblastic leukemia (pre B-ALL) and HLA-DR expression on acute promyelocytic leukemia (APL) in males compared to female patients and an increase of CD19 expression on non-APL-AML and an elevation of CD34 loss on T-ALL in adult compared to pediatric patients. Not only detection of aberrant expression of CD markers in leukemic cells helps to estimate molecular abnormalities and has a prognostic effect, but also a specification of neoplastic cell markers at the time of diagnosis is essential for monitoring patients after treatment. Conclusions: Although in this study, no association between sex/age and aberrancy of antigens was detected (except in certain AL subtypes), AL specific immunophenotype is essential for minimal residual disease detection.

The present study aims to investigate the effects of two different loading patterns of resistance training (skewed pyramid & reverse step) on some physical and physiological capabilities of non-athlete men. For this purpose, 30 non-athlete men with a resistance training experience of less than six months are selected among volunteers and randomly assigned to control (n=10), reverse step loading (n=10), and skewed pyramid loading (n=10) groups. Their strength, speed, agility, explosive power, muscle volume, and body composition were measured before and after 10 weeks of training. Two-way ANOVA and Tukey post-hoc tests were used for statistical analysis. Results show that in both groups of skewed pyramid and reverse step, the variables of strength, speed, agility, explosive power, and muscle volume have had a significant increase compared to the control group. Also, the body composition of the training groups significantly improved and fat percentage decreased (p˂0.05). However, there were more positive changes in thigh volume, lower body strength and body fat percentage in skewed pyramid compared to reverse step (p˂0.05). Generally, it seems that the skewed pyramid pattern has a higher importance and priority than the reverse step pattern in improving both physical and physiological factors, especially muscle strength and muscle volume development of non-athlete men.

Background: Intensity resistance training and ursolic acid (UA) supplementation may be effective against metabolic disorders. Introduction: In this study, we explored the impacts of a moderate-to-high intensity resistance circuit training (MHRCT) and UA supplementation to improve these pathological changes in young older obese women (women between the ages of 50 and 70). Methods: The study included Twenty-five young older women (age > 50 years and ≤70 years) with stage I-II obesity (BMI ≥ 30 and <40 kg/m2 ), received eight weeks placebo with MHRCT, and MHRCT with UA supplementation. UA or Placebo orally was ingested as a capsule three times per day for eight weeks. The following parameters were evaluated post- and preintervention. Data were analyzed using ANOVA with repeated measures. Results: Interleukin-15 (IL-15), Interleukin-6 (IL-6), Insulin, and HOMA-IR decreased significantly in the placebo and UA groups versus control, but the UA group significantly decreased in compared with the placebo (p<0.05). In turn, the BrainDerived Neurotrophic Factor (BDNF) and Irisin levels showed an increase significant in the placebo and UA groups versus control. However, the BDNF in UA group significantly increased in compared with the placebo (p < 0.05). Conclusion: We demonstrated that applying resistance training can reverse the pathological changes that may occur with aging and sedentary life style. Our results showed that UA can enhance the effects of this type of exercise. Therefore, a combination of resistance training program and UA supplementation may be considered as a novel and influential intervention to metabolic derangements and also decrease the burden associated with this condition.