Synergism of microwave irradiation and enzyme catalysis in synthesis of isoniazid

Yadav, Ganapati D.; Sajgure, A.

doi:10.1002/jctb.1738

Cited by 41 publications

(17 citation statements)

References 23 publications

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“…When reactions were conducted in that way, yields in the range of 80% were only achieved after 48 h (49). Consequently, not only the enzyme was active under the reaction conditions, but an enhancement in the activity was achieved under microwave irradiation, consistent with literature reports (21,25,33). Remarkably, significant higher yields were observed in solvent-free conditions, compared to literature data (21).…”

Section: Resultssupporting

confidence: 90%

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Microwave-assisted solvent-free lipase catalyzed transesterification of β-ketoesters

Risso

Mazzini

Kröger

et al. 2012

Green Chemistry Letters and Reviews

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Lipase-catalyzed transesterification was used as an efficient tool for the interconversion of b-ketoesters. Catalytic activity of commercial lipase B from Candida antarctica (Novozym 435) was evaluated in systems involving non activated acyl donors, and enhanced using microwave irradiation. Interestingly, the combination of CAL B in microwave irradiation worked excellent in solvent-free conditions, thus assuring a highly competitive and environment-friendly process with high yields (up to 96%) in competitive times (B 2h). The combination of biocatalysis with solvent-free systems and microwave assistance is currently scarcely used, and may represent a powerful synergy for preparative reactions.

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Section: Resultssupporting

confidence: 90%

“…Likewise, Yadav and colleagues highlighted the synergism between lipase activity and microwave irradiation in CAL B-catalyzed transesterifications (21,25,33). Moderate-to-good conversions at short reaction times compared to conventionally heated reactions were reported.…”

Section: Research Lettermentioning

confidence: 99%

Microwave-assisted solvent-free lipase catalyzed transesterification of β-ketoesters

Risso

Mazzini

Kröger

et al. 2012

Green Chemistry Letters and Reviews

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“…In particular, microbial lipases or triacylglycerol hydrolases (E.C. 3.1.1.3) have wide industrial applications in organic synthesis as environmentally friendly catalysts (Yadav and Sajgure, 2007;Yadav et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

NANOBIOCATALYTIC SYSTEMS BASED ON LIPASE-Fe3O4 AND CONVENTIONAL SYSTEMS FOR ISONIAZID SYNTHESIS: A COMPARATIVE STUDY

Costa

Souza

Fechine

et al. 2016

Braz. J. Chem. Eng.

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-Superparamagnetic nanomaterials have attracted interest in many areas due to the high saturation magnetization and surface area. For enzyme immobilization, these properties favor the enzyme-support contact during the immobilization reaction and easy separation from the reaction mixture by use of low-cost magnetic processes. Iron oxide magnetic nanoparticles (Fe3O4, MNPs), produced by the co-precipitation method, functionalized with 3-aminopropyltriethoxysilane (APTES) and glutaraldehyde (GLU), were evaluated as a solid support for Candida antarctica lipase B (CALB) immobilization. The nanomagnetic derivative (11nm) obtained after CALB immobilization (MNPs/APTES/GLU/CALB) was evaluated as biocatalyst in isoniazide (INH) synthesis using ethyl isonicotinate (INE) and hydrazine hydrate (HID) as substrates, in 1,4-dioxane. The results showed that MNPs/APTES/CALB had a similar performance when compared to a commercial enzyme Novozym 435, showing significant advantages over other biocatalysts, such as Rhizhomucor miehei lipase (RML) and CALB immobilized on non-conventional, low-cost, chitosan-based supports.

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“…Microwave assisted enzymatic reactions or also called as Microwave Irradiation-Enzyme Coupling Catalysis (MIECC) reactions have been proven as a useful tool for many enzymatic transformations in both aqueous and organic solutions [30][31][32]. It has been proposed that in case of low power of high-frequency electromagnetic field the nonthermal activation of enzyme may be observed [33,34].…”

Section: Introductionmentioning

confidence: 99%

Microwave-Assisted Alkaline Pretreatment and Microwave Assisted Enzymatic Saccharification of Oil Palm Empty Fruit Bunch Fiber for Enhanced Fermentable Sugar Yield

Nomanbhay¹,

Hussain²,

Palanisamy³

2013

JSBS

104

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Lignocellulosic materials are promising alternative feedstocks for bioethanol production. However, the recalcitrant nature of lignocellulosic biomass necessitates an efficient pretreatment pretreatment step to improve the yield of fermentable sugars and maximizing the enzymatic hydrolysis efficiency. Microwave pretreatment may be a good alternative as it can reduce the pretreatment time and improve the enzymatic activity during hydrolysis. The overall goal of this paper is to expand the current state of knowledge on microwave-based pretreatment of lignocellulosic biomass and microwave assisted enzymatic reaction or Microwave Irradiation-Enzyme Coupling Catalysis (MIECC). In the present study, a comparison of microwave assisted alkali pretreatment was tried using Oil Palm empty fruit bunch. The microwave assisted alkali pretreatment of EFB using NaOH, significantly improved the enzymatic saccharification of EFB by removing more lignin and hemicellulose and increasing its accessibility to hydrolytic enzymes. The results showed that the optimum pretreatment condition was 3% (w/v) NaOH at 180 W for 12 minutes with the optimum component loss of lignin and holocellulose of about 74% and 24.5% respectively. The subsequent enzymatic saccharification of EFB pretreated by microwave assisted NaOH (3% w/v); resulted in 411 mg of reducing sugar per gram EFB at cellulose enzyme dosage of 20 FPU. The overall enhancement by the microwave treatment during the microwave assisted alkali pretreatment and microwave assisted enzymatic hydrolysis was 5.8 fold. The present study has highlighted the importance of well controlled microwave assisted enzymatic reaction to enhance the overall reaction rate of the process.

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Synergism of microwave irradiation and enzyme catalysis in synthesis of isoniazid

Cited by 41 publications

References 23 publications

Microwave-assisted solvent-free lipase catalyzed transesterification of β-ketoesters

Microwave-assisted solvent-free lipase catalyzed transesterification of β-ketoesters

NANOBIOCATALYTIC SYSTEMS BASED ON LIPASE-Fe3O4 AND CONVENTIONAL SYSTEMS FOR ISONIAZID SYNTHESIS: A COMPARATIVE STUDY

Microwave-Assisted Alkaline Pretreatment and Microwave Assisted Enzymatic Saccharification of Oil Palm Empty Fruit Bunch Fiber for Enhanced Fermentable Sugar Yield

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