Synergistic activity of curcumin with methotrexate in ameliorating Freund's Complete Adjuvant induced arthritis with reduced hepatotoxicity in experimental animals

A novel approach to arthritis treatment based on resveratrol and curcumin co-encapsulated in lipid-core nanocapsules: In vivo studies

“…Resveratrol decreased paw swelling, and the most marked suppressive effect was obtained with 100 mg/kg of resveratrol. Recently, an improved anti-arthritic activity with minimal toxicity was demonstrated by the combined therapy of curcumin with low doses of methotrexate (Banji et al, 2011) or prednisolone (Kuncha et al, 2014) in CFA-induced arthritis rats. In the second study, as control, the authors evaluated the anti-arthritic effects of curcumin at a dose of 10 mg/kg (i.p.)…”

Study on the interactions of trans-resveratrol and curcumin with bovine α-lactalbumin by spectroscopic analysis and molecular docking

“…This spice is responsible for the wide range of beneficial pharmacological and biological activities, including anti-inflammatory, antioxidant and anticancer effects (Yu and Huang., 2010;Banji et al, 2011). This yellowish color substance has been used in ancient times due to the wide pharmacological and medicinal activities including cancer and inflammation treatments and it is still used as food colorant because of its strong color (Selvam et al, 2005;Gardikis et al, 2006;Yu and Huang., 2010;Banji et al, 2011). The chemical structure of curcumin is shown in Figure 1a Trans-resveratrol (trans-3, 4´, 5-trihydroxystilbene) is another natural polyphenolic compound found in red wine and in several fruits and vegetables including peanuts and skin of grapes.…”

Curcumin: an orally bioavailable blocker of TNF and other pro‐inflammatory biomarkers

“…In addition, curcumin has been found to down-regulate the expression of TNF-a and IL-1b in ankle joints and decrease NF-kB activity, PGE2 production, COX-2 expression and MMP secretion in synoviocytes. Furthermore, curcumin has been shown to have a synergistic effect with methotrexate in decreasing adjuvant-induced arthritis in mice and in minimizing liver damage (Banji et al, 2011).…”