Synergistic and Antagonistic Effects of Aerosol Components on Its Oxidative Potential as Predictor of Particle Toxicity

Pietrogrande, Maria Chiara; Romanato, Luisa; Russo, Mara

doi:10.3390/toxics10040196

Cited by 14 publications

(6 citation statements)

References 64 publications

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“…In order to compare the present results with the literature data, often obtained on daily aerosol samples, we calculated the daily mean of the OP_DTT observed in Birr. The OP_DTT v values observed in Birr (from 0.08 to 1.3 nmol min −1 m −3 ) tend to be higher than those typically reported for rural locations in similar winter conditions [26,64,65]. This is not unexpected, as typically rural background sites are located far from direct aerosol sources, while in the present study, measurements were performed downtown in a town of 6000 inhabitants.…”

Section: Temporal Variability Of Opcontrasting

confidence: 47%

Important Contribution to Aerosol Oxidative Potential from Residential Solid Fuel Burning in Central Ireland

Rinaldi,

Manarini,

Lucertini

et al. 2024

Atmosphere

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Numerous studies have shown negative health effects related to exposure to ambient particulate matter (PM), likely due to induced oxidative stress. In this study, we have examined ambient PM samples from Birr, a small (~5000 inhabitants) town in central Ireland, for their water-soluble DTT-based oxidative potential (OP_DTT) with a resolution of 6 h, together with online chemical characterization measurements, to assess the OP of organic aerosols, in particular from residential solid fuel burning. The OP_DTT normalized by the volume of sampled air shows a high variability, ranging from <0.1 to 3.8 nmol min−1 m−3, and a high correlation with PM mass. A lower variability was associated with the mass-normalized OP. Nevertheless, both tended to present higher values during night-time pollution episodes. Simple and multivariate linear regression approaches linked OP_DTT to residential solid fuel burning, and in particular to wood (~87%) and peat (~13%) combustion. The results of the present study show how residential solid fuel burning can have a severe impact on air quality, even in small towns, with potential negative health effects on the exposed population.

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Section: Temporal Variability Of Opcontrasting

confidence: 47%

Important Contribution to Aerosol Oxidative Potential from Residential Solid Fuel Burning in Central Ireland

Rinaldi,

Manarini,

Lucertini

et al. 2024

Atmosphere

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“…OP zohledňuje různé velikosti PM, chemické složení PM, toxické účinky jednotlivých složek, interakce jednotlivých složek s jinými znečišťujícími látkami a je považován za relevantnější měřítko zhodnocení negativních účinků aerosolu na lidské zdraví než hmotnostní koncentrace PM nebo koncentrace jednotlivých složek PM (cit. 30 ).…”

Section: Hodnocení Toxicity Atmosférického Aerosoluunclassified

Oxidative Potential: A New Indicator of Aerosol Toxicity

Cigánková,

Mikuška

2024

Chem. Listy

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Atmospheric aerosol particles are considered to be a significant health risk worldwide. Although the exact mechanisms of aerosol toxicity are still not fully understood, several studies report that the generation of reactive oxygen species (ROS) is one of the main mechanisms responsible for chronic and acute health problems. For this reason, oxidative potential (OP) which is defined as the ability of an aerosol to generate ROS, has been proposed as a relevant parameter for assessing aerosol toxicity. This article describes different acellular in vitro methods to determine OP and the influence of chemical composition and aerosol size on OP.

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“…The differences between the seasonal behavior of OP values among different locations could be attributed to the inter site variability in the concentrations of PM redox-active species (Pietrogrande et al 2018). However, it should also be considered that synergistic and antagonistic interactions between PM components may affect OP values (Borlaza et al 2021;Pietrogrande et al 2022) and that these interactions depend on the aerosol chemical composition, which is characteristic of the monitoring site. It is interesting to point out that both the OP AA and OP DTT were more variable during winter than summer, similarly to previous studies (Calas et al 2018).…”

Section: Seasonal Variability Of the Oxidative Potentialmentioning

confidence: 99%

Sensitivity of PM10 oxidative potential to aerosol chemical composition at a Mediterranean urban site: ascorbic acid versus dithiothreitol measurements

Clemente

Gil-Moltó

Yubero

et al. 2023

Air Qual Atmos Health

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The oxidative potential (OP) of PM10 daily samples collected at a traffic site in southeastern Spain during summer and winter was assessed by two acellular assays: the ascorbic acid (AA) and dithiothreitol (DTT) methods. Although PM10 levels were similar during both periods, OP values (expressed in nmol min−1 m−3) showed a defined seasonal trend. The AA activity was higher in summer than in winter, whereas the DTT reactivity exhibited an opposite seasonal pattern. Both assays were sensitive to different PM10 components, as shown by the results of the linear correlation analysis. Moreover, the relationship between OP values and PM10 chemical species was not the same during summer and winter, indicating that particle toxicity is associated with different sources during the warm and cold seasons. When OP values were expressed on a mass basis (nmol min−1 µg−1), lower correlation coefficients with PM10 chemical species were generally obtained compared to volume-normalized activities. These outcomes suggest that only some specific components have a significant intrinsic oxidative potential.

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Synergistic and Antagonistic Effects of Aerosol Components on Its Oxidative Potential as Predictor of Particle Toxicity

Cited by 14 publications

References 64 publications

Important Contribution to Aerosol Oxidative Potential from Residential Solid Fuel Burning in Central Ireland

Important Contribution to Aerosol Oxidative Potential from Residential Solid Fuel Burning in Central Ireland

Oxidative Potential: A New Indicator of Aerosol Toxicity

Sensitivity of PM10 oxidative potential to aerosol chemical composition at a Mediterranean urban site: ascorbic acid versus dithiothreitol measurements

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