Synergistic antibacterial combination of <i>Lavandula latifolia</i> Medik. essential oil with camphor

Karaca, Nursenem; Şener, Görkem; Demırcı, Betül; Demirci, Fatih

doi:10.1515/znc-2020-0051

Cited by 31 publications

(27 citation statements)

References 30 publications

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“…On the other hand, data on Lavandula latifolia 's antibacterial activity is scarce. However, it was reported that Lavandula latifolia essential oil had strong antibacterial activity against a variety of bacterial pathogens and that this activity was significantly enhanced when coupled with camphor oil [ 40 ]. Notably, the Lavandula genus has over 39 species and approximately 400 recognized cultivars, several of which have antimicrobial activity against bacteria and fungi [ 41 ].…”

Section: Resultsmentioning

confidence: 99%

Determination of Volatile Compounds of Mentha piperita and Lavandula multifida and Investigation of Their Antibacterial, Antioxidant, and Antidiabetic Properties

Al-Mijalli

Elsharkawy

Abdallah

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Mentha piperita and Lavandula multifida are widely used in Moroccan traditional medicine for the treatment of diabetes and infectious diseases. The aims of this work were the determination of the chemical composition of Mentha piperita (MPEO) and Lavandula multifida (LMEO) essential oils and the evaluation of their antibacterial, antioxidant, and antidiabetic activities. The chemical composition was determined by GC-MS analysis. The antibacterial effects were evaluated against several bacterial strains using disc diffusion, MIC, and MBC methods. The antioxidant activity was evaluated in vitro using DPPH, H2O2, and xanthine oxidase, and the antidiabetic activity was estimated by the inhibitory effects of α-amylase, α-glucosidase, and lipase activities. GC-MS results showed that the main compounds of MPEO were menthone (29.24%), levomenthol (38.73%), and eucalyptol (6.75%). However, eucalyptol (28.11%), 2-bornanone (11.57%), endo-borneol (7.82%), and linalyl acetate (5.22%) are the major compounds of LMEO. The results exhibited important inhibitory effects against some bacterial strains with MIC = MBC = 0.39 mg/mL for MPEO against Staphylococcus aureus ATCC. However, LMEO exhibited remarkable antioxidant and antidiabetic activities compared to MPEO. Indeed, LMEO inhibited DPPH, H2O2, and xanthine oxidase with concentrations of 15.23, 21.52, and 8.89 µg/mL, respectively. Moreover, LMEO exhibited α-amylase and α-glucosidase at IC50 = 85.34 and IC50 = 59.36 µg/mL, respectively. The findings showed that both MPEO and LMEO exhibit promising biological properties. However, the application of these species or their main bioactive compounds requires further investigation.

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Section: Resultsmentioning

confidence: 99%

Determination of Volatile Compounds of Mentha piperita and Lavandula multifida and Investigation of Their Antibacterial, Antioxidant, and Antidiabetic Properties

Al-Mijalli

Elsharkawy

Abdallah

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…Relative retention indices (RRI) were used to characterize the essential oil components, either with authentic samples or by comparison with the relative retention index (RRI) of n-alkanes, with commercial GC/MS Libraries such as MassFinder 3 Library, and the in-house "Başer Library of Essential Oil Constituents". 25…”

Section: Gc-fid and Gc/ms Analysismentioning

confidence: 99%

In Vitro ACE2 and 5-LOX Enzyme Inhibition by Menthol and Three Different Mint Essential Oils

Demirci

Karadağ

Biltekin

et al. 2021

Natural Product Communications

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Mentha arvensis L., M. citrata L., and M. spicata L. (family Lamiaceae) essential oils, and their characteristic constituent, menthol, were evaluated in vitro for angiotensin converting enzyme 2 (ACE2) and 5-lipoxygenase (5-LOX) enzyme inhibitory activity. The chemical compositions of M. arvensis, M. citrata, and M. spicata essential oils were analysed both by GC-FID, and GC/MS; 82.0%, 38.1%, and 0.4% menthol were identified, respectively. M. spicata essential oil contained 88.2% carvone as its major component. The enzyme inhibitory activities of the essential oils were evaluated using a fluorometric multiplate based enzyme inhibition kit; the ACE2 inhibitions produced by M. arvensis, M. citrata, and M. spicata essential oils were 33%, 22%, and 73%, while the 5-LOX inhibitions were 84%, 79%, and 70%, respectively. In addition, menthol also showed remarkable ACE2 inhibition of 99.8%, whereas the 5-LOX inhibition was 79.9%. As a result, menthol and the three different mint essential oils may have antiviral potential applications against coronaviruses due to their ACE2 enzyme inhibition and anti-inflammatory features. However, further in vivo studies are needed to confirm the safety and efficacy.

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“…In 96-well micro-plates (Costar ® , 3599, Corning, NY, USA), 160 μL PDB and 20 μL of different concentrations of EOs were mixed with 20 μL of four different strains of prepared A. flavus spores (at the concentration of 10 6 CFU per well), and shaken overnight at 28 °C. The fungal growth was determined by measuring the absorbance at 600 nm of fungal culture in 96-well micro-plates by using a micro-plate reader (model 680, BIO-RAD Laboratories, Inc., Hercules, CA, USA) for 24 h and 48 h [ 22 ]. All assays were performed in triplicates.…”

Section: Methodsmentioning

confidence: 99%

Inhibition of Essential Oils on Growth of Aspergillus flavus and Aflatoxin B1 Production in Broth and Poultry Feed

Han

Wang

2022

Toxins

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Aflatoxin B1 (AFB1), a common contaminant in food and feed during storage, does great harm to human and animal health. Five essential oils (thymol, carvacrol, cinnamaldehyde, eugenol, and citral) were tested for their inhibition effect against Aspergillus flavus (A. flavus) in broth and feed. Cinnamaldehyde and citral were proven to be most effective against A. flavus compared to others and have a synergistic effect when used simultaneously. The broth supplemented with cinnamaldehyde and citral was inoculated with A. flavus (106 CFU/mL) by using the checkerboard method, and mold counts and AFB1 production were tested on days 0, 1, 3, and 5. Similarly, 100 g poultry feed supplemented with the mixture of cinnamaldehyde and citral at the ratio 1:1 was also inoculated with A. flavus, and the same parameters were tested on days 0, 7, 14, and 21. In poultry feed, cinnamaldehyde and citral significantly reduced mold counts and AFB1 concentrations (p < 0.05). Results showed that cinnamaldehyde and citral have a positive synergy effect and could both inhibit at least 90% the fungal growth and aflatoxin B1 production at 40 μg/mL in broth and poultry feed, and could be an alternative to control aflatoxin contamination in food and feed in future.

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Synergistic antibacterial combination of Lavandula latifolia Medik. essential oil with camphor

Cited by 31 publications

References 30 publications

Determination of Volatile Compounds of Mentha piperita and Lavandula multifida and Investigation of Their Antibacterial, Antioxidant, and Antidiabetic Properties

Determination of Volatile Compounds of Mentha piperita and Lavandula multifida and Investigation of Their Antibacterial, Antioxidant, and Antidiabetic Properties

In Vitro ACE2 and 5-LOX Enzyme Inhibition by Menthol and Three Different Mint Essential Oils

Inhibition of Essential Oils on Growth of Aspergillus flavus and Aflatoxin B1 Production in Broth and Poultry Feed

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