Synergistic antioxidant activity and anticancer effect of green tea catechin stabilized on nanoscale cyclodextrin-based metal–organic frameworks

Ke, Fei; Zhang, Mengran; Qin, Nianqiao; Zhao, Gege; Chu, Jun; Wan, Xiaochun

doi:10.1007/s10853-019-03604-7

Cited by 71 publications

(28 citation statements)

References 34 publications

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“…They concluded that catechins showed the strongest ABTS scavenging capacity and the strongest stoichiometry of Fe 3+ reduction in the FRAP assay [31]. Besides the direct antioxidant properties of catechins, they may show synergistic interaction with endogenous antioxidants and act as indirect antioxidants as well [32,33].…”

Section: Resultsmentioning

confidence: 99%

Biological and Chemical Insights of Beech (Fagus sylvatica L.) Bark: A Source of Bioactive Compounds with Functional Properties

et al. 2019

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The present study aimed, on the one hand, to improve the yield of microwave assisted extraction (MAE) of polyphenols from beech bark by using a design of experiments (DoE) approach. On the other hand, beech bark extracts (BBE) were characterized in terms of their phytochemical profile and evaluated for biological potential (antioxidant, antibacterial, antifungal, antimutagen, anti-α-glucosidase, and anti-tyrosinase). The extraction time varies with the amount of extracted total phenolic content (TPC). The microwave power favors TPC extraction but in different proportions. The optimum conditions which gave the highest TPC (76.57 mg GAE/g dry plant material) were reached when the microwave power was 300 W, extraction time was 4 min, and the solvent was an ethanol–water (50:50) mixture. The practical value of TPC after a controlled experiment was 76.49 mg GAE/g plant material. The identified compounds were vanillic acid, gallic acid, epicatechin, catechin, protocatechuic acid, chlorogenic acid, ferulic acid, and isoquercitrin. The antioxidant potential of BBEs was demonstrated by in vitro experiments. The BBEs were active against Staphylococcus aureus, Pseudomonas aeruginosa, Salmonella typhimurium, Escherichia coli, and Candida species. All extracts were antimutagenic and expressed an inhibition on α-glucosidase and tyrosinase activity. Regarding antimutagen activity, the assayed extracts may be considered to have low or no antimutagen effects.

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Section: Resultsmentioning

confidence: 99%

Biological and Chemical Insights of Beech (Fagus sylvatica L.) Bark: A Source of Bioactive Compounds with Functional Properties

et al. 2019

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“…The π-π stacks generated between the aromatic structure of Dpphen or Phen ligand and nucleobases, as well as the anionic DNA backbone to form an electrostatic attraction with the positively charged ligands (NMe 3+ ) and metals ions (In 3+ ) ( Li et al, 2016 ). Other ionized MOFs including the carboxyl-rich MOF-n family ( Yaghi et al, 1995 ), IRMOF-n family ( Eddaoudi et al, 2002 ), MIL-n family ( Dan Hardi et al, 2009 ; Naeimi and Faghihian, 2019 ), UiO-n ( Cavka et al, 2008 ; Gupta et al, 2019 ), DUT-n ( Abazari et al, 2018 ; Grunker et al, 2014 ), and imidazole-rich ZIF-n family ( Park et al, 2006 ; Sheno et al, 2019 ; Zhao et al, 2019b ), or functional groups in the ligand, such as pyridine group (-C 5 H 4 N) ( Lago et al, 2016 ), imidazolyl (-C 3 H 3 N 2 ) ( Zhao et al, 2019b ), carboxyl group (-COOH) ( Adhikari et al, 2018 ), daunosamine and amino group (-NH 2 ) ( Nezhad-Mokhtari et al, 2019 ; Xue et al, 2019 ), phenolic hydroxyl group ( Ke et al, 2019 ), might also have great potential to be adopted as a source of electrostatic interaction for nucleic acid detection owing to the protonated ligand and the charge reverses in an acidic environment. Besides, designing charged MOF is an excellent idea ( Zhao et al, 2019c ) in addition to introducing functional groups ( Ali Akbar Razavi and Morsali, 2019 ).…”

Section: Viral Nucleic Acid Detection Based On Mofmentioning

confidence: 99%

Metal-organic frameworks for virus detection

Wang

et al. 2020

Biosensors and Bioelectronics

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Virus severely endangers human life and health, and the detection of viruses is essential for the prevention and treatment of associated diseases. Metal-organic framework (MOF), a novel hybrid porous material which is bridged by the metal clusters and organic linkers, has become a promising biosensor platform for virus detection due to its outstanding properties including high surface area, adjustable pore size, easy modification, etc. However, the MOF-based sensing platforms for virus detection are rarely summarized. This review systematically divided the detection platforms into nucleic acid and immunological (antigen and antibody) detection, and the underlying sensing mechanisms were interpreted. The nucleic acid sensing was discussed based on the properties of MOF (such as metal ion, functional group, geometry structure, size, porosity, stability, etc.), revealing the relationship between the sensing performance and properties of MOF. Moreover, antibodies sensing based on the fluorescence detection and antigens sensing based on molecular imprinting or electrochemical immunoassay were highlighted. Furthermore, the remaining challenges and future development of MOF for virus detection were further discussed and proposed. This review will provide valuable references for the construction of sophisticated sensing platform for the detection of viruses, especially the 2019 coronavirus.

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“…Nanoparticles (NPs) have been used as a novel drug and gene delivery system for the targeted therapy of human cancers [28, 29]. Compared with traditional drug delivery system, NPs are more likely to accumulate in the interior of solid tumour for a longer time and encapsulate more drugs or different kinds of drugs at the same time, thus improving synergistic antitumour activity of drugs.…”

Section: Introductionmentioning

confidence: 99%

Chitosan nanoparticles loaded with aspirin and 5‐fluororacil enable synergistic antitumour activity through the modulation of NF‐κB/COX‐2 signalling pathway

Wang

Shen

Zhao

2020

IET nanobiotechnol.

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Based on the enhancement of synergistic antitumour activity to treat cancer and the correlation between inflammation and carcinogenesis, the authors designed chitosan nanoparticles for co-delivery of 5-fluororacil (5-Fu: an as anti-cancer drug) and aspirin (a non-steroidal anti-inflammatory drug) and induced synergistic antitumour activity through the modulation of the nuclear factor kappa B (NF-κB)/cyclooxygenase-2 (COX-2) signalling pathways. The results showed that aspirin at non-cytotoxic concentrations synergistically sensitised hepatocellular carcinoma cells to 5-Fu in vitro. It demonstrated that aspirin inhibited NF-κB activation and suppressed NF-κB regulated COX-2 expression and prostaglandin E2 (PGE2) synthesis. Furthermore, the proposed results clearly indicated that the combination of 5-Fu and aspirin by chitosan nanoparticles enhanced the intracellular concentration of drugs and exerted synergistic growth inhibition and apoptosis induction on hepatocellular carcinoma cells by suppressing NF-κB activation and inhibition of expression of COX-2.

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Synergistic antioxidant activity and anticancer effect of green tea catechin stabilized on nanoscale cyclodextrin-based metal–organic frameworks

Cited by 71 publications

References 34 publications

Biological and Chemical Insights of Beech (Fagus sylvatica L.) Bark: A Source of Bioactive Compounds with Functional Properties

Biological and Chemical Insights of Beech (Fagus sylvatica L.) Bark: A Source of Bioactive Compounds with Functional Properties

Metal-organic frameworks for virus detection

Chitosan nanoparticles loaded with aspirin and 5‐fluororacil enable synergistic antitumour activity through the modulation of NF‐κB/COX‐2 signalling pathway

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