Synergistic apoptotic effects of apigenin TPGS liposomes and tyroservatide: implications for effective treatment of lung cancer

Jin, Xin; Yang, Qing; Zhang, Youwen

doi:10.2147/ijn.s140096

Cited by 47 publications

(17 citation statements)

References 38 publications

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“…Apigenin has gained increasing attention due to its anti-inflammatory, antioxidant, sedative, antihypertensive and antitumor effects [5, 6]. Apigenin has also been shown to suppress cell survival of a wide variety of tumor cells, including prostate cancer, breast cancer, melanoma and leukemia cells [7–10]. Several mechanisms for its antitumor effect have been elucidated, including cell cycle arrest with dysregulation of cell cycle proteins, induction of apoptosis, inhibition of fatty acid synthesis, production of reactive oxygen species, and inactivation of survival signaling [11].…”

Section: Introductionmentioning

confidence: 99%

Apigenin inhibits growth and migration of fibroblasts by suppressing FAK signaling

Wang

Guo

Lin

et al. 2019

Aging

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The naturally occurring compound apigenin has many biological effects, including anti-inflammatory, antioxidative and anticancer effects. Although hypertrophic scar formation is a common surgical complication, there is still no good treatment for it. In the present study, we examined the effect of apigenin on hypertrophic scar. After isolating fibroblasts from human hypertrophic scars, we assess the effects of apigenin on fibroblast cell survival, apoptosis and migration. The results showed that apigenin dose-dependently inhibited the growth and migration of hypertrophic scar fibroblasts. By inhibiting FAK kinase activity and FAK phosphorylation, apigenin also inhibited activation of the FAK signaling pathway. Apigenin thus appears to inhibit the growth and migration of hypertrophic scar fibroblasts by inhibiting FAK signaling. This suggests apigenin could potentially provide a new option for the treatment of hypertrophic scars.

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Section: Introductionmentioning

confidence: 99%

Apigenin inhibits growth and migration of fibroblasts by suppressing FAK signaling

Wang

Guo

Lin

et al. 2019

Aging

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“…In addition to colorectal cancer, apigenin/tyroservatide-loaded liposomes were applied for lung cancer therapy. It was shown that these delivery systems are able to remarkably stimulate apoptosis and cell cycle arrest at the G2 phase in A549 cells (Figure 6) (Jin et al, 2017). This is due to providing targeted delivery and enhancing the accumulation of apigenin in cancer cells.…”

Section: Apigenin-loaded Nanovehiclesmentioning

confidence: 95%

Apigenin as Tumor Suppressor in Cancers: Biotherapeutic Activity, Nanodelivery, and Mechanisms With Emphasis on Pancreatic Cancer

et al. 2020

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Pancreatic cancer is the most lethal malignancy of the gastrointestinal tract. Due to its propensity for early local and distant spread, affected patients possess extremely poor prognosis. Currently applied treatments are not effective enough to eradicate all cancer cells, and minimize their migration. Besides, these treatments are associated with adverse effects on normal cells and organs. These therapies are not able to increase the overall survival rate of patients; hence, finding novel adjuvants or alternatives is so essential. Up to now, medicinal herbs were utilized for therapeutic goals. Herbal-based medicine, as traditional biotherapeutics, were employed for cancer treatment. Of them, apigenin, as a bioactive flavonoid that possesses numerous biological properties (e.g., anti-inflammatory and anti-oxidant effects), has shown substantial anticancer activity. It seems that apigenin is capable of suppressing the proliferation of cancer cells via the induction of cell cycle arrest and apoptosis. Besides, apigenin inhibits metastasis via down-regulation of matrix metalloproteinases and the Akt signaling pathway. In pancreatic cancer cells, apigenin sensitizes cells in chemotherapy, and affects molecular pathways such as the hypoxia inducible factor (HIF), vascular endothelial growth factor (VEGF), and glucose transporter-1 (GLUT-1). Herein, the biotherapeutic activity of apigenin and its mechanisms toward cancer cells are presented in the current review to shed some light on anti-tumor activity of apigenin in different cancers, with an emphasis on pancreatic cancer.

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“…Cytotoxicity data were analyzed to determine the 50% inhibitory concentration (IC 50 ) . Synergistic effects were evaluated using CompuSyn and Chou-Talalay's plot, as described previously [28].…”

Section: Cell Viability Assaymentioning

confidence: 99%

The combined administration of parthenolide and ginsenoside CK in long circulation liposomes with targeted tLyp-1 ligand induce mitochondria-mediated lung cancer apoptosis

Jin

Zhou

Zhang

et al. 2018

Artificial Cells, Nanomedicine, and Biotechnology

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2018) The combined administration of parthenolide and ginsenoside CK in long circulation liposomes with targeted tLyp-1 ligand induce mitochondria-mediated lung cancer apoptosis, Artificial Cells, Nanomedicine, and Biotechnology, 46:sup3, S931-S942, ABSTRACT Background: Combinations of natural products with low toxicities using tumor-targeting carriers may improve cancer treatment. The combined parthenolide and ginsenoside compound K (CK) within tLyp-1 liposomes, with the aim of improving the efficacy of lung cancer treatment.Results: In vitro studies in A549 human pulmonary adenocarcinoma cells demonstrated that parthenolide/CK tLyp-1 liposomes increased reactive oxygen species levels and induced mitochondrial apoptosis. It enters into cells via receptor-mediated uptake and micropinocytosis, followed by endosomal/lysosomal escape. In vivo studies illustrated that it produced a greater antitumor effect than combined administration of these compounds, with minimal toxicity. Conclusion: The findings of this study indicated that combined application of natural products in nanocarriers could offer attractive therapeutic options.

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Synergistic apoptotic effects of apigenin TPGS liposomes and tyroservatide: implications for effective treatment of lung cancer

Cited by 47 publications

References 38 publications

Apigenin inhibits growth and migration of fibroblasts by suppressing FAK signaling

Apigenin inhibits growth and migration of fibroblasts by suppressing FAK signaling

Apigenin as Tumor Suppressor in Cancers: Biotherapeutic Activity, Nanodelivery, and Mechanisms With Emphasis on Pancreatic Cancer

The combined administration of parthenolide and ginsenoside CK in long circulation liposomes with targeted tLyp-1 ligand induce mitochondria-mediated lung cancer apoptosis

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