Synergistic application of zinc and vitamin C to support memory, attention and the reduction of the risk of the neurological diseases

Gromova, О. А.; Torshin, I. Yu.; Пронин, А. В.; Kilchevsky, M A

doi:10.17116/jnevro201711771112-119

Cited by 9 publications

(3 citation statements)

References 40 publications

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“…Interestingly, we observed that zinc ion binding was common in female and male samples. Zinc ion is an endogenous neuromodulator widely found in the central nervous system (54) 54 , and its de ciency increases the risk of neurological disease(55) 55 . We may infer that zinc-related pathways are potentially related to personal traits.…”

Section: Discussionmentioning

confidence: 99%

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Evaluating the Association Between Physical Activity and Neuroticism in UK Biobank Cohort

Meng

Cheng

et al. 2021

Preprint

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Background: The association between physical activity (PA) and neuroticism has been established, but the genetic mechanism remains elusive now. Methods: In this study, 362,421 participants from UK Biobank were used to explore the associations between PA and neuroticism, using linear regression analysis. PA was measured as excess metabolic equivalent (MET)-hours per week, assessed from a combination of walking and moderate and vigorous PA. The Gene-environment-wide interaction analyses (GEWIS) was conducted by PLINK2.0 to evaluate gene×PA interacting effects on the risk of neuroticism. DAVID tool was then used to conduct gene ontology (GO) analysis of the observed PA-interacted genes. Results: We observed negative association between PA and neuroticism in total sample (b=−0.02, P=9.02×10−37), female sample (b=−0.02, P=5.74×10−28) and male sample (b=−0.02, P=6.17×10−14). GEWIS revealed multiple significant gene×PA interaction signals for neuroticism. 78 candidate genes were observed, such as ST18(rs76573348, P=6.45×10−16)，NRCAM (rs117655943, P=4.28×10-11) and RBFOX3(rs113329299, P=4.72×10-10) in total group, SYT1(rs151016298, P=1.56×10−11), S100B(rs80199493, P=8.56×10−11) and MYT1(rs111360063, P=1.53×10−10) in female group, and NOTCH3 (rs184928292, P=3.31×10-17), SLC24A2 (rs62563282, P=9.56×10-16), CSMD1(rs73177368, P=2.11×10-13) in male group. GO enrichment analysis identified 15, 11 and 38 GO terms for total, female and male samples, such as synapse assembly (Ptotal=1.37×10-2), calcium ion binding (Pfemale=3.33×10-2) and learning or memory (Pmale=1.14×10-2).Conclusion: This study suggested the influences of physical activity on neuroticism, and identified several neuroticism associated genes interacting with PA.

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Section: Discussionmentioning

confidence: 99%

“…widely found in the central nervous system (54) 54 , and its de ciency increases the risk of neurological disease(55) 55 . We may infer that zinc-related pathways are potentially related to personal traits.…”

Section: Discussionmentioning

confidence: 99%

Evaluating the Association Between Physical Activity and Neuroticism in UK Biobank Cohort

Meng

Cheng

et al. 2021

Preprint

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“…Algumas pesquisas revelam o uso de vitaminas e antioxidantes nas condições neuropsiquiátricas tendo resultados benéficos. A vitamina C, um sinergista de zinco, mantém os recursos antioxidantes do cérebro, atividade sináptica e desintoxicação em humanos (Gromova et al, 2017). Além das vitaminas, outros antioxidantes não enzimáticos são também encontrados nos alimentos in natura, como os polifenóis.…”

Section: Introductionunclassified

Antioxidante resveratrol na modulação da via da quinurenina, um metabólito do triptofano em células gliais humanas

Maccari

Visentin

Zatti

et al. 2022

RSD

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A depressão é considerada um problema de saúde pública e é uma das principais causas de incapacidade profissional ou social em todo o mundo. Antioxidantes são substâncias conhecidas por seus efeitos preventivos ou terapêuticos em várias doenças, incluindo a depressão. Esses benefícios podem ser explicados pela capacidade inerente dessas moléculas de modular as vias de sinalização celular. O objetivo deste estudo foi avaliar os efeitos neuroprotetores do resveratrol em um modelo in vitro de depressão. Estudos experimentais foram realizados com células gliais U-87 MG derivadas da linhagem do cérebro humano. Diferentes concentrações de resveratrol foram utilizadas na presença ou ausência de quinurenina, um metabólito do aminoácido triptofano necessário para a síntese de serotonina. A viabilidade celular foi avaliada determinando a capacidade das células para reduzir o composto MTT (brometo de 3- [4,5-dimetiltiazol 2-il] -2,5-difeniltetrazolina), além da avaliação morfológica celular. Para avaliar o nível de estresse oxidativo, as células gliais tratadas foram submetidas ao teste TBARS para quantificar a peroxidação lipídica. Doses de quinurenina de 100 e 200 µM foram citotóxicas, reduzindo a viabilidade das células gliais e alterando a morfologia celular. Essa redução foi acompanhada por aumento do dano oxidativo aos lipídios. O resveratrol (10 µM) se mostrou preventivo na manutenção da viabilidade das células gliais quando tratadas com quinurenina 100 µM. Os resultados poderão colaborar para o entendimento dos mecanismos envolvidos na depressão, contribuindo com o novo enfoque da capacidade dos polifenóis, compostos naturalmente encontrados na dieta, em tornarem-se agentes terapêuticos adjuvantes para o tratamento de distúrbios neuropsiquiátricos.

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Selenium and Zinc against Aβ25–35-Induced Cytotoxicity and Tau Phosphorylation in PC12 Cells and Inhibits γ-cleavage of APP

Liu

Cui

et al. 2017

Biol Trace Elem Res

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Amyloid beta (Aβ) is the main component of the amyloid plaques that accumulate in the brains of Alzheimer patients. The present study was conducted to investigate whether the combined treatment with selenium (Se) and zinc (Zn) offers more beneficial effects than that provided by either of them alone in reversing Aβ-induced neurotoxicity in PC12 cells. Cells were pretreated with 0.1 μmol/L of Se and Zn for 4 h, after treated with 10 mmol/L Aβ for 24 h. Cells were divided into control and five treated groups, and received either 10 mmol/L Aβ10 mmol/L Aβ + 0.1 μmol/L Se, 10 mmol/L Aβ + 0.1 μmol/L Zn, 10 mmol/LAβ + 0.1 μmol/L Se + 0.1 μmol/L Zn, or 0.1 μmol/L Se + 0.1 μmol/L Zn. The result showed that cell viability was decreased in MTT metabolic rate; LDH release and MDA, HO, and NO levels were increased and the GSK-3β and phosphorylated tau protein level were increased in Aβ-treated group (P < 0.05 or P < 0.01), which whole changes were attenuated by Se and Zn and Se combined Zn. In order to evaluate whether the Se and Zn have an effect on processing pathway of amyloid precursor protein (APP), we examined the activity of γ-secretase in primary cultured cortical neuron cells. ELISA analysis showed that Se and Zn could inhibit the activity of γ-secretase. Then we also investigated the effect of Se and Zn on the Aβ concentration and APP-N-terminal fragment expression from APP695 stably transfected Chinese hamster ovary (CHO) cells. APP695 stably transfected CHO cells were treated with 0.1 μmol/L Se and Zn; cells were divided into control and four treated groups, which received either 0.5 M DAPT, 0.1 μmol/L Se, 0.1 μmol/L Zn, or 0.1 μmol/L Se + 0.1 μmol/L Zn. Se and Zn could decrease Aβ production and increase the APP-N-terminal fragment protein expression. These experiments indicate that Se and Zn have a protective effect on AD pathology that a possible mechanism is inhibiting the activity of γ-secretase to decreasing Aβ production further influencing the APP processing. Altogether, our findings may provide a novel therapeutic target to treat AD sufferers.

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Synergistic application of zinc and vitamin C to support memory, attention and the reduction of the risk of the neurological diseases

Cited by 9 publications

References 40 publications

Evaluating the Association Between Physical Activity and Neuroticism in UK Biobank Cohort

Evaluating the Association Between Physical Activity and Neuroticism in UK Biobank Cohort

Antioxidante resveratrol na modulação da via da quinurenina, um metabólito do triptofano em células gliais humanas

Selenium and Zinc against Aβ25–35-Induced Cytotoxicity and Tau Phosphorylation in PC12 Cells and Inhibits γ-cleavage of APP

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