Synergistic cancer starvation therapy via mitochondria targeting cell penetrating polypeptide

Nam, Hoyeon; Kim, Yeu‐Chun

doi:10.1016/j.jiec.2021.08.030

Cited by 6 publications

(3 citation statements)

References 44 publications

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“…Thus, tumor cells can be killed by disrupting mitochondrial redox homeostasis. [180,181] Especially, most tumor cells tend to produce energy through anaerobic glycolysis rather than via respiratory metabolism even under normoxic conditions, thus cancer cells are more sensitive to glucose concentration than normal cells. [182][183][184] GOx can react with intracellular glucose and O 2 to produce H 2 O 2 and gluconic acid, cutting off the source of nutrients.…”

Section: Photodynamic Therapy and Starvation Therapymentioning

confidence: 99%

Strategic Design of Conquering Hypoxia in Tumor for Advanced Photodynamic Therapy

Zhang

Jin

et al. 2023

Adv Healthcare Materials

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Photodynamic therapy (PDT), with its advantages of high targeting, minimally invasive, and low toxicity side effects, has been widely used in the clinical therapy of various tumors, especially superficial tumors. However, the tumor microenvironment (TME) presents hypoxia due to the low oxygen (O2) supply caused by abnormal vascularization in neoplastic tissues and high O2 consumption induced by the rapid proliferation of tumor cells. The efficacy of oxygen‐consumping PDT can be hampered by a hypoxic TME. To address this problem, researchers have been developing advanced nanoplatforms and strategies to enhance the therapeutic effect of PDT in tumor treatment. This review summarizes recent advanced PDT therapeutic strategies to against the hypoxic TME, thus enhancing PDT efficacy, including increasing O2 content in TME through delivering O2 to the tumors and in situ generations of O2; decreasing the O2 consumption during PDT by design of type I photosensitizers. Moreover, recent synergistically combined therapy of PDT and other therapeutic methods such as chemotherapy, photothermal therapy, immunotherapy, and gas therapy is accounted for by addressing the challenging problems of mono PDT in hypoxic environments, including tumor resistance, proliferation, and metastasis. Finally, perspectives of the opportunities and challenges of PDT in future clinical research and translations are provided.

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Section: Photodynamic Therapy and Starvation Therapymentioning

confidence: 99%

Strategic Design of Conquering Hypoxia in Tumor for Advanced Photodynamic Therapy

Zhang

Jin

et al. 2023

Adv Healthcare Materials

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“…Abnormal tumor metabolism is an important sign of tumor occurrence and development, and some starving cell strategies have been developed and applied in clinical practice. 1,2 Traditional starvation therapy cuts off the nutrition and energy supply of the tumor by inhibiting or blocking the formation of endothelium-dependent vessels. 3−5 However, some troublesome side effects such as an increased tumor hypoxic environment, systemic toxicity, and unpredictable metabolic syndrome often occur.…”

Section: Introductionmentioning

confidence: 99%

“…Abnormal tumor metabolism is an important sign of tumor occurrence and development, and some starving cell strategies have been developed and applied in clinical practice. , Traditional starvation therapy cuts off the nutrition and energy supply of the tumor by inhibiting or blocking the formation of endothelium-dependent vessels. − However, some troublesome side effects such as an increased tumor hypoxic environment, systemic toxicity, and unpredictable metabolic syndrome often occur . Besides, accompanying the further proliferation of residual tumor cells, a vascular-like structure called vascular mimicry (VM) can be formed to make cells adapt to the extreme tumor microenvironments (TMEs) and form distant metastasis, which directly leads to the death of most cancer patients. , Although starvation therapy is often combined with chemotherapy in practical applications, chemotherapy still suffers from various drawbacks such as poor drug solubility, high systemic toxicity, low bioavailability, and easy drug resistance .…”

Section: Introductionmentioning

confidence: 99%

Gemfibrozil-Platinum(IV) Precursors for New Enhanced-Starvation and Chemotherapy In Vitro and In Vivo

Song,

Guo,

Ding

et al. 2024

J. Med. Chem.

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A brand-new enhanced starvation is put forward to trigger sensitized chemotherapy: blocking tumor-relation blood vessel formation and accelerating nutrient degradation and efflux. Following this concept, two cisplatin-like gemfibrozil-derived Pt(IV) prodrugs, GP and GPG, are synthesized. GP and GPG had nanomolar IC 50 against A2780 cells and higher selectivity against normal cells than cisplatin. Bioactivity results confirmed that GP and GPG highly accumulated in cells and induced DNA damage, G2-phase arrest, and p53 expression. Besides, they could increase ROS and MDA levels and reduce mitochondrial membrane potential and Bcl-2 expression to promote cell apoptosis. In vivo, GP showed superior antitumor activity in A2780 tumor-bearing mice with no observable tissue damage. Mechanistic studies suggested that highly selective chemotherapy could be due to the new enhanced starvation effect: blocking vasculature formation via inhibiting the CYP2C8/EETs pathway and VEGFR2, NF-κB, and COX-2 expression and cholesterol efflux and degradation acceleration via increasing ABCA1 and PPARα.

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Targeting tumor energy metabolism via simultaneous inhibition of mitochondrial respiration and glycolysis using biodegradable hydroxyapatite nanorods

Zhang

Liu

Wan

et al. 2023

Colloids and Surfaces B: Biointerfaces

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Synergistic cancer starvation therapy via mitochondria targeting cell penetrating polypeptide

Cited by 6 publications

References 44 publications

Strategic Design of Conquering Hypoxia in Tumor for Advanced Photodynamic Therapy

Strategic Design of Conquering Hypoxia in Tumor for Advanced Photodynamic Therapy

Gemfibrozil-Platinum(IV) Precursors for New Enhanced-Starvation and Chemotherapy In Vitro and In Vivo

Targeting tumor energy metabolism via simultaneous inhibition of mitochondrial respiration and glycolysis using biodegradable hydroxyapatite nanorods

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