Synergistic cell-killing by photocatalytic and plasmonic photothermal effects of Ag@TiO2 core–shell composite nanoclusters against human epithelial carcinoma (HeLa) cells

Abdulla-Al-Mamun, Md.; Kusumoto, Yoshihumi; Zannat, Tohfatul; Islam, Shariful

doi:10.1016/j.apcata.2011.03.027

Cited by 34 publications

(21 citation statements)

References 46 publications

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“…The conjugation of NPs of a precious metal with TiO 2 NPs increases the catalytic activity of this oxide, a phenomenon confirmed in the studies of Abdulla-al-Mamun et al [102]. They reported that Ag/TiO 2 nanocomposite showed an 80% higher effectiveness in eradication of human HeLa cells than TiO 2 NPs.…”

Section: Reviewmentioning

confidence: 56%

“…Cyto- and genotoxicity of TiO 2 NPs, as well as of ZnO NPs have been proved in vitro also with many other cells, both healthy, e.g., human dermal fibroblasts [94, 95], human periodontal ligament fibroblasts [96], human alveolar macrophages [97], human gastric epithelial cells [98]; and malignant, e.g., human colonic mucinous adenocarcinoma cells (Ls-174-t line) [99], human colon adenocarcinoma cells (LoVo line) [100, 101], human cervical carcinoma cells (HeLa line) [102–105], human breast adenocarcinoma cells (MDA-MB-468 line) [106], human hepatocellular carcinoma cells (Bel 7402 line) [107], human brain glioblastoma cells (T98G line) [108, 109], or human bladder carcinoma cells (T-24 line) [110]. …”

Section: Reviewmentioning

confidence: 99%

“…Nanocomposites, e.g., gold-doped TiO 2 (Au/TiO 2 ) [101], silver-doped TiO 2 (Ag/TiO 2 ) [102], platinum-doped TiO 2 (Pt/TiO 2 ) [188], or silver-doped ZnO (Ag/ZnO) [189] are compounds increasingly often applied in anticancer therapy. The conjugation of NPs of a precious metal with TiO 2 NPs increases the catalytic activity of this oxide, a phenomenon confirmed in the studies of Abdulla-al-Mamun et al [102].…”

Section: Reviewmentioning

confidence: 99%

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Nanoparticles of Titanium and Zinc Oxides as Novel Agents in Tumor Treatment: a Review

2017

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Cancer has become a global problem. On all continents, a great number of people are diagnosed with this disease. In spite of the progress in medical care, cancer still ends fatal for a great number of the ill, either as a result of a late diagnosis or due to inefficiency of therapies. The majority of the tumors are resistant to drugs. Thus, the search for new, more effective therapy methods continues. Recently, nanotechnology has been attributed with big expectations in respect of the cancer fight. That interdisciplinary field of science creates nanomaterials (NMs) and nanoparticles (NPs) that can be applied, e.g., in nanomedicine. NMs and NPs are perceived as very promising in cancer therapy since they can perform as drug carriers, as well as photo- or sonosensitizers (compounds that generate the formation of reactive oxygen species as a result of either electromagnetic radiation excitation with an adequate wavelength or ultrasound activation, respectively). Consequently, two new treatment modalities, the photodynamic therapy (PDT) and the sonodynamic therapy (SDT) have been created. The attachment of ligands or antibodies to NMs or to NPs improve their selective distribution into the targeted organ or cell; hence, the therapy effectiveness can be improved. An important advantage of the targeted tumor treatment is lowering the cyto- and genotoxicity of active substance towards healthy cells. Therefore, both PDT and SDT constitute a valuable alternative to chemo- or radiotherapy. The vital role in cancer eradication is attributed to two inorganic sensitizers in their nanosized scale: titanium dioxide and zinc oxide.

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Section: Reviewmentioning

confidence: 56%

Section: Reviewmentioning

confidence: 99%

Section: Reviewmentioning

confidence: 99%

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Nanoparticles of Titanium and Zinc Oxides as Novel Agents in Tumor Treatment: a Review

2017

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“…Moreover, thermal excitation and photoexcitation of TiO 2 by sonoluminescence, resulting from bubbles implosion, also can lead to the formation of OH radicals [111]. Furthermore, TiO 2 conjugation with noble metals can strongly increase the catalytic activity of the material [112]. Important therapeutical improvements are obtained with TiO 2 NPs' functionalization with targeting molecules (such as folic acid [113], avidin [114] or pre S1/S2, part of the L protein from the hepatites virus [115]).…”

Section: G Canavese Et Almentioning

confidence: 99%

Nanoparticle-assisted ultrasound: A special focus on sonodynamic therapy against cancer

Canavese

Ancona

Racca

et al. 2018

Chemical Engineering Journal

353

247

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• Ultrasound-based therapies are opening new horizons in the oncological field.• Innovative and promising solutions derive from different nanoparticles-assisted ultrasound treatments.• Sonodynamic therapy (SDT) emerged recently as a novel approach for cancer treatment.• Different and complex cell death mechanisms are involved in nanoparticles-assisted SDT.• Nanoparticles-assisted ultrasound is still at its infancy in clinics. A R T I C L E I N F O Keywords:Inertial cavitation Reactive oxygen species Sonoluminescence Sonodynamic Tumor Therapy Cytotoxicity A B S T R A C TAt present, ultrasound radiation is broadly employed in medicine for both diagnostic and therapeutic purposes at various frequencies and intensities. In this review article, we focus on therapeutically-active nanoparticles (NPs) when stimulated by ultrasound. We first introduce the different ultrasound-based therapies with special attention to the techniques involved in the oncological field, then we summarize the different NPs used, ranging from soft materials, like liposomes or micro/nano-bubbles, to metal and metal oxide NPs. We therefore focus on the sonodynamic therapy and on the possible working mechanisms under debate of NPs-assisted sonodynamic treatments. We support the idea that various, complex and synergistics physical-chemical processes take place during acoustic cavitation and NP activation. Different mechanisms are therefore responsible for the final cancer cell death and strongly depends not only on the type and structure of NPs or nanocarriers, but also on the way they interact with the ultrasonic pressure waves. We conclude with a brief overview of the clinical applications of the various ultrasound therapies and the related use of NPs-assisted ultrasound in clinics, showing that this very innovative and promising approach is however still at its infancy in the clinical cancer treatment.

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“…Since the conception of plasmonic photocatalysis was proposed [69,70] , plasmonic metal/semiconductor nanostructures, characterized by their strong interaction with resonant photons through an excitation of localized surface plasmon resonance (LSPR), have received signifi cant attention in the fi elds of photocatalytic pollutant degradation [71 -74] , selective reduction and oxidation [75 -79] , cell killing [80] , as well as water splitting [81,82] . It has been demonstrated that plasmonic metal/ semiconductor nanostructures always achieved signifi cantly higher rates in various photocatalytic reactions compared to their pure semiconductor counterparts, due to the plasmonic Brought to you by | MIT Libraries Authenticated Download Date | 5/13/18 9:51 AM effects of noble metal nanoparticles, which could give rise to enhancement in light absorption and charge separation [82] .…”

Section: Plasmonic Metal/semiconductor Nanostructuresmentioning

confidence: 99%

Nanostructure designs for effective solar-to-hydrogen conversion

Shen

Mao

2012

Nanophotonics

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Conversion of energy from photons in sunlight to hydrogen through solar splitting of water is an important technology. The rising signifi cance of producing hydrogen from solar light via water splitting has motivated a surge of developing semiconductor solar-active nanostructures as photocatalysts and photoelectrodes. Traditional strategies have been developed to enhance solar light absorption (e.g., ion doping, solid solution, narrow-band-gap semiconductor or dye sensitization) and improve charge separation/transport to prompt surface reaction kinetics (e.g., semiconductor combination, co-catalyst loading, nanostructure design) for better utilizing solar energy. However, the solar-to-hydrogen effi ciency is still limited. This article provides an overview of recently demonstrated novel concepts of nanostructure designs for efficient solar hydrogen conversion, which include surface engineering, novel nanostructured heterojunctions, and photonic crystals. Those fi rst results outlined in the main text encouragingly point out the prominence and promise of these new concepts principled for designing high-effi ciency electronic and photonic nanostructures that could serve for sustainable solar hydrogen production.

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Synergistic cell-killing by photocatalytic and plasmonic photothermal effects of Ag@TiO2 core–shell composite nanoclusters against human epithelial carcinoma (HeLa) cells

Cited by 34 publications

References 46 publications

Nanoparticles of Titanium and Zinc Oxides as Novel Agents in Tumor Treatment: a Review

Nanoparticles of Titanium and Zinc Oxides as Novel Agents in Tumor Treatment: a Review

Nanoparticle-assisted ultrasound: A special focus on sonodynamic therapy against cancer

Nanostructure designs for effective solar-to-hydrogen conversion

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