Synergistic chemo-photo anticancer therapy by using reversible Diels–Alder dynamic covalent bond mediated polyprodrug amphiphiles and immunoactivation investigation

Yan, Jinhao; Jiang, Wenlong; Kang, Guijie; Li, Qingjie; Liu, Tao; Wang, Xuefu; Yin, Jun

doi:10.1039/d3bm00889d

Cited by 6 publications

(1 citation statement)

References 70 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thermo-and reduction-responsive copolymers CPT Self-assembly GSH could trigger the release of CPT drugs and was promoted by NIR light-induced photothermal therapy. [189] pH/Reduction dual-responsive HA prodrug…”

Section: Redox-responsive Polymersmentioning

confidence: 99%

Polymer-Based Drug Delivery Systems for Cancer Therapeutics

Ding,

Agrawal,

Singh

et al. 2024

Polymers

View full text Add to dashboard Cite

Chemotherapy together with surgery and/or radiotherapy are the most common therapeutic methods for treating cancer. However, the off-target effects of chemotherapy are known to produce side effects and dose-limiting toxicities. Novel delivery platforms based on natural and synthetic polymers with enhanced pharmacokinetic and therapeutic potential for the treatment of cancer have grown tremendously over the past 10 years. Polymers can facilitate selective targeting, enhance and prolong circulation, improve delivery, and provide the controlled release of cargos through various mechanisms, including physical adsorption, chemical conjugation, and/or internal loading. Notably, polymers that are biodegradable, biocompatible, and physicochemically stable are considered to be ideal delivery carriers. This biomimetic and bio-inspired system offers a bright future for effective drug delivery with the potential to overcome the obstacles encountered. This review focuses on the barriers that impact the success of chemotherapy drug delivery as well as the recent developments based on natural and synthetic polymers as platforms for improving drug delivery for treating cancer.

show abstract

Section: Redox-responsive Polymersmentioning

confidence: 99%

Polymer-Based Drug Delivery Systems for Cancer Therapeutics

Ding,

Agrawal,

Singh

et al. 2024

Polymers

View full text Add to dashboard Cite

show abstract

Polymorphic Supramolecular Therapeutic Platforms with Precise Dye/Drug Ratio to Perform Synergistic Chemo‐Photo Anti‐Tumor Therapy and Long‐Term Immune Protection

Yan,

Wang,

Zhao

et al. 2024

Adv Healthcare Materials

View full text Add to dashboard Cite

Malignant tumor has become one of the hellish killers threatening the health of people around the world, its diagnosis and treatment has become the concerns of public. However, the optimal therapeutic dose, undesired side‐effect, and long‐term immune activation were key and bottleneck problems in tumor treatment. Herein, different batches of supramolecular therapeutic platforms, including vesicles, spherical nanoparticles, and cylindrical nanorods, with precise ratios of dye to drug (1:2) and multiple stimulus responsiveness were constructed by host‐guest complexation between cyanine‐camptothecin conjugates (IR780‐CPT2) and β‐cyclodextrin (β‐CD) pendent hydrophilic copolymers. The reduction responsiveness, near‐infrared photothermal conversion and singlet oxygen (1O2) generation performances endowed these platforms excellent cancer cells killing effect in both of in vitro cellular experiments and in vivo mice models. More importantly, without affecting the weight of mice, the maturation of dendritic cells, proliferation of T cells, up‐regulation of high mobility group protein B1, and reduction of immunosuppressive regulatory T cells were detected after employing a synergistic chemo‐photo therapy, demonstrating the body's immune effect was successfully activated. Thus, during the treatment of primary tumor, the distal tumor was also inhibited. We believe this work could provide a distinctive way to fabricate supramolecular theranostic platforms with different morphologies and improve antitumor and antimetastasis capabilities.

show abstract

Applications of Diels–Alder Chemistry in Biomaterials and Drug Delivery

Yeingst,

Helton,

Hayes

2024

Macromolecular Bioscience

View full text Add to dashboard Cite

Recent studies, leveraging click chemistry reactions, have significantly advanced the fields of biomaterials and drug delivery. Of these click reactions, the Diels–Alder cycloaddition is exceptionally valuable for synthetic organic chemistry and biomaterial design, as it occurs under mild reaction conditions and can undergo a retrograde reaction, under physiologically relevant conditions, to yield the initial reactants. In this review, potential applications of the Diels–Alder reaction are explored within the nexus of biomaterials and drug delivery. This includes an emphasis on key platforms such as polymers, nanoparticles, and hydrogels which utilize Diels–Alder for drug delivery, functionalized surfaces, bioconjugation, and other diverse applications. Specifically, this review will focus on the use of Diels–Alder biomaterials in applications of tissue engineering and cancer therapies, while providing a discussion of the advantages, platforms, and applications of Diels–Alder click chemistry.

show abstract

Synergistic chemo-photo anticancer therapy by using reversible Diels–Alder dynamic covalent bond mediated polyprodrug amphiphiles and immunoactivation investigation

Abstract: Highly efficient endocytosis and multi-approach integrated therapeutic tactics are important factors in oncotherapy. With the aid of thermal reversible furan-maleimide dynamic covalent bonds and “polyprodrug amphiphiles” concept, thermal- and reduction-responsive...

Cited by 6 publications

References 70 publications

Polymer-Based Drug Delivery Systems for Cancer Therapeutics

Polymer-Based Drug Delivery Systems for Cancer Therapeutics

Polymorphic Supramolecular Therapeutic Platforms with Precise Dye/Drug Ratio to Perform Synergistic Chemo‐Photo Anti‐Tumor Therapy and Long‐Term Immune Protection

Applications of Diels–Alder Chemistry in Biomaterials and Drug Delivery

Contact Info

Product

Resources

About