Synergistic chemo-photothermal cancer therapy of pH-responsive polymeric nanoparticles loaded IR825 and DTX with charge-reversal property

Wang, Xiaowei; Gu, Yaxuan; Qi, Li; Xu, Yapeng; Shi, Yifan; Wang, Zheran; Xia, Mingyu; Li, Ji; Wang, Dongkai

doi:10.1016/j.colsurfb.2021.112164

Cited by 19 publications

(12 citation statements)

References 28 publications

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“…[101] In this section, we will present two separate therapeutic strategies. Hydrazone DOXDT [86] Hydrazone (LA)-Lys-9R [87] Hydrazone GA-PEG-HZ-PLA [88] Imino bonds A-HA-CDDP [89] Imino bonds HA-mPEG 2k -DOX [90] Imino bonds DOX-P 1 NPs [91] Low-pH Vinyl-ether bonds RBP [92] Surface charge reversal Poly(2-(diisopro-pylamino) ethyl methacrylate) PEG-CMCS-SS-PDPA/DOX [84] TAT Peptide chain PGlu-PEG/TAT-NPs [85] Poly (ethylene imine)-poly (epsilon-caprolactone) MPPD@IR825/DTX NPs [93] Micellization demicellization Poly-(ethylene glycol) methyl ether methacrylate CCDO/DOX [94] Poly (ethylene glycol)-poly (beta-amino ester) DOX-AP-pH-PMs [95] Histidine DOX/His-HA-DA [96]…”

Section: Enzymes-responsive Strategymentioning

confidence: 99%

Tumor Therapy Strategies Based on Microenvironment‐Specific Responsive Nanomaterials

Zhang

Ding

Sun

et al. 2023

Adv Healthcare Materials

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The tumor microenvironment (TME) is a complex and variable region characterized by hypoxia, low pH, high redox status, overexpression of enzymes, and high‐adenosine triphosphate concentrations. In recent years, with the continuous in‐depth study of nanomaterials, more and more TME‐specific response nanomaterials are used for tumor treatment. However, the complexity of the TME causes different types of responses with various strategies and mechanisms of action. Aiming to systematically demonstrate the recent advances in research on TME‐responsive nanomaterials, this work summarizes the characteristics of TME and outlines the strategies of different TME responses. Representative reaction types are illustrated and their merits and demerits are analyzed. Finally, forward‐looking views on TME‐response strategies for nanomaterials are presented. It is envisaged that such emerging strategies for the treatment of cancer are expected to exhibit dramatic trans‐clinical capabilities, demonstrating the extensive potential for the diagnosis and therapy of cancer.

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Section: Enzymes-responsive Strategymentioning

confidence: 99%

Tumor Therapy Strategies Based on Microenvironment‐Specific Responsive Nanomaterials

Zhang

Ding

Sun

et al. 2023

Adv Healthcare Materials

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“…Wang et al. 73 prepared MPPD@IR825 nanoparticles based on poly (ethylene imine)‐poly(ε‐caprolactone) block polymers (PEI–PCL). The dimethyl maleic anhydride‐modified PEGylated shell could increase the drug release of DOX and IR825; these nanoparticles exhibited efficient breast tumor ablation with chemo‐PTT.…”

Section: Backbones and Structures Of Multifunctional Nanoparticlesmentioning

confidence: 99%

“…Moreover, PEI can be self‐assembled with other polymeric nanoparticles to form block polymers, such as PEI–PCL. Wang et al 73 . prepared MPPD@IR825 nanoparticles based on poly (ethylene imine)‐poly(ε‐caprolactone) block polymers (PEI–PCL).…”

Section: Backbones and Structures Of Multifunctional Nanoparticlesmentioning

confidence: 99%

Multifunctional nanoparticle for cancer therapy

Wang

Zhang

Duan

et al. 2023

MedComm

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Cancer is a complex disease associated with a combination of abnormal physiological process and exhibiting dysfunctions in multiple systems. To provide effective treatment and diagnosis for cancer, current treatment strategies simultaneously focus on various tumor targets. Based on the rapid development of nanotechnology, nanocarriers have been shown to exhibit excellent potential for cancer therapy. Compared with nanoparticles with single functions, multifunctional nanoparticles are believed to be more aggressive and potent in the context of tumor targeting. However, the development of multifunctional nanoparticles is not simply an upgraded version of the original function, but involves a sophisticated system with a proper backbone, optimized modification sites, simple preparation method, and efficient function integration. Despite this, many well‐designed multifunctional nanoparticles with promising therapeutic potential have emerged recently. Here, to give a detailed understanding and analyzation of the currently developed multifunctional nanoparticles, their platform structures with organic or inorganic backbones were systemically generalized. We emphasized on the functionalization and modification strategies, which provide additional functions to the nanoparticle. We also discussed the application combination strategies that were involved in the development of nanoformulations with functional crosstalk. This review thus provides an overview of the construction strategies and application advances of multifunctional nanoparticles.

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“…However, due to the thermal expansion of PTT, chemotherapeutic drugs can be more evenly distributed in tumor tissues, enhance heterogeneity, and inhibit tumor drug resistance and metastasis. Wang et al ( 274 ) prepared an intelligent polymer-drug vehicle (MPPD@IR825/DTX) for chemo-photothermal combination therapy, which used poly(ethyleneimine)-poly (ϵ-caprolactone) block polymers as the core and dimethylmaleic anhydride-modified PEG as the shell, encapsulating docetaxel (DTX) and IR825. Compared with the free drug, IR825, MPPD@IR825/DTX nanoparticles exhibited higher temperatures under 808-nm NIR laser irradiation, which increased cytotoxicity and promoted apoptosis of tumor cells more effectively.…”

Section: Multimodal Therapy For Tumors Based On Photothermal Nanomate...mentioning

confidence: 99%

Research Progress of Photothermal Nanomaterials in Multimodal Tumor Therapy

et al. 2022

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The aggressive growth of cancer cells brings extreme challenges to cancer therapy while triggering the exploration of the application of multimodal therapy methods. Multimodal tumor therapy based on photothermal nanomaterials is a new technology to realize tumor cell thermal ablation through near-infrared light irradiation with a specific wavelength, which has the advantages of high efficiency, less adverse reactions, and effective inhibition of tumor metastasis compared with traditional treatment methods such as surgical resection, chemotherapy, and radiotherapy. Photothermal nanomaterials have gained increasing interest due to their potential applications, remarkable properties, and advantages for tumor therapy. In this review, recent advances and the common applications of photothermal nanomaterials in multimodal tumor therapy are summarized, with a focus on the different types of photothermal nanomaterials and their application in multimodal tumor therapy. Moreover, the challenges and future applications have also been speculated.

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Synergistic chemo-photothermal cancer therapy of pH-responsive polymeric nanoparticles loaded IR825 and DTX with charge-reversal property

Cited by 19 publications

References 28 publications

Tumor Therapy Strategies Based on Microenvironment‐Specific Responsive Nanomaterials

Tumor Therapy Strategies Based on Microenvironment‐Specific Responsive Nanomaterials

Multifunctional nanoparticle for cancer therapy

Research Progress of Photothermal Nanomaterials in Multimodal Tumor Therapy

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