Synergistic effect of aluminum and ionizing radiation upon ultrastructure, oxidative stress and apoptotic alterations in Paneth cells of rat intestine

Eltahawy, Noaman A.; El-Sonbaty, Sawsan M; Abunour, S.; Zahran, Walid E.

doi:10.1007/s11356-017-8392-z

Cited by 16 publications

(7 citation statements)

References 62 publications

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“…[ 16 ] In addition, electron micrograph exhibited that Al induced the injuries of epithelial cells, abnormal crypt, and increased bacterial invasions in small intestine. [ 17 ] In the present study, firstly, the morphological influence of Al was investigated in intestinal mucosa of mice. Our results showed that Al exposure induced abnormal intestinal barrier histological changes, including crypt abscesses, hyperplasia, and villous shorter, as well as inflammatory cell infiltration.…”

Section: Discussionmentioning

confidence: 99%

Resveratrol alleviates aluminum‐induced intestinal barrier dysfunction in mice

Hao

Zhu

Liu

et al. 2022

Environmental Toxicology

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Background: Aluminum is mainly exposed to the general population through food and water, and is absorbed into the systemic circulation through intestine, which in turn damages the intestinal barrier. Methods:The mice model of subchronic exposure to aluminum chloride (AlCl 3 ) was established via oral. Tail suspension test was used to detect depressive behavior. H&E staining was performed to assess pathological intestinal injury. Intestinal permeability was estimated by exogenous Evans blue content. The level of inflammatory cytokines and tight junction protein were assessed via ELISA and western blotting. Simultaneously, resveratrol (Rsv, an agonist of Sirt1) was evaluated the protective role against intestinal barrier injuries caused by aluminum exposure. Results: Our results showed that AlCl 3 induced depressive-like behavior, intestinal pathological damage and intestinal barrier permeability, resulting in intestinal barrier dysfunction. Besides, aluminum induced the expression of inflammatory cytokines, which further triggered IRF8-MMP9-mediated downregulation of tight junction proteins including CLD1, OCLD and ZO-1. After Rsv treatment, SIRT1 expression was increased, depressive symptom was improved, pathological injury was reduced, inflammatory reaction was alleviated, and intestinal barrier function restored. Conclusion: Our findings revealed that aluminum exposure induced intestinal barrier dysfunction by IRF8-MMP9 signaling pathway. Rsv alleviated these injuries via activating SIRT1.

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Section: Discussionmentioning

confidence: 99%

Resveratrol alleviates aluminum‐induced intestinal barrier dysfunction in mice

Hao

Zhu

Liu

et al. 2022

Environmental Toxicology

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“…Furthermore, it must be noted that this preliminary study presented here, lacks an exploration of other important factors that mediate radiation enteritis, such as the destruction of the intestinal epithelial barrier and tight junction after irradiation exposure [12,44]. Besides, irradiation exposure not only acts as a proinflammatory signal [5,45], but also mediates oxidative and nitrative stress to induce the production of ROS and NOS in the small intestine [7,9,46,47]. In addition, GL has been reported to possess anti-oxidant properties in a recent study [48].…”

Section: Discussionmentioning

confidence: 95%

Glycyrrhizin Ameliorates Radiation Enteritis in Mice Accompanied by the Regulation of the HMGB1/TLR4 Pathway

Zhang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Radiation enteritis is a common side effect of radiotherapy for abdominal and pelvic malignancies, which can lead to a decrease in patients’ tolerance to radiotherapy and the quality of life. It has been demonstrated that glycyrrhizin (GL) possesses significant anti-inflammatory activity. However, little is known about its anti-inflammatory effect in radiation enteritis. In the present study, we aimed to investigate the potential anti-inflammatory effects of GL on radiation enteritis and elucidate the possible underlying molecular mechanisms involved. The C57BL/6 mice were subjected to 6.5 Gy abdominal X-ray irradiation to establish a model of radiation enteritis. Hematoxylin and eosin staining was performed to analyze the pathological changes in the jejunum. The expression of TNF-α in the jejunum was analyzed by immunochemistry. The levels of inflammatory cytokines, such as TNF-α, IL-6, IL-1β, and HMGB1 in the serum were determined by enzyme-linked immunosorbent assay. The intestinal absorption capacity was tested using the D-xylose absorption assay. The levels of HMGB1 and TLR4 were analyzed by western blotting and immunofluorescence staining. We found that GL significantly alleviated the intestinal damage and reduced the levels of inflammatory cytokines, such as TNF-α, IL-6, IL-1β, and HMGB1 levels. Furthermore, the HMGB1/TLR4 signaling pathway was significantly downregulated by GL treatment. In conclusion, these findings indicate that GL has a protective effect against radiation enteritis through the inhibition of the intestinal damage and the inflammatory responses, as well as the HMGB1/TLR4 signaling pathway. Thereby, GL might be a potential therapeutic agent for the treatment of radiation enteritis.

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“…Reactive oxygen species represent a risk factor for the development of CRC, as they cause oxidative damage to the intestinal mucosa cells, leading to the breakdown of the intestinal barrier and its dysfunction. Oxidative damage leads to abnormal Paneth cell morphology, the dilatation of the crypt lumen and erosion of its villi, and an increase in the apoptosis of crypt cells and homogeneously electron-lucent granules [ 150 , 151 ], which creates an entry gate for pathogenic microorganisms. The disruption of the barrier triggers the invasion of commensal and pathogenic microorganisms and leads to contact between intestinal epithelial cells and components of the microbiota, which may have protumorigenic properties [ 10 ].…”

Section: Colorectal Carcinoma As a Multilevel Cancer Diseasementioning

confidence: 99%

Oxidative Stress, Inflammation and Colorectal Cancer: An Overview

2023

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Colorectal cancer (CRC) represents the second leading cause of cancer-related deaths worldwide. The pathogenesis of CRC is a complex multistep process. Among other factors, inflammation and oxidative stress (OS) have been reported to be involved in the initiation and development of CRC. Although OS plays a vital part in the life of all organisms, its long-term effects on the human body may be involved in the development of different chronic diseases, including cancer diseases. Chronic OS can lead to the oxidation of biomolecules (nucleic acids, lipids and proteins) or the activation of inflammatory signaling pathways, resulting in the activation of several transcription factors or the dysregulation of gene and protein expression followed by tumor initiation or cancer cell survival. In addition, it is well known that chronic intestinal diseases such as inflammatory bowel disease (IBD) are associated with an increased risk of cancer, and a link between OS and IBD initiation and progression has been reported. This review focuses on the role of oxidative stress as a causative agent of inflammation in colorectal cancer.

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Synergistic effect of aluminum and ionizing radiation upon ultrastructure, oxidative stress and apoptotic alterations in Paneth cells of rat intestine

Cited by 16 publications

References 62 publications

Resveratrol alleviates aluminum‐induced intestinal barrier dysfunction in mice

Resveratrol alleviates aluminum‐induced intestinal barrier dysfunction in mice

Glycyrrhizin Ameliorates Radiation Enteritis in Mice Accompanied by the Regulation of the HMGB1/TLR4 Pathway

Oxidative Stress, Inflammation and Colorectal Cancer: An Overview

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