Synergistic effect of dietary selenium nanoparticles and riboflavin on the enhanced thermal efficiency of fish against multiple stress factors

Kumar, Neeraj; Brahmchari, Rajive Kumar; Bhushan, Shashi; Thorat, Supriya Tukaram; Kumar, P Ramesh; Chandan, Nitish Kumar; Kumar, Mukesh; Singh, Narendra Pratap

doi:10.1016/j.jtherbio.2019.102417

Cited by 24 publications

(12 citation statements)

References 59 publications

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“…Food crops that are commonly biofortified include cereals [29], leafy vegetables like spinach [30] and lettuce [31], and fruits like strawberry [24,32,33] and pomegranate [23]. Due to their lower toxicity, strong capacity to scavenge free radicals, higher bioavailability, and stimulation effect, Se-NPs have been recently used in the production of plants [23,24,[34][35][36], fish [37][38][39][40], livestock [41], and poultry [42][43][44][45][46][47][48].…”

Section: Introductionmentioning

confidence: 99%

Selenium and Nano-Selenium Biofortification for Human Health: Opportunities and Challenges

et al. 2020

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Selenium is an essential micronutrient required for the health of humans and lower plants, but its importance for higher plants is still being investigated. The biological functions of Se related to human health revolve around its presence in 25 known selenoproteins (e.g., selenocysteine or the 21st amino acid). Humans may receive their required Se through plant uptake of soil Se, foods enriched in Se, or Se dietary supplements. Selenium nanoparticles (Se-NPs) have been applied to biofortified foods and feeds. Due to low toxicity and high efficiency, Se-NPs are used in applications such as cancer therapy and nano-medicines. Selenium and nano-selenium may be able to support and enhance the productivity of cultivated plants and animals under stressful conditions because they are antimicrobial and anti-carcinogenic agents, with antioxidant capacity and immune-modulatory efficacy. Thus, nano-selenium could be inserted in the feeds of fish and livestock to improvise stress resilience and productivity. This review offers new insights in Se and Se-NPs biofortification for edible plants and farm animals under stressful environments. Further, extensive research on Se-NPs is required to identify possible adverse effects on humans and their cytotoxicity.

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Section: Introductionmentioning

confidence: 99%

Selenium and Nano-Selenium Biofortification for Human Health: Opportunities and Challenges

et al. 2020

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“…After that, supernatant was mixed with 2 M sodium selenite (200 ml) on a shaker for 96 h. The final solution was centrifuged at 6000 rpm at 15 min at 4 °C and then pellet was obtained. The pellet was isolated and dried for 5 h. Before diet preparation, Se-NPs were crushed in to a fine powder 35 , 36 . Se-NPs were characterized through a spectrophotometer in an absorption spectrum at 360–380 nm.…”

Section: Methodsmentioning

confidence: 99%

Mitigating multiple stresses in Pangasianodon hypophthalmus with a novel dietary mixture of selenium nanoparticles and Omega-3-fatty acid

Kumar

Singh

Bhushan

et al. 2021

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Effects of a novel dietary mixture of selenium nanoparticles (Se-NPs) and omega-3-fatty acids i.e., Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on mitigating arsenic pollution, high-temperature stress and bacterial infection were investigated in Pangasianodon hypophthalmus. To aim this, four isocaloric and iso-nitrogenous diets were prepared: control feed (no supplementation), Se-NPs at 0.2 mg kg−1 diet with EPA + DHA at 0.2, 0.4 and 0.6% as supplemented diets. Fish were reared under normal condition or concurrent exposure to arsenic (2.65 mg L−1), and temperature (34 °C) (As + T) stress for 105 days. The experiment was conducted with eight treatments in triplicates. Response to various stresses i.e., primary (cortisol), secondary (oxidative stress, immunity, and stress biomarkers) and tertiary stress response (growth performance, bioaccumulation and mortality due to bacterial infection) were determined. Supplementation of dietary Se-NPs at 0.2 mg kg−1 diet and EPA + DHA at 0.2 and 0.4% reduced the primary stress level. Exposure to arsenic and temperature (As + T) and fed with control diet and EPA + DHA at 0.6% aggravated the cortisol level. Anti-oxidative enzymes (Catalase, superoxide dismutase, glutathione peroxidase and glutathione-s-transferase) and immunity (Nitroblue tetrazolium, total protein, albumin, globulin, A:G ratio, total immunoglobulin and myeloperoxidase) of the fish were augmented by supplementation of Se-NPs and EPA + DHA at 0.2 and 0.4%. Neurotransmitter enzyme, HSP 70, Vitamin C were significantly enhanced (p < 0.01) with supplementation of Se-NPs at 0.2 mg kg−1 and EPA + DHA at 0.2 and 0.4%. Whereas total lipid, cholesterol, phospholipid, triglyceride and very low-density lipoprotein (VLDL) were reduced (p < 0.01) with the supplementation of Se-NPs at 0.2 mg kg−1 diet and EPA + DHA at 0.2 and 0.4%. Tertiary stress response viz. growth performance was also significantly enhanced with supplementation of Se-NPs at 0.2 mg kg−1 and EPA + DHA at 0.2 and 0.4% reared under As + T. Whereas arsenic bioaccumulation in fish tissues was significantly reduced with dietary supplementation of Se-NPs and EPA + DHA. Cumulative mortality and relative percentage survival were reduced with Se-NPs at 0.2 mg kg−1 and EPA + DHA at 0.2 and 0.4%. The investigation revealed that a novel combination of Se-NPs at 0.2 mg kg−1 and EPA + DHA at 0.4% followed by 0.2% has the potential to alleviate temperature stress, bacterial infection and arsenic pollution. Whereas diet containing Se-NPs at 0.2 mg kg−1 diet and EPA + DHA at 0.6% was noticeably enhanced the stress in P. hypophthalmus.

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“…The vitamin and mineral mixture free from selenium and riboflavin were prepared manually. Finally, the ingredient were appropriately mixed and steam cooked except vitamin and mineral mixture and Se-NPs and RF 20 (Table 1). The proximate composition of the diet was also determined as per standard methods of AOAC 36 .…”

Section: Methodsmentioning

confidence: 99%

“…Nutritional intervention could play a pivotal role in minimizing such inimical impacts on fish 8 . Riboflavin (RF) and selenium nanoparticles (Se-NPs) have been used to reduce the effects of multiple stressors (arsenic pollution and elevated temperature) and enhance growth performance and immunity of the fishes 20 . Selenium (Se) has the potential to improve anti-oxidative status and immunity of fish 21 .…”

mentioning

confidence: 99%

Mitigation potential of selenium nanoparticles and riboflavin against arsenic and elevated temperature stress in Pangasianodon hypophthalmus

Kumar

Gupta

Chandan

et al. 2020

Sci Rep

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Climate change impact has disturbed the rainfall pattern worsening the problems of water availability in the aquatic ecosystem of India and other parts of the world. Arsenic pollution, mainly through excessive use of groundwater and other anthropogenic activities, is aggravating in many parts of the world, particularly in South Asia. We evaluated the efficacy of selenium nanoparticles (Se-NPs) and riboflavin (RF) to ameliorate the adverse impacts of elevated temperature and arsenic pollution on growth, anti-oxidative status and immuno-modulation in Pangasianodon hypophthalmus. Se-NPs were synthesized using fish gill employing green synthesis method. Four diets i.e., Se-NPs (0 mg kg−1) + RF (0 mg kg−1); Se-NPs (0.5 mg kg−1) + RF (5 mg kg−1); Se-NPs (0.5 mg kg−1) + RF (10 mg kg−1); and Se-NPs (0.5 mg kg−1) + RF (15 mg kg−1) were given in triplicate in a completely randomized block design. The fish were treated in arsenic (1/10th of LC50, 2.68 mg L−1) and high temperature (34 °C). Supplementation of the Se-NPs and RF in the diets significantly (p < 0.01) enhanced growth performance (weight gain, feed efficiency ratio, protein efficiency ratio, and specific growth rate), anti-oxidative status and immunity of the fish. Nitroblue tetrazolium (NBT), total immunoglobulin, myeloperoxidase and globulin enhanced (p < 0.01) with supplementation (Se-NPs + RF) whereas, albumin and albumin globulin (A:G) ratio (p < 0.01) reduced. Stress biomarkers such as lipid peroxidation in the liver, gill and kidney, blood glucose, heat shock protein 70 in gill and liver as well as serum cortisol reduced (p < 0.01) with supplementation of Se-NPs and RF, whereas, acetylcholine esterase and vitamin C level in both brain and muscle significantly enhanced (p < 0.01) in compared to control and stressors group (As + T) fed with control diet. The fish were treated with pathogenic bacteria after 90 days of experimental trial to observe cumulative mortality and relative survival for a week. The arsenic concentration in experimental water and bioaccumulation in fish tissues was also determined, which indicated that supplementation of Se-NPs and RF significantly reduced (p < 0.01) bioaccumulation. The study concluded that a combination of Se-NPs and RF has the potential to mitigate the stresses of high temperature and As pollution in P. hypophthalmus.

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Synergistic effect of dietary selenium nanoparticles and riboflavin on the enhanced thermal efficiency of fish against multiple stress factors

Cited by 24 publications

References 59 publications

Selenium and Nano-Selenium Biofortification for Human Health: Opportunities and Challenges

Selenium and Nano-Selenium Biofortification for Human Health: Opportunities and Challenges

Mitigating multiple stresses in Pangasianodon hypophthalmus with a novel dietary mixture of selenium nanoparticles and Omega-3-fatty acid

Mitigation potential of selenium nanoparticles and riboflavin against arsenic and elevated temperature stress in Pangasianodon hypophthalmus

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