Synergistic effect of Lemon and Ginger juice for analgesic activity on Swiss albino mice

Abstract

Objective: The present study was carried out to investigate the synergestic effect of and juice for central lemon ginger and peripheral analgesic activity on experimental animals using Acetic acid induce writhing, Hot plate and Tail immersion methods. The central analgesic activity was measured by Hot plate and Tail Material and methods: immersion methods in Swiss albino mice and peripheral analgesic activity was measured by acetic acid induced writhing in Swiss albino mice. Aspirin was used as the standard drug in the dose of 100 mg/kg. The juice and lemon ginger juice was administered at 0.8 ml per animal. Phytochemical analysis showed the presence of flavonoids, alkaloids, glycosides, saponins, tannins, sterols, carbohydrates, and resins. All the doses showed significant Result: central and peripheral analgesic activity i.e (p<0.05), which is comparable to that of the control and standard drug aspirin. The test and standard drugs significantly (p<0.05) reduced the number of abdominal constriction and stretching of hind limb induce by the injection of acetic acid in a dose dependent manner. The Hot plate and Tail immersion test useful in the elucidating centrally mediated antinociceptive responses, which focused mainly on changes above the spinal cord level. All the test and standard drugs significantly (p<0.05) reduced the pain as compare to the control group. Conclusion: The results of pharmacological tests performed in the present studies suggest that the and lemon ginger juice in combination gives Synergestic effect for analgesic activity.

Evaluation of Anti Cholesterol and Antioxidant Potentiality of Aqueous Extracts of Citrus aurantifolia, Zingiber officinale and its Formulation - a Comparative In vitro Study

“…The reactive oxygen species are chemically derived from oxygen like that of hydrogen peroxide, superoxide anion and hydroxyl radicals within living organisms by metabolic pathways, while the antioxidant system is able to defend against it to maintain balance [8]. However modern lifestyle involves a number of factors that may raise the level of oxygen reactive species which has a critical part in the pathogenesis of several diseases [8,9]. Cholesterol is generally involved with fatty foods but the majority of the wax substance present in the cholesterol is produced by the body on its own.…”