1995
DOI: 10.4049/jimmunol.154.2.922
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Synergistic effect of rapamycin and cyclosporin A in the treatment of experimental autoimmune uveoretinitis.

Abstract: Immunosuppressive drugs currently available for the treatment of autoimmune diseases display a narrow therapeutic window between efficacy and toxic side effects. The use of combinations of drugs that have a synergistic effect may expand this window and reduce the risk of toxicity. We evaluated the combination effect of rapamycin (Rapa) and cyclosporin A (CsA) in an autoimmune disease model of the eye. The dose-effect relationship of Rapa with CsA was measured in vitro on the inhibition of proliferation of reti… Show more

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Cited by 51 publications
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