Synergistic effects of chemical enhancers on skin permeability: A case study of sodium lauroylsarcosinate and sorbitan monolaurate

Karande, Pankaj; Jain, Amit; Arora, Anubhav; Ho, Moon Jean; Mitragotri, Samir

doi:10.1016/j.ejps.2007.01.004

Cited by 33 publications

(23 citation statements)

References 25 publications

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“…To study this hypothesis, interactions between L-Pro2 and PG and isolated SC or SC lipids were studied by IR spectroscopy. This technique has been widely used to monitor the action of enhancers in the skin barrier [17,24,35,42,45,46,21]. It confirmed that PG changes the hydrogen-bonding network of the SC proteins, and increases the proportion of protein in the β-sheet conformation, probably by solvation of the peptide bonds.…”

Section: Discussionmentioning

confidence: 78%

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Amino acid derivatives as transdermal permeation enhancers

Janůšová¹,

Školová²,

Tükörová³

et al. 2013

Journal of Controlled Release

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Section: Discussionmentioning

confidence: 78%

“…They demonstrated that there exist classes of enhancers for which potency and irritation are not particularly well related [17]. One of the compounds which displayed apparent efficacy without noticeable irritation potential was another amino acid derivative, N-lauroylsarcosine [21,22].…”

Section: Introductionmentioning

confidence: 99%

Amino acid derivatives as transdermal permeation enhancers

Janůšová¹,

Školová²,

Tükörová³

et al. 2013

Journal of Controlled Release

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“…This method was discussed in the 60s by Kligman et al [32] . The method is well established and used for various purposes [33][34][35] and to quantify active amounts in percutaneous penetration studies [36,37] .…”

Section: Introductionmentioning

confidence: 99%

Confocal Raman Microspectroscopy for Evaluating the Stratum Corneum Removal by 3 Standard Methods

Förster

Bolzinger

Rovere

et al. 2010

Skin Pharmacol Physiol

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Background/Aims: Stratum corneum (SC) removal is needed in biopharmaceutical studies or in evaluating the barrier function. The most common technique is the tape stripping method. However, it results in neither a homogeneous nor a complete removal. Methods: The removal qualities of tape stripping, cyanoacrylate skin surface biopsy and trypsinization were estimated in vitro via histological imaging and confocal Raman microspectroscopy (CRM) and compared. In addition, the potential of the noninvasive CRM as a replacement method is discussed. Results: Comparison between the 3 methods showed, as expected, that the tape stripping method did not result in a uniform removal over the whole surface even after 28 strips. The trypsinization and cyanoacrylate skin surface biopsies allowed a complete and uniform removal of the SC after defining a standard protocol (2 cyanoacrylate strips with a polymerization time of 15 min). Conclusion: The feasibility of CRM to control SC removal was demonstrated in vitro. Tape stripping is a simple method, but it is influenced by many extrinsic factors and axial drug quantification is difficult. With trypsinization and cyanoacrylate methods, the entire SC is removed so that quantification over the whole SC is possible but not an axial drug screening.

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“…LS, LM, VE, and EggPC have been reported to be effective transdermal penetration enhancers (24)(25)(26)(27)(28)(29)(30). We prepared several cationic liposomes containing these penetration enhancers with DOTMA and CHOL.…”

Section: Discussionmentioning

confidence: 99%