Synergistic photothermal/photodynamic suppression of prostatic carcinoma by targeted biodegradable MnO₂ nanosheets

Abstract

The biodegradability and clearance of metal-based nanomaterials have been questioned worldwide, which have greatly limited their clinical translation. Herein, ultrathin manganese dioxide (MnO 2 ) nanosheets with broad near-infrared (NIR) absorption and pH-dependent degradation properties were prepared. After being modified with polyethylene glycol-cyclic arginine-glycineaspartic acid tripeptide (PEG-cRGD), the MnO 2 nanosheets were then used as photothermal agent and nanocarrier to encapsulate chlorin e6 (Ce6) for targeted photothermal (PTT) and photodynamic (PDT) of cancer. As expected, the MnO 2 -PEG-cRGD nanosheets show high Ce6 loading capacity (351 mg/g), superb photothermal conversion performance (37.2%) and excellent colloidal stability. These nanosheets also exhibit pH-dependent and NIR-induced Ce6 release. Furthermore, the MnO 2 nanosheets can be degraded by reacting with hydrogen peroxide in the acidic microenvironment, which are able to elevate the oxygen concentration in situ and thus reverses the tumor hypoxia. Thanks to these favorable properties and the cRGD-mediated tumor-targeted ability, the fabricated MnO 2 -PEG-cRGD/Ce6 nanocomposites can be effectively up taken by alpha-v beta-3 (α v β 3 ) integrin over-expressed prostatic carcinoma PC3 cells and achieve favorable therapeutic outcomes under a single 660 nm NIR laser, which is also verified by in vitro studies. The biodegradable MnO 2 -PEG-cRGD/Ce6 nanosheets developed in this work can be a promising nanoplatform for synergetic PTT/PDT cancer therapy.

Antibacterial Activity of Manganese Dioxide Nanosheets by ROS-Mediated Pathways and Destroying Membrane Integrity

“…Ultrathin MnO 2 nanosheets, an attractive novel type of 2D material, have attracted widespread attention in energy storage, biological analysis, cell imaging and drug delivery thanks to their large surface area, high near-infrared (NIR) absorbance and good biocompatibility [ 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 ]. Two-dimensional MnO 2 nanosheets exhibit unique photothermal conversion ability due to their inherently thinness, making them excellent photothermal conversion materials for highly effective photothermal therapy (PTT) anti-tumor [ 21 ].…”

Engineered bovine serum albumin-based nanoparticles with pH-sensitivity for doxorubicin delivery and controlled release

“…Cancer has become the leading killer of humans, causing 9.6 million of death and US$1.16 trillion of economic cost every year (Copur 2019;Datta et al 2019;Ferlay et al 2019). With the rapid development of nanotechnology and material engineering, some emerging therapies including photothermal therapy (PTT), photodynamic therapy (PDT), gene therapy and immunotherapy, have been developed in these years (Mellman et al 2011;Zhang et al 2017;Zeng et al 2019;Riley et al 2019;Xu et al 2020). However, the therapeutic efficacy and biosafety have to be further improved and evaluated before clinic use (Yang et al 2013;Dickmann et al 2014;Fakhoury 2016).…”

Recent Trends in Photoacoustic Imaging Techniques for 2D Nanomaterial-Based Phototherapy

“…MoS 2 -PEG/DOX nanosheets exhibited synergistic anti-cancer effects, inhibiting tumor growth in in vivo experiments. Zeng et al reported on ultrathin MnO 2 nanosheets of polyethylene glycol-cyclic arginine-glycineaspartic acid tripeptide (PEG-cRGD) and encapsulated chlorin e6 (Ce6) for PTT/PDT synergistic cancer therapy ( Figure 5 ) [ 103 ]. In that study, the nanosheets showed photothermal efficiency of 39% and could be reduced by overexpressed acidic H 2 O 2 , which could efficiently generate O 2 and further enhance the therapeutic efficiency of PDT.…”

“…Several studies have focused on the stabilization of BP for PA applications. Sun et al fabricated TiL4-coordinated BPQDs (TiL 4 @BPQDs) for PA imaging of cancer [ 103 ]. TiL 4 enhanced the stability of BPQDs in aqueous dispersions and maintained optical properties for a prolonged time compared with bare BPQDs.…”