Synergistic value of simultaneous stress dobutamine sestamibi single-photon-emission computerized tomography and echocardiography in the detection of coronary artery disease

Senior, Roxy; Sridhara, B. S.; Anagnostou, E.; Handler, Clive; Raftery, Edward B.; Lahiri, Avijit

doi:10.1016/0002-8703(94)90269-0

Cited by 68 publications

(20 citation statements)

References 20 publications

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“…17,[26][27][28] The lower specificity of SCINT in our investigation is attributable to the false positive results associated with mild coronary stenosis, left bundle-branch block, and left ventricular hypertrophy as has been reflected in previous reports. [28][29][30] It has been reported that diagnostic accuracy of SPECT analysis is lower in women than in men and is probably related to a smaller left ventricular chamber size in women.…”

Section: Discussionmentioning

confidence: 77%

Dobutamine stress echocardiography in the diagnosis of coronary artery disease in women with chest pain: Comparison with different noninvasive tests

Rollán

Román

Vilacosta

et al. 2002

Clinical Cardiology

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SummaryBackground: Diagnosis of coronary artery disease (CAD) in women remains elusive. The classical diagnostic armamentarium has been found to be very limited. Dobutamine stress echocardiography has emerged as a powerful test in assessing CAD in the general population, but most studies failed to include women.Hypothesis: The accuracy of dobutamine stress echocardiography in the diagnosis of CAD in women with chest pain is high and superior to dipyridamole echocardiography, exercise electrocardiography, and sestamibi single-photon emission tomography (MIBI-SPECT) scintigraphy.Methods: We studied 99 consecutive women with chest pain and no previous history of CAD who underwent dobutamine echocardiography and coronary angiography. We also compared these results with those of dipyridamole echocardiography in 63 patients, exercise stress testing in 83 (48 conclusive), and MIBI-SPECT scintigraphy during dobutamine infusion in 54.Results: Significant CAD was found in 42 women. Sensitivity and specificity of dobutamine stress echocardiography were 69 and 89%, respectively. Dipyridamole echocardiogra-

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Section: Discussionmentioning

confidence: 77%

Dobutamine stress echocardiography in the diagnosis of coronary artery disease in women with chest pain: Comparison with different noninvasive tests

Rollán

Román

Vilacosta

et al. 2002

Clinical Cardiology

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“…However, the accuracy of ischemia evaluation in each coronary artery territory is not sufficiently high. [24][25][26] In contrast, TTDE permits rapid and totally non-invasive assessment of coronary arteries. In particular, TTDE might be useful in patients with electrocardiographic abnormalities such as a left bundle-branch block, in those who are unable to exercise, or in those with multivessel disease, for which stress scintigraphy and echocardiography have a relatively high possibility of false-negative studies.…”

Section: Other Non-invasive Screening Tools For Cadmentioning

confidence: 99%

Role of Transthoracic Doppler-Determined Coronary Flow Reserve in Patients With Chest Pain

Kataoka

Nakatani

Tanaka

et al. 2007

Circ J

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“…Mean time from onset of infarction to reperfusion was 5±6 h (range 0. [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]. Coronary stents were implanted in all patients (MULTI-LINK in 2 cases, GFX in 1 case, and NIR in 8 cases).…”

Section: Patientsmentioning

confidence: 99%

“…17 Segments were analyzed for systolic wall thickening and endocardial wall motion using QGS, and were graded as dyskinesis (-1) or as showing akinesis (0), severe hypokinesis (1), moderate hypokinesis (2), mild hypokinesis (3), or normokinesis (4) as the wall motion score (WMS). 15,[18][19][20] Improvement of wall motion was defined as an increase of 1 point or more in WMS over the 6 months. Mismatched segments were defined as those in which the 123 I-BMIPP SPECT defect score exceeded the 18 F-FDG PET or 99m Tc-TF SPECT defect score by 1 point or more, and also the 99m Tc-TF SPECT defect score exceeded the 18 F-FDG PET defect score by 1 point or more.…”

Section: Spect and Pet Analysesmentioning

confidence: 99%

Prediction of Functional Improvement of Ischemic Myocardium With 123I-BMIPP SPECT and 99mTc-Tetrofosmin SPECT Imaging-A Study of Patients With Large Acute Myocardial Infarction and Receiving Revascularization Therapy-

Toyama

Higuchi

Kasama

et al. 2005

Circ J

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or clinicians, the functional outcome of acute myocardial infarction (AMI) is a great concern, particularly because a large AMI often causes congestive heart failure in its clinical course. Emergency percutaneous coronary intervention (PCI) is now performed in many hospitals for patients with AMI 1-4 to salvage ischemic Circulation Journal Vol.69, March 2005 myocardium. However, in the 1970s, Heyndrickx et al reported that regional contraction remained abnormal for more than 3 h after a 5-min coronary occlusion in conscious dogs, 5 which established that the contractility of viable ischemic myocardium often does not recover at once, even though circulation to the ischemic myocardium has been restored. This phenomenon is termed myocardial stunning. [6][7][8] Whether ischemic myocardium is stunned and regains its contractility is a matter of great concern. 18 Ffluorodeoxyglucose (FDG) positron-emission tomography (PET) is considered to be the most useful method of evaluating viability of the myocardium, 9-11 but it requires a cyclotron, which limits its availability. We compared the ability of a combination of 123 I-methyl pentadecanoic acid (BMIPP) and 99m Tc tetrofosmin (TF) single-photon emission tomography (SPECT), a combination of 18 F-FDG PET Background 18 F-fluorodeoxyglucose (FDG) positron-emission tomography (PET) is assumed to be the most useful method of evaluating the viability of the myocardium, but its use is limited by the need for a cyclotron. In the present study, the ability of a combination of 99m Tc-tetrofosmin (TF) and 123 I--methyliodophenyl pentadecanoic acid (BMIPP) single-photon emission computed tomography (SPECT), a combination of 18 F-FDG PET and 123 I-BMIPP SPECT, and a combination of 18 F-FDG PET and 99m Tc-TF SPECT were compared to predict functional improvement of ischemic myocardium after a large acute myocardial infarction (AMI). Methods and ResultsTen patients with large AMI were studied by 99m Tc-TF SPECT, 123 I-BMIPP SPECT and 18 F-FDG PET within 3 weeks. Six months later, 99m Tc-TF imaging was performed. All patients underwent successful revascularization, and had no restenosis. Regional tracer uptake was scored using a 4-point scale in 20 segments of the SPECT and PET images. When the defect score of 123 I-BMIPP SPECT exceeded the defect score of 99m Tc-TF SPECT or 18 F-FDG PET by 1 point or more, and when the defect score of 99m Tc-TF SPECT exceeded the defect score of 18 F-FDG PET by 1 point or more, the segment was considered to show mismatching. When the defect score was the same in 2 tracers, the segment was considered to show matching. 99m Tc-TF imaging at 3 weeks and 6 months used quantitative gated SPECT (QGS) to score wall motion using a 6-point scale (-1= dyskinesis, 0= akinesis, 1= severe hypokinesis, 2= moderate hypokinesis, 3= mild hypokinesis, and 4= normokinesis).

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Synergistic value of simultaneous stress dobutamine sestamibi single-photon-emission computerized tomography and echocardiography in the detection of coronary artery disease

Cited by 68 publications

References 20 publications

Dobutamine stress echocardiography in the diagnosis of coronary artery disease in women with chest pain: Comparison with different noninvasive tests

Dobutamine stress echocardiography in the diagnosis of coronary artery disease in women with chest pain: Comparison with different noninvasive tests

Role of Transthoracic Doppler-Determined Coronary Flow Reserve in Patients With Chest Pain

Prediction of Functional Improvement of Ischemic Myocardium With 123I-BMIPP SPECT and 99mTc-Tetrofosmin SPECT Imaging-A Study of Patients With Large Acute Myocardial Infarction and Receiving Revascularization Therapy-

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