Synergy between Pelargonium endlicherianum essential oil and conventional antibiotics against Neisseria meningitidis and Haemophilus influenzae

Dumlupınar, Berrak; Celik, Damla Damar; Karatoprak, Gökçe Şeker; Gürer, Ümran Soyoğul

doi:10.1016/j.sajb.2021.10.006

Cited by 5 publications

(6 citation statements)

References 36 publications

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“…The combinations were tested on human leukocyte cells to determine their effects. The responsible components, determined by MIC and time–kill assays [ 139 ], were phenols.…”

Section: Resultsmentioning

confidence: 99%

Exploring the Sustainable Exploitation of Bioactive Compounds in Pelargonium sp.: Beyond a Fragrant Plant

Roman,

Voaides,

Babeanu

2023

Plants

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This review article aims to present an overview regarding the volatile compounds in different scented species of Pelargonium and their biological activities, immunomodulatory activity, cytotoxic activity, high larvicidal activity and ethnopharmacological uses. Although the Pelargonium genus includes many species, we focused only on the scented ones, with the potential to be used in different domains. Pelargonium essential oil showed great properties as antioxidant activity, antibacterial activity (against K. pneumonie, S. aureus or E. coli strains) and antifungal activity (against many fungi including Candida sp.), the responsible compounds for these properties being tannins, flavones, flavonols, flavonoids, phenolic acids and coumarins. Due to the existence of bioactive constituents in the chemical composition of fresh leaves, roots, or flowers of Pelargonium sp. (such as monoterpenoid compounds–citronellol, geraniol, linalool, and flavonoids–myricetin, quercetin and kaempferol), this species is still valuable, the bio-compounds representing the base of innovative substitutes in food processing industry, nutraceuticals, or preventive human or veterinary medicine (substitute of antibiotics). Highlighting the volatile chemical composition and properties of this scented plant aims to rediscover it and to emphasize the vast spectrum of health-promoting constituents for a sustainable approach. Future research directions should point to the application of plant biotechnology with a significant role in conservation strategy and to stimulate commercial interest.

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“…The combinations were tested on human leukocyte cells to determine their effects. The responsible components, determined by MIC and time–kill assays [ 139 ], were phenols.…”

Section: Resultsmentioning

confidence: 99%

Exploring the Sustainable Exploitation of Bioactive Compounds in Pelargonium sp.: Beyond a Fragrant Plant

Roman,

Voaides,

Babeanu

2023

Plants

View full text Add to dashboard Cite

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“…Dumlupinar et al [ 20 ] showed detailed cell damage of K. pneumoniae after treatment with a combination of Pelargonium endlicherianum essential oil with gentamicin and cefepime, by using scanning electron microscopy (SEM), resulting in increased efficacy of these antibiotics. In another study [ 19 ], the same authors proved that there was a synergistic effect of ampicillin associated with Pelargonium endlicherianum essential oil on Neisseria meningitidis . The results of this study illustrated that essential oils have two effects, the first, to increase membrane-permeability activity, and the second, to show that it had phagocytic activity in human leukocyte cells.…”

Section: Discussionmentioning

confidence: 98%

“…To our knowledge, the mechanism responsible for the synergetic action resulting from the combination of antibiotics and EO major compounds remains to be defined [ 17 , 18 ]. Nevertheless, recent studies have elucidated the mechanism of action of antibiotics associated with some essential oils against resistant bacteria [ 15 , 19 ].…”

Section: Discussionmentioning

confidence: 99%

Synergistic Action of AMX Associated with 1,8-Cineole and Its Effect on the ESBL Enzymatic Resistance Mechanism

et al. 2022

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The purpose of the present study is twofold. First, it aims to evaluate the synergistic action of the ß-lactam antibiotic; AMX is associated with 1,8-cineole on six clinical isolates of ESBL-producing Escherichia coli and Klebsiella pneumoniae strains. Second, it aims to determine the effect this association has on the ESBL enzymatic resistance mechanism. The synergistic action of AMX/1,8-cineole was evaluated using partial inhibitory concentrations (PIC), determined by a microplate, a checkerboard and time–kill assays. The effect of AMX/1,8-cineole associations on the ESBL enzymatic resistance mechanism was evaluated using a new optimized enzymatic assay. This assay was based on the determination of the AMX antibacterial activity when combined with 1,8-cineole (at subinhibitory concentrations) in the presence or absence of the ß-lactamase enzyme toward a sensitive E. coli strain. The results of both checkerboard and time–kill assays showed a strong synergistic action between AMX and 1,8-cineole. The results of the enzymatic assay showed that the combination of AMX with 1,8-cineole notably influences the enzymatic resistance of the reaction by decreasing the affinity of the β-lactam antibiotic, AMX, to the β-lactamase enzyme. All obtained results suggested that the AMX/1,8-cineole association could be employed in therapy to overcome bacterial resistance to AMX while reducing the prevalence of resistance.

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“…Root excretes the protons and organic acids that result in the acidification of soil, increased metal mobility, and decreased adsorption. These Pb-tolerant bacteria also improve phytoremediation through producing plant hormones [ 34 ]. Inoculation with Pb-tolerant bacteria reduced the Pb contents in the seeds of Indian mustard because of the metal immobilization and precipitation in the root and shoot by negatively charged particles.…”

Section: Discussionmentioning

confidence: 99%

“…While this increased lead sequestration in the shoots, it decreased the lead translocation to the seeds of Indian mustard [ 35 ]. Lead-tolerant rhizobacteria improved the soil nutritive status through nitrogen fixation and nutrient solubilization, improved plant growth hormonal production, and protected the plant from metal stress through ACC-deaminase production [ 34 , 36 ].…”

Section: Discussionmentioning

confidence: 99%

Impact Assessment of Lead-Tolerant Rhizobacteria to Improve Soil Health Using Indian Mustard (Brassica juncea) as an Indicator Plant

Mushtaq,

Akhter,

Khan

et al. 2023

Plants

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Due to ongoing human activities, heavy metals are heavily accumulated in the soil. This leads to an increase in the discharge and the quick spread of heavy metal pollution in human settlements and natural habitats, having a disastrous effect on agricultural products. The current experiment was planned to evaluate the effect of lead-tolerant-plant-growth-promoting rhizobacteria (LTPGPR) on growth, yield, antioxidant activities, physiology, and lead uptake in the root, shoot, and seed of Indian mustard (Brassica juncea) in lead-amended soil. Three pre-isolated well-characterized lead-tolerant rhizobacterial strains—S10, S5, and S2—were used to inoculate seeds of Indian mustard grown at three different levels of lead (300 mg kg−1, 600 mg kg−1, 900 mg kg−1) contaminated soil. The experiment was designed following a completely randomized design (CRD) under factorial arrangements. Lead nitrate was used as a source of lead contamination. At harvesting, data regarding growth, physiology, yield per plant, antioxidant activities, malondialdehyde and proline content, and lead uptake in the root, shoot, and seed of Indian mustard were recorded. Results demonstrated that lead contamination at all levels significantly reduced the plant growth, yield, and physiological processes. Plants inoculated with lead-tolerant rhizobacteria showed a significant improvement in plant growth, yield, antioxidant activities, and physiological attributes and cause a valuable reduction in the malondialdehyde contents of Indian mustard in lead-contaminated soil. Moreover, plants inoculated with lead-tolerant rhizobacteria also showed an increment in lead uptake in the vegetative parts and a significant reduction of lead contents in the seed of Indian mustard.

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Synergy between Pelargonium endlicherianum essential oil and conventional antibiotics against Neisseria meningitidis and Haemophilus influenzae

Cited by 5 publications

References 36 publications

Exploring the Sustainable Exploitation of Bioactive Compounds in Pelargonium sp.: Beyond a Fragrant Plant

Exploring the Sustainable Exploitation of Bioactive Compounds in Pelargonium sp.: Beyond a Fragrant Plant

Synergistic Action of AMX Associated with 1,8-Cineole and Its Effect on the ESBL Enzymatic Resistance Mechanism

Impact Assessment of Lead-Tolerant Rhizobacteria to Improve Soil Health Using Indian Mustard (Brassica juncea) as an Indicator Plant

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