Synovial biopsy

Histomorphological study of synovial lesions

“…Female preponderance was seen in rheumatoid arthritis which is similar to the various other studies [2,11] . In the present study knee joint was the common joint involved by synovial lesions in 84 patients (79.8%) out of the 104 synovial biopsies and it was most commonly affected by chronic nonspecific synovitis in 51 patients (61.4%) followed by tubercular synovitis (Figure . 5) and bakers cyst in 11 patients (13.2%) each and osteoarthritis in 3 patients (3.6%) and the rest as shown in the table . Similar observations were made by Fletcher et al [10] , M.S.Sant et al [7] , M. Sankaran Kutty [8] , Vijay et al [9] that knee was the predominant joint involved and chronic nonspecific synovitis was the commonest lesion encountered.…”

“…Similar observations were seen in studies by Fletcher et al (1975) where age range was between 12 to 88 years and mean age of presentation was 47 years, in M.S. Sant et al [7] the age group was between 20 -40 years, Sankaran Kutty [8] had maximum incidence between 20 -50 years and in Vijay et al [9] also the age group was between 40 -50 years.…”

Squamous Cell Carcinoma Arising in Chronic Osteomyelitis in Foot and Ankle

“…10,21 However, it has a definite tendency to metastasize (range 11.5% to 30%). 10 Vishniavsky reported a 14.4% incidence of metastases, 18,22 and Sedlin and Fleming, in a review of the literature of 102 patients, noted that when metastases occurred, the patient died within 18 months of ablative surgery. Patients who survived three years after amputation had a good prognosis.…”

“…Marjolin first described malignant change in chronic ulcers in 1828, and Hawkins was the first to document squamous cell carcinoma arising in chronic osteomyelitis in 1835. 10,14,18,20 This rare complication has been estimated to occur in 1.6% to 23% of all patients with chronic osteomyelitis. 3,10,13,18 The lower extremity is involved in about 85% of the instances of squamous cell carcinomas arising from chronic osteomyelitis, and the tibia is the most frequent followed by the femur and the foot and ankle.…”

“…10,14,18,20 This rare complication has been estimated to occur in 1.6% to 23% of all patients with chronic osteomyelitis. 3,10,13,18 The lower extremity is involved in about 85% of the instances of squamous cell carcinomas arising from chronic osteomyelitis, and the tibia is the most frequent followed by the femur and the foot and ankle. 4,5,8,20,25,26 Male preponderance is striking.…”