SYNOVIAL FLUID AND SERUM ANTIBODIES AGAINST CHLAMYDIA IN DIFFERENT FORMS OF ARTHRITIS: INTRA-ARTICULAR IgA PRODUCTION IN CHLAMYDIA SEXUALLY ACQUIRED REACTIVE ARTHRITIS

Abstract

SUMMARYSince the presence of Chlamydia has been shown in synovial fluid (SF) from some patients with Chlamydia reactive arthritis, we investigated whether anti-Chlamydia antibodies present in the joint are derived from the circulation or are locally produced. We compared titres of IgG, IgM and IgA antibodies against Chlamydia, and against a control antigen (tetanus toxoid), by an enzyme-linked immunosorbent assay (ELISA), in paired samples of serum and SF from Chlamydia trachomatis sexually acquired reactive arthritis (CT-SARA) patients and from patients with other forms of arthritis. The ratio of serum/SF IgA anU-Chlamydia antibodies was significantly decreased in CT-SARA patients. It is concluded that, in our experimental conditions, we found evidence for intra-articular production of IgA anti-Chlamydia antibodies.

IgM Chlamydia Trachomatis Antibodies in Cases of Melasma

“…High titers of IgM antibodies to C.trachomatis have been demonstrated in only 44% of cases of perihepatitis with findings of PID (Fitz-Hugh-Curtis syndrome) by one author [13]. ELISA test of patients suspected to have C.trachomatis infection has recently been used as a diagnostic tool [14][15][16][17][18][19]. Hence we used this test to demonstrate IgM antibodies in cases of melasma.…”

Evolution to a Chronic Disease Niche Correlates with Increased Sensitivity to Tryptophan Availability for the Obligate Intracellular Bacterium Chlamydia pneumoniae

“…Respiratory infections are the most common, with seroepidemiological surveys indicating that infection is both endemic and epidemic. Asymptomatic infections are common, usually manifesting as mild upper tract infections that are self-limiting, although they may progress to more-severe upper respiratory tract infections (pharyngitis, sinusitis, and otitis) and lower respiratory tract infections (acute bronchitis, exacerbations of chronic bronchitis and asthma, and community-acquired pneumonia) (28)(29)(30)(31)(32)(33)(34)(35)(36)(37). The species was initially "discovered" in Finland in 1985, where it caused epidemics of pneumonia in military barracks (38), and, after its initial worldwide characterization (39)(40)(41)(42), was thought to have declined somewhat in prevalence.…”

Detecção do DNA de Chlamydia trachomatis em espondiloartropatias e artrite reumatóide

“…As taxas de prevalência encontradas foram 38,8% (7/18 amostras) (16) (42,45) . Entretanto, Bas et al (46) , pesquisando anticorpos IgG e IgM anticlamidiais no soro e no líquido sinovial, em uma população de 26 portadores de EI, encontraram um porcentual menor de positividade (de aproximadamente 15%), tanto para anticorpos da classe IgG quanto IgM. Não houve discrepância quanto à detecção dos anticorpos no soro e no líquido sinovial.…”

“…O valor da detecção de anticorpos anticlamidiais no diagnóstico da EI e ARe é controverso, porque esses anticorpos são freqüentes na população em geral (44,46,49) .…”