Synovial fluid levels of lactate dehydrogenase in patients with total knee arthroplasty

Messieh, Michael

doi:10.1016/s0883-5403(96)80042-8

Cited by 3 publications

(2 citation statements)

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“…Using the same cut-off as these authors, we observed better sensitivity and specificity for WBC counts in synovial fluid than for measurement of CRP and ESR. Lactate dehydrogenase, or lactate, is an indicator of cell death and lysis, and elevated levels of these substances in synovial fluid can be due to infectious disorders or to inflammatory conditions caused by particulate cement debris, metallosis, polyethylene wear, or hypersensitivity allergic reactions (Messieh 1996). These findings explain our data showing increased lactate levels in all three groups of patients and no significant differences between the groups.…”

Section: Discussionsupporting

confidence: 69%

Inflammatory response in 85 patients with loosened hip prostheses: A prospective study comparing inflammatory markers in patients with aseptic and septic prosthetic loosening

Nilsdotter-Augustinsson

Briheim

Herder

et al. 2007

Acta Orthopaedica

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Background The most common complications of prosthetic hip joints are aseptic mechanical failure and infection. Delayed low-grade infections are seen most often, and they are also most difficult to distinguish from aseptic mechanical failures.Methods We conducted a prospective study to compare inflammatory markers in patients diagnosed with aseptic or septic prosthetic loosening. The diagnostic criteria were based on the decisions of experienced orthopedic surgeons and microbiological analysis of periprosthetic tissue samples taken perioperatively.Results Coagulase-negative staphylococci were the commonest pathogens in the infected patients. Pre-or perioperative elevation of C-reactive protein and erythrocyte sedimentation rate were significantly greater in the infection group, as were white blood cell count and levels of cytokines in synovial fluid. The patterns of infiltration of inflammatory cells in periprosthetic tissue were also significantly different between the groups.Interpretation A combination of clinical judgment and multiple tissue samples constitutes a good platform for distinguishing between septic and aseptic loosening of prostheses. Moreover, the combined use of several laboratory and histopathological markers of inflammation, especially infiltration of polymorphonuclear cells, further helps the diagnosis.

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Section: Discussionsupporting

confidence: 69%

Inflammatory response in 85 patients with loosened hip prostheses: A prospective study comparing inflammatory markers in patients with aseptic and septic prosthetic loosening

Nilsdotter-Augustinsson

Briheim

Herder

et al. 2007

Acta Orthopaedica

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“…[32] noted a significant correlation between synovial lactate dehydrogenase (LDH) levels and polyethylene wear in eleven patients undergoing revision knee arthroplasty.…”

Section: Other Outcomesmentioning

confidence: 99%

Biomarkers in Arthroplasty: A Systematic Review

Mertens

Singh²

2011

TOORTHJ

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We performed a systematic review of all MEDLINE-published studies of biomarkers in arthroplasty. Thirty studies met the inclusion criteria; majority evaluated biomarkers for osteolysis, aseptic prosthetic loosening, and prosthetic infections. Four studies reported an elevated Cross-linked N-telopeptides of type I collagen (urine or serum) in patients with osteolysis or aseptic prosthetic loosening when compared to appropriate controls. Two or more studies each found elevated C-reactive protein, erythrocyte sedimentation rate, and interleukin-6 in patients with infected prosthetic joints compared to controls. Most other biomarkers were either examined by single studies or had inconsistent or insignificant associations with outcomes. We conclude that the majority of the biomarkers currently lack the evidence to be considered as biomarkers for arthroplasty outcomes. Further studies are needed.

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In vivo expression of osteogenic markers and bone mineral density at the surface of fluoride-modified titanium implants

et al. 2008

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Synovial fluid levels of lactate dehydrogenase in patients with total knee arthroplasty

Cited by 3 publications

References 3 publications

Inflammatory response in 85 patients with loosened hip prostheses: A prospective study comparing inflammatory markers in patients with aseptic and septic prosthetic loosening

Inflammatory response in 85 patients with loosened hip prostheses: A prospective study comparing inflammatory markers in patients with aseptic and septic prosthetic loosening

Biomarkers in Arthroplasty: A Systematic Review

In vivo expression of osteogenic markers and bone mineral density at the surface of fluoride-modified titanium implants

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