Synovial sarcoma of the larynx in a child: Case report and histological appearances

Abstract

Synovial sarcoma of the larynx is extremely rare having been reported only six times previously in the literature. We add another case report, which to our knowledge is the first recorded case in a child. We discuss the alternative approach of combination chemotherapy and radiotherapy which in this case led to a remission lasting about 3 years. The immunohistological and ultrastructural characteristics of the tumour are also presented.

Synovial sarcoma: A rare tumor of larynx

“…Only two cases underwent chemotherapy to whom ifosfamide was given in high doses. 3,12 In our case a chemotherapy consisting of ifosfamide and adriamycin were applied. The therapy was effective and the metastatic nodules disappeared.…”

“…The literature includes about 10 cases of synovial sarcoma of the larynx. [2][3][4]6,7,[9][10][11][12][13][14] Most cases were treated either with surgery alone or combined with radiotherapy. Only two cases were reported to whom chemotherapy was administered.…”

“…Only two cases were reported to whom chemotherapy was administered. 3,12 A laryngeal synovial sarcoma treated with surgery, radiotherapy and chemotherapy was presented and the differential diagnosis was reviewed.…”

Primary Monophasic Synovial Sarcoma Arising in the Mesentery: Case Report of an Extremely Rare Mesenteric Sarcoma Confirmed by Molecular Detection of aSYT-SSX2Fusion Transcript

“…However, it may also arise in unexpected sites, such as head and neck regions1 and even the genitourinary tract 2. Primary intra-abdominal or retroperitoneal synovial sarcoma is a rare condition.…”

SYNOVIAL SARCOMA OF THE NECK IN A CHILD: A Multidisciplinary Approach

“…In most cases it arises from the pharyngeal region rather than from other structures [5,[9][10][11][12][13][14][15][16][17][18][19].…”