Synovial Sarcomas of the Neck

Batsakis, John G.; Nishiyama, Ronald H.; Sullinger, Glen D.

doi:10.1001/archotol.1967.00760040329016

Cited by 37 publications

(15 citation statements)

References 8 publications

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“…Because SS has classically been recognized as a neoplasm arising in the juxta-articular peripheral soft tissue in adolescents or young adults (1)(2)(3)(4)(5)(6), and MPNST has been associated with peripheral nerves, especially in persons with neurofibromatosis (NF-1), clinical features have often been used as a means to discriminate between the two tumors. However, clinical features have become less diagnostically valuable with the documentation of SS inpatients of a wider age range and in a greater diversity of anatomic sites (7)(8)(9)(10)(11)(12)(13)(14). Notably, putative examples of both mono-and biphasic SS have been described within, and in association with, major nerves (15)(16)(17)(18)(19).…”

mentioning

confidence: 99%

Malignant Peripheral Nerve Sheath Tumors with t(X;18). A Pathologic and Molecular Genetic Study

et al. 2000

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Spindle cell sarcomas often present the surgical pathologist with a considerable diagnostic challenge. Malignant peripheral nerve sheath tumor, leiomyosarcoma, fibrosarcoma, and monophasic synovial sarcoma may all appear similar histologically. The application of ancillary diagnostic modalities, such as immunohistochemistry and electron microscopy, may be helpful in the differentiation of these tumors, but in cases in which these adjunctive techniques fail to demonstrate any more definitive evidence of differentiation, tumor categorization may remain difficult. Cytogenetic and molecular genetic characterization of tumors have provided the basis for the application of molecular assays as the newest components of the diagnostic armamentarium. Because the chromosomal translocation t(X;18) has been observed repeatedly in many synovial sarcomas, it has been heralded as a diagnostic hallmark of synovial sarcoma. To formally test the specificity of this translocation for the diagnosis of synovial sarcoma, RNA extracted from formalin-fixed, paraffin-embedded tissue from a variety of soft tissue and spindle cell tumors was evaluated for the presence of t(X;18) by reverse transcriptasepolymerase chain reaction. Although 85% of the synovial sarcomas studied demonstrated t(X;18), 75% of the malignant peripheral nerve sheath tumors in our cohort also demonstrated this translocation. We conclude that the translocation t(X;18) is not specific to synovial sarcoma and discuss the implications of the demonstration of t(X;18) in a majority of malignant peripheral nerve sheath tumors.KEY WORDS: Chromosomal translocation; malignant peripheral nerve sheath tumor; specificity; synovial sarcoma; t(X;18).

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confidence: 99%

Malignant Peripheral Nerve Sheath Tumors with t(X;18). A Pathologic and Molecular Genetic Study

et al. 2000

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“…The pathogenesis of synovial sarcomas arising in the head and neck region has been discussed elsewhere (Batsakis et al, 1961) and is beyond the scope of this report. It has been suggested that they may follow a more protracted and benign course than their counterpart in the periphery (Roth et al, 1975;Shmookler et al, 1982).…”

Section: Discussionmentioning

confidence: 98%

“…A primary head and neck site is extremely rare. Less than 50 cases have been reported in the English literature, and most of these occurred in the paravertebral and hypopharyngeal areas (Batsakis et al, 1961;Roth et al, 1975). Only five cases have been described in the area of the soft palate-tonsillar fossa (Lockey, 1976;Shmookler et al, 1982).…”

Section: (Received January 1983)mentioning

confidence: 99%

Calcified synovial sarcoma of the oropharynx

Genest¹,

Kim²,

Katsarkas³

et al. 1983

BJR

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“…It is also better in localized disease, i.e., less than 5 cm diameter tumors have a better prognosis. 11 Five-year survival rates vary from 29% 12 to over 50% 10 in different articles, but seem to be better for tumors of the head and neck, 13 as compared to other sites.…”

Section: Prognosismentioning

confidence: 99%