2008
DOI: 10.1111/j.1365-2516.2008.01890.x
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Synoviorthesis in haemophilia patients with inhibitors

Abstract: Recurrent bleeding into joints represents the clinical hallmark of haemophilia and, if not adequately treated, it may cause chronic synovitis and degenerative arthropathy. In haemophilia patients with inhibitors, a more severe degree of synovitis is often observed owing to the fact that treatment is more problematic in this setting. The first treatment option of recurrent haemarthroses and/or chronic synovitis is represented by synoviorthesis, both chemical and radioisotopic, with a success rate of approximate… Show more

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Cited by 18 publications
(8 citation statements)
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“…Good outcomes were found in inhibitors patients, similar to that reported by other authors [34–36]. Although the incidence of haemarthroses in patients with and without inhibitors is usually similar [35,36], the burden of orthopaedic problems is known to be more severe in the individuals with inhibitors [36]. We found a higher number of haemarthroses pre‐RS in the non‐inhibitor group (mean 21.39) than in the inhibitors (mean 16.2), independent of age or radiological status.…”
Section: Discussionsupporting
confidence: 88%
“…Good outcomes were found in inhibitors patients, similar to that reported by other authors [34–36]. Although the incidence of haemarthroses in patients with and without inhibitors is usually similar [35,36], the burden of orthopaedic problems is known to be more severe in the individuals with inhibitors [36]. We found a higher number of haemarthroses pre‐RS in the non‐inhibitor group (mean 21.39) than in the inhibitors (mean 16.2), independent of age or radiological status.…”
Section: Discussionsupporting
confidence: 88%
“…It can also be used when moderate hemarthropathy exists and surgical interventions are not yet required. RSO is an option when inhibitors against factor VIII/IX are present [77,78] or when synovitis persists over 6 months despite intensified factor therapy [58,78]. Before the onset of hemarthropathy, RSO should be used as a first-line treatment in chronic synovitis [58,[78][79][80].…”
Section: Efficacy Of Rso In Hemophiliamentioning
confidence: 99%
“…RSO is an option when inhibitors against factor VIII/IX are present [77,78] or when synovitis persists over 6 months despite intensified factor therapy [58,78]. Before the onset of hemarthropathy, RSO should be used as a first-line treatment in chronic synovitis [58,[78][79][80]. Finally, if the synovitis persists or relapses after the first RSO, it is proposed that the procedure can be repeated up to three times.…”
Section: Efficacy Of Rso In Hemophiliamentioning
confidence: 99%
See 1 more Smart Citation
“…In general, medical synovectomy is considered first. The term synoviorthesis (medical synovectomy) is commonly used to describe the intra-articular injection of a substance producing fibrosis of the synovium and subsynovial plexus [ 13 , 14 ]. There are two basic types of medical synovectomy: chemical or radiological.…”
Section: Introductionmentioning
confidence: 99%